Guangxitoxin 1E TFA 是一种肽毒素,是电压门控钾通道 KV2.1 和 KV2.2 的选择性抑制剂,IC50 为 1-3 nM。Guangxitoxin 1E TFA 可增强葡萄糖刺激的细胞内钙离子振荡,并以葡萄糖依赖的方式增加胰岛素分泌
Guangxitoxin 1E TFA, a peptide toxin, is a selective inhibitor of voltage-gated potassium channels KV2.1 and KV2.2 with an IC50 of 1-3 nM. Guangxitoxin 1E TFA can enhance glucose-stimulated intracellular calcium ion oscillation and increase insulin secretion in a glucose-dependent manner