Haptoglobin (Hp): A Key Carrier in the Free Hemoglobin Clearance–Detoxification Axis, with Assays and Applications
Haptoglobin (Hp) is an α2-globulin glycoprotein primarily synthesized by hepatocytes and secreted into plasma. Hp binds free hemoglobin (Hb) released during intravascular hemolysis with high affinity, forming Hp–Hb complexes that are cleared via receptor-mediated pathways (notably CD163). This ...
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