计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥95% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
HAMI 3379 is a potent and selective CysLT 2 receptor antagonist. HAMI 3379 has a protective effect on acute and subacute ischemic brain injury, and attenuates microglia-related inflammation
In Vitro
In a CysLT 2 receptor reporter cell line, HAMI3379 antagonizes leukotriene D 4 - (LTD 4 -) and leukotriene C 4 - (LTC 4 -) induced intracellular calcium mobilization with IC 50 values of 3.8 nM and 4.4 nM respectively. HAMI3379 exhibits very low potency on a recombinant CysLT 1 receptor cell line (IC 50 >10000 nM). HAMI3379 does not exhibit any agonistic activity on both CysLT receptor cell lines. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
HAMI 3379 (0.025-0.4 mg/kg; ip) with 0.1-0.4 mg/kg significantly reduces the infarct volume and percentage increase in the ischemic/contralateral hemispheric ratio. HAMI3379 (0.1 mg/kg; ip) administered at 0 and 1 h after reperfusion reduces infarct volume, attenuated brain edema, reduced neurological score, and increased holdingangle. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats (250-300 g) after MCAODosage: 0.025, 0.05, 0.1, 0.2, 0.4 mg/kg Administration: IP Result: Significantly reduced the infarct volume and percentage increase inthe ischemic/contralateral hemispheric ratio (an index ofbrain edema) with 0.1-0.4 mg/kg. Significantly reduced the neurological deficit score.
Form:Solid
IC50& Target:CysLT 2
规格
别名
哈密 3379
规格或纯度
≥95%
英文名称
HAMI 3379
生化机理
HAMI 3379 是一种强效的选择性 CysLT 2 受体拮抗剂。HAMI 3379 对急性和亚急性缺血性脑损伤具有保护作用，并能减轻与小胶质细胞相关的炎症。
储存条件
-20°C储存
运输条件
超低温运输
作用类型
拮抗剂
纯度
≥95%
名称和识别符
分子类型
小分子
分子量
595.72
技术文档
高级数据
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