Rigid bicyclic amines

Minute-Scale Construction of Fluorinated Nitrogen-Bridged Bicycles: Pd(II)/Pd(IV) Cascade Chemistry and a Pd(IV) “Dyotropic (Paired-Migration)” Rearrangement Driving Strain-Release Ring Expansion

Nitrogen-bridged frameworks (rigid bicyclic amines) are widely used in medicinal chemistry to increase three-dimensionality and conformational restriction, thereby influencing target binding, basicity, and metabolic stability. 2-Azabicyclo[3.2.1]octane is a representative example: it has a ...