计算溶液所需的质量、体积或浓度。
概述
GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM.
In Vitro
GPX4-IN-3 (26a) exhibits IC 50 values of 0.78 μM, 6.9 μM, 0.15 μM and 4.73 μM in 4T1, MCF-7, HT1080 and HT1080 (with Fer-1) cells, respectively. ?\nGPX4-IN-3 (26a) exhibits outstanding GPX4 inhibitory activity with a percent inhibition up to 71.7% at 1.0 μM compared to 45.9% of RSL-3. ?\nGPX4-IN-3 (26a) could significantly induce lipid peroxide (LPO) increase and effectively induce ferroptosis with satisfactory selectivity. ?\nGPX4-IN-3 (26a) is more likely to induce ferroptosis through the accumulation of intracellular peroxides via inhibiting GPX4 activity. ?\nGPX4-IN-3 (26a) significantly increased the level of ROS in 4T1 cells, which could also be reversed by Ferrostatin-1 (fer-1). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
GPX4-IN-3 (26a) exertes antitumor activity and good biological safety in vivo . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mouse 4T1 xenograft model . Dosage: 15 and 30 mg/kg. Administration: Intravenous injection, every two days for a total of five times. Result: Significantly suppress tumor growth with a tumor growth inhibition (TGI) value of 33.2 and 55.1% at 15 and 30 mg/kg, respectively.
规格
规格或纯度
10mM in DMSO
英文名称
GPX4-IN-3
生化机理
GPX4-IN-3 (26a) 是一种强效谷胱甘肽过氧化物酶 4 (GPX4) 抑制剂，是一种选择性铁变态反应诱导剂。GPX4-IN-3 (26a) 对 1 μM 的 GPX4 有 71.7% 的抑制作用。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
分子类型
小分子
分子量
530.04
高级数据
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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技术文档和文章
溶液计算器
常见问题
本产品应如何储存？
请于?80 °C条件下保存。需超低温保存以维持规定的有效期。
本产品如何运输？
本产品采用干冰配冷袋冷冻运输。收货后请立即拆包，并按上述储存条件保存；处理干冰时请戴隔热手套并保持通风。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 2761004-85-5，分子式为 C29H24ClN3O3S，分子量为 530.04 g/mol。
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产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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