2-oxabicyclo[2.1.1]hexane

2-Oxabicyclo[2.1.1]hexane as a Replacement for ortho- and meta-Disubstituted Benzenes: From Geometric Matching to Functional Validation

2-Oxabicyclo[2.1.1]hexane (2-oxa-BCH) is a rigid, sp³-rich, oxygen-containing bicyclic scaffold. Based on crystallographic structures, a 2020 study proposed that 1,4-disubstituted 2-oxa-BCH could mimic meta-disubstituted benzene, although the corresponding biological activity had not yet been ...