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Lysosome

以下是知识库中与该主题相关的实验方案、常见问题、指南与技术文章。

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LYSET: The Lysosomal Enzyme Trafficking Hub Behind Cancer Cell Survival

LYSET is an important Golgi membrane protein that maintains the correct trafficking of lysosomal enzymes by regulating GNPT and the mannose-6-phosphate pathway. Under nutrient-limited conditions, some cancer cells depend on lysosomal degradation of extracellular proteins to obtain amino acids, ...

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Molecular Mechanisms, Selective Degradation, and Disease Regulation of Autophagy

Autophagy is an essential lysosome-dependent quality-control process through which cells degrade and recycle intracellular material. Based on how substrates enter degradative compartments, autophagy is primarily classified into macroautophagy, microautophagy, and chaperone-mediated autophagy. ...

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The Role of Lysosomes in Metabolic and Autoimmune Diseases

Lysosomes are core organelles for cellular catabolism and quality control. They are responsible for degrading materials derived from intracellular autophagy, extracellular endocytosis, phagocytosis, and macropinocytosis. In addition to degradation, lysosomes participate in nutrient sensing, mTOR ...

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