概述规格名称和识别符技术文档高级数据关联靶点（人）质检证书（CoA,COO,BSE/TSE 和分析图谱) 化学和物理性质安全和危险性（GHS）此产品的引用文献技术文档和文章引用文献溶液计算器

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为什么选择此级别

Moligand™ 级，适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

-80℃储存。特低温运输。请查阅批次 COA 获取详细规格。

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质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 28 篇同行评审文献引用。

概述

对光敏感，易吸潮可溶性鸟苷酸环化酶（guanylyl cyclase）激活剂。具有抗肿瘤活性

Information

Isoliquiritigenin Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.
In vitro

Isoliquiritigenin may be effective in preventing diabetic complications through inhibiting rat lens aldose reductase with an IC50 of 320 nM and sorbitol accumulation in human red blood cells with an IC50 of 2.0 μM. Isoliquiritigenin may also serve as a skin-lightening agent by inhibiting mono- and diphenolase tyrosinase activities with an IC50 of 8.1 μM. Isoliquiritigenin induces cell cycle arrest and cell growth inhibition in DU145 and LNCaP prostate cancer cell lines. Isoliquiritigenin induces apoptosis of human gastric cancer MGC-803 cells through increasing the intracellular free calcium concentration and decreasing the mitochondrial transmembrane potential (Deltapsi(m)).

In vivo

LD50: Mice >6g/kg (i.g.)
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

规格

英文别名

(E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one

规格或纯度

Moligand™, 10mM in DMSO

英文名称

Isoliquiritigenin

生化机理

从甘草根中提取的抗肿瘤黄酮类化合物 Isoliquiritigenin 可抑制醛糖还原酶，其 IC50 值为 320 nM。

储存条件

-80℃储存

运输条件

特低温运输

作用类型

抑制剂

名称和识别符

EC号

677-489-8

分子类型

小分子

Isomeric SMILES

C1=CC(=CC=C1/C=C/C(=O)C2=C(C=C(C=C2)O)O)O

分子量

256.25

Reaxy-Rn

1914295

Reaxys-RN link address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1914295&ln=

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

下载 SDS →

✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

查询 COA →

📊 产品数据表

产品规格和应用的快速参考摘要。

查看数据表 →

🔬 规格说明书

该级别的完整质量属性和验收标准。

查看规格说明 →

高级数据

关联靶点（人）

HSD17B2 Tchem 雌二醇 17-β-脱氢酶 2(Estradiol 17-beta-dehydrogenase 2) (1 活性数据)

点击查看靶蛋白信息： HSD17B2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

AKR1B1 Tclin 醛糖还原酶(Aldose reductase) (1 活性数据)

点击查看靶蛋白信息： AKR1B1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

化学和物理性质

熔点

198 °C

安全和危险性（GHS）

象形图

GHS07

信号词

Warning

危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激

预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P302+P352: 如皮肤沾染：用水充分清洗。

P321: 特殊处理（请参阅此标签上的...）。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P264: 处理后要彻底洗手。

P271: 仅在室外或通风良好的地方使用。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P403+P233: 存放在通风良好的地方。保持容器密闭。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。

P319: 如果你感到不适，请寻求医疗帮助。

WGK Germany

RTECS

FL7080000

个人防护装备

Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

技术文档和文章

组蛋白去乙酰化酶抑制剂

目录：技术文章

探索主题:

HDAC抑制剂

Histone Deacetylase Inhibitors

目录：技术文章

探索主题:

HDAC inhibitors

VEGFR 抑制剂

目录：技术文章

探索主题:

抑制剂肿瘤

VEGFR Inhibitors

目录：技术文章

探索主题:

