One pot method for peptide chain elongation

Reassessing Trimethylaluminum: Method Design and Experimental Value of One-Pot Peptide Elongation from Unprotected Amino Acids

Trimethylaluminum (AlMe3)-mediated one-pot peptide elongation refers to a peptide synthesis strategy in which unprotected amino acids first react with trimethylaluminum to form an aluminum-containing five-membered ring intermediate. This five-membered ring then reacts with an amino acid ester at ...