Oligonucleotide chemical synthesis

Coupling Activators, Nucleoside Building Blocks, and Modification Design in Oligonucleotide Chemical Synthesis: Their Effects on Synthetic Efficiency, Purity, and Product Properties

The task of oligonucleotide chemical synthesis is not merely to link monomers together in sequence. It also involves increasing the proportion of full-length product, reducing deletion sequences and other impurities, preserving structural integrity after post-synthetic processing, and ensuring ...