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Drug synthesis

用于检测、定量和定位抗原与抗体的技术——ELISA、免疫印迹、免疫组化与流式细胞术。以下是我们知识库中标注该主题的实验方案、常见问题与技术文章。

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Construction and Transformation of Aziridines in Drug Synthesis: Ring Strain, N-Substituent Control, Selective Ring Opening, and Scaffold Expansion

Amino groups, amino alcohols, vicinal diamines, and saturated nitrogen-containing heterocycles are widely found in drug molecules and their synthetic intermediates. The synthesis of these structures requires not only the introduction of nitrogen atoms, but also control over the position of ...

更新于 2026年8月阅读12分钟

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2-Methylpyridine–Borane (2-Picoline·BH₃) Reductive Amination Guide: Process Drivers for Replacing NaBH₃CN, the Practical Operating Window, and Scale-Up/Quench Close-Out Essentials (Including Product Tables 1–3)

Converting aldehydes/ketones into amines is one of the most common C–N bond-forming approaches in pharmaceutical synthesis, monomer modification for materials, and fine chemical manufacturing. Reductive amination is popular largely because it can often be done “one-pot”: the carbonyl and amine ...

更新于 2026年2月阅读12分钟

Construction and Transformation of Aziridines in Drug Synthesis: Ring Strain, N-Substituent Control, Selective Ring Opening, and Scaffold Expansion

2-Methylpyridine–Borane (2-Picoline·BH₃) Reductive Amination Guide: Process Drivers for Replacing NaBH₃CN, the Practical Operating Window, and Scale-Up/Quench Close-Out Essentials (Including Product Tables 1–3)

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