GRK2 Inhibitor 2 is an orally active and selective G protein-coupled receptor kinase 2 ( GRK ) inhibitor with an IC 50 of 19 nM. GRK2 Inhibitor 2 also inhibits Aurora-A with an IC 50 of 137 nM. GRK2 Inhibitor 2 can be used in the study of congestive heart failure (HF).