PI3K-Akt-mTORC Signaling
mTOR is a serine/threonine kinase and the catalytic subunit of the mTORC1 and mTORC2 complexes. mTORC1 is involved in energy homeostasis signaling. Akt phosphorylation regulates TSC2, inhibiting the activity of the TSC1/TSC2 heterodimer, relieving its suppression of mTORC1 and sustaining activation.
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