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ActRIIA and ActRIIB are important receptors for TGF-β superfamily ligands such as Myostatin/GDF8 and Activin A. Through SMAD2/3 signaling, they restrict skeletal muscle growth and participate in adipose tissue metabolism. Blocking ActRIIA/ActRIIB can increase or preserve Lean Mass while ...
ActRIIA和ActRIIB是Myostatin/GDF8、Activin A等TGF-β超家族配体的重要受体，通过SMAD2/3信号限制骨骼肌生长并参与脂肪组织代谢。阻断ActRIIA/ActRIIB可增加或保护瘦体重并促进脂肪量下降，使其成为减重过程中改善体成分的重要干预方向。
The GDF (growth differentiation factor) family is an important branch of the TGF-β superfamily. Its members are widely involved in embryonic development, osteochondral formation, skeletal muscle homeostasis, reproductive regulation, metabolic stress, tissue injury repair, and remodeling of the ...
GDF（growth differentiation factor，生长分化因子）家族是TGF-β超家族中的重要分支，成员广泛参与胚胎发育、骨软骨形成、骨骼肌稳态、生殖调控、代谢应激、组织损伤修复及肿瘤微环境重塑等过程。
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