肿瘤微环境中ECM动态重塑如何调控 肿瘤免疫应答？
肿瘤微环境中的细胞外基质（extracellular ...
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TGF-β
用于检测、定量和定位抗原与抗体的技术——ELISA、免疫印迹、免疫组化与流式细胞术。以下是我们知识库中标注该主题的实验方案、常见问题与技术文章。
7 项资源 · 实验方案、常见问题与文章
How Does Dynamic ECM Remodeling in the Tumor Microenvironment Regulate Tumor Immune Responses?
The extracellular matrix (ECM) in the tumor microenvironment not only supports tissue structure, but also continuously regulates immune cell infiltration, migration, activation, and effector functions through matrix deposition, crosslinking, degradation, and spatial reorganization. ECM ...
TGF-β信号转导通路的结构基础、转导分支与研究应用
TGF-β信号转导通路是调控细胞命运、组织稳态与病理重塑的重要分子网络。该通路以配体活化、受体复合体组装和Smad依赖性转录调控为核心，同时与ERK、JNK、p38等非Smad分支交叉，广泛参与纤维化、上皮-间质转化、免疫抑制和肿瘤进展等过程。 ...
Structural Basis, Transduction Branches, and Research Applications of the TGF-β Signaling Pathway
The TGF-β signaling pathway is an important molecular network that regulates cell fate, tissue homeostasis, and pathological remodeling. This pathway is centered on ligand activation, receptor complex assembly, and Smad-dependent transcriptional regulation, while also intersecting with non-Smad ...
Transforming Growth Factor-β: Family Lineages, Receptor Signaling Networks, and Key Technical Points for Applications
Transforming growth factor-β (TGF-β) is a core member of a multifunctional cytokine family and exerts systemic influence in embryonic development, immune homeostasis, tissue repair, extracellular matrix (ECM) remodeling, and regulation of the tumor microenvironment. TGF-β initiates signaling ...
转化生长因子-β：家族谱系、受体信号网络与应用技术要点
转化生长因子-β（Transforming Growth Factor-β，TGF-β）是多功能细胞因子家族的核心成员，在胚胎发育、免疫稳态、组织修复、细胞外基质重塑与肿瘤微环境调控中具有系统性影响。TGF-β通过I型与II型丝氨酸/苏氨酸激酶受体复合体启动信号转导，经典通路以SMAD2/3- ...
Regulation of TGF-beta activity by BMP-1
The TGF-β family (Transforming growth factor-beta family) includes members of TGF-β1, TGF-β2, TGF-β3, BMP (Bone morphogenetic protein), Activin, and Nodal, which play important roles in a variety of biological processes including cell proliferation, differentiation, apoptosis, extracellular ...
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