Interferon-stimulated genes (ISGs) constitute the core effector layer for establishing the cellular antiviral state. After viral RNA is recognized by pattern recognition receptors such as RIG-I and MDA5, type I/type III interferon production can be induced through MAVS, TBK1, IRF3/IRF7, and ...
Interleukin-29 (IL-29) is a key member of the type III interferon family and is also commonly referred to as interferon lambda 1 (IFN-λ1). IL-29 carries both an “IL-series” designation and a clear interferon-like functional identity.