受体酪氨酸激酶异常信号在肿瘤发生、精准分型与靶向治疗中的作用
受体酪氨酸激酶（receptor tyrosine kinase，RTK）通过酪氨酸磷酸化调控细胞增殖、存活、迁移和分化。RTK突变、扩增、融合或异常表达可持续激活MAPK、PI3K/AKT、STAT和PLC等信号通路，推动肿瘤发生并影响分子分型、靶向治疗及耐药。
主题
ALK
用于检测、定量和定位抗原与抗体的技术——ELISA、免疫印迹、免疫组化与流式细胞术。以下是我们知识库中标注该主题的实验方案、常见问题与技术文章。
6 项资源 · 实验方案、常见问题与文章
Role of Aberrant Receptor Tyrosine Kinase Signaling in Tumorigenesis, Precision Classification, and Targeted Therapy
Receptor tyrosine kinases (RTKs) regulate cell proliferation, survival, migration, and differentiation through tyrosine phosphorylation. RTK mutations, amplifications, fusions, or abnormal expression can continuously activate MAPK, PI3K/AKT, STAT, PLC, and other signaling pathways, thereby ...
非小细胞肺癌的分子分型、驱动靶点与耐药机制
非小细胞肺癌具有显著的组织学和分子异质性。EGFR、ALK、ROS1、KRAS、BRAF、RET、MET和HER2等异常可持续激活肿瘤细胞增殖与存活信号，并形成具有不同生物学特征和药物敏感性的分子亚型。
Molecular Classification, Oncogenic Drivers, and Resistance Mechanisms of Non-Small Cell Lung Cancer
Non-small cell lung cancer exhibits substantial histological and molecular heterogeneity. Alterations involving EGFR, ALK, ROS1, KRAS, BRAF, RET, MET, HER2, and other oncogenic drivers can continuously activate tumor-cell proliferation and survival signaling and generate molecular subtypes with ...
BMP Signaling Pathway: Molecular Components, Signal Transduction Mechanisms, and Biological Functions
The BMP pathway is one of the most representative developmental and homeostatic regulatory pathways within the TGF-β superfamily. It participates in embryonic patterning, bone and cartilage formation, vascular and neural development, stem cell fate determination, and tissue repair.
BMP通路的分子组成、信号转导机制与生物学功能
BMP通路是TGF-β超家族中最具代表性的发育与稳态调控通路之一，参与胚胎模式建立、骨与软骨形成、血管与神经发育、干细胞命运决定以及组织修复等过程。
相关主题
常与免疫学实验一起研究的技术。
危险品化学品经营许可证（带存储）