Protein kinases and phosphatases jointly regulate the phosphorylation states of proteins, thereby affecting cellular signaling, metabolism, proliferation, and stress responses. Phosphorylation or dephosphorylation does not directly equate to protein activation or inactivation, and its effect ...
In recent years, protein tyrosine phosphatase SHP2 has become a highly regarded research target in the field of oncology in mediating the RAS-driven MAPK signaling pathway. Its treatment methods are not limited to single drug use, but also can work together with KRAS inhibitors, showing good ...