Experimental Judgment for Differential Deprotection of Double Boc and Related N-Boc Systems: Substrate Type, Site-Response Differences, and Initial Condition Selection
The key to selective mono-deprotection of double Boc systems lies in whether a sufficient difference in reaction rate can be established among the doubly protected substrate, the mono-deprotected intermediate, and the fully deprotected product. In conventional Boc deprotection, the usual ...
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