Inhibitors Tumors

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站? 引用文献检索

引用文献

1. Liangwan Wei, Zhe Wang, Yindi Chu, Kun Cai, Wei Li, Piying Huang, Youcai Qin, Dailin Liu, Xiaocui Zhuang, Mingquan Guo, Xinbo Song, Enguo Fan. (2023) Licochalcone A inhibits the assembly function of β-barrel assembly machinery in Escherichia coli. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, [PMID:37245294] [10.1016/j.bbrc.2023.05.083]
2. Yufang Su, Lei Fang, Kaili Zhong, Ting Wang, Mingjie Bao, Ting Zhou, Yuan Zhu. (2023) Isoliquiritigenin induces oxidative stress and immune response in zebrafish embryos. ENVIRONMENTAL TOXICOLOGY, 38 (3): (654-665). [PMID:36617718] [10.1002/tox.23715]
3. Jianman Wang, Hongjin Chen, Tao Guo, Ping Yue, Tianbao Qian, Xiangyu Zeng, Yali Luo, Jiangmin Li, Lijing Teng, Qingyu Liu, Liang Hong, Zijiang Yu, Zuquan Hu. (2022) Isoliquiritigenin Nanoemulsion Preparation by Combined Sonication and Phase-Inversion Composition Method: In Vitro Anticancer Activities. Bioengineering-Basel, 9 (8): (382). [PMID:36004907] [10.3390/bioengineering9080382]
4. Xiangrong Li, Hongyi Liu, Zhenhua Yang, Hanxiao Duan, Ziyang Wang, Zeqing Cheng, Zhizhi Song, Xinzhe Wu. (2021) Study on the interaction of hyaluronidase with certain flavonoids. JOURNAL OF MOLECULAR STRUCTURE, [10.1016/j.molstruc.2021.130686]
5. Li-Juan Wang, Lin He, Lu Hao, Hong-Lei Guo, Xiang-Peng Zeng, Ya-Wei Bi, Guo-Tao Lu, Zhao-Shen Li, Liang-Hao Hu. (2020) Isoliquiritigenin ameliorates caerulein-induced chronic pancreatitis by inhibiting the activation of PSCs and pancreatic infiltration of macrophages. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 24 (17): (9667-9681). [PMID:32678498] [10.1111/jcmm.15498]
6. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu. (2019) Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies. Foods, 8 (9): (355). [PMID:31438605] [10.3390/foods8090355]
7. Zhang Man, Wu Yan-Qing, Xie Ling, Wu Jiang, Xu Ke, Xiao Jian, Chen Da-Qing. (2018) Isoliquiritigenin Protects Against Pancreatic Injury and Intestinal Dysfunction After Severe Acute Pancreatitis via Nrf2 Signaling. Frontiers in Pharmacology, [PMID:30174606] [10.3389/fphar.2018.00936]
8. Jie-hua Shi, Jing Wang, Ying-yao Zhu, Jun Chen. (2013) Characterization of interaction between isoliquiritigenin and bovine serum albumin: Spectroscopic and molecular docking methods. JOURNAL OF LUMINESCENCE, [10.1016/j.jlumin.2013.08.042]
9. Sisi Ke, Ningrui Wang, Xingyu Chen, Jiangwei Tian, Jiwei Li, Boyang Yu. (2025) A Label-Free Colorimetric Aptasensor for Flavokavain B Detection. SENSORS, 25 (2): (569). [PMID:39860936] [10.3390/s25020569]
10. Zhang Xiuying, Chen Qilei, Zhao Jia, Zhao Wei, Fan Ni, Wang Yu, Chen Hubiao, Rong Jianhui. (2023) A four-compound remedy AGILe protected H9c2 cardiomyocytes against oxygen glucose deprivation via targeting the TNF-α/NF-κB pathway: Implications for the therapy of myocardial infarction. Frontiers in Pharmacology, [PMID:36713834] [10.3389/fphar.2023.1050970]
11. Tian-Xiu Qiu, Lei Liu, Xu Zhang, Yang Hu, Jiong Chen. (2024) Antiviral activity of isoliquiritigenin against SVCV in aquaculture: A dual approach of immune modulation and viral inhibition. AQUACULTURE, [10.1016/j.aquaculture.2024.741863]
12. Deshan Yao, Liuxiang Bao, Sichuan Wang, Meng Tan, Yuanyuan Xu, Tianxu Wu, Zhengang Zhang, Kaizheng Gong. (2024) Isoliquiritigenin alleviates myocardial ischemia-reperfusion injury by regulating the Nrf2/HO-1/SLC7A11/GPX4 axis in mice. FREE RADICAL BIOLOGY AND MEDICINE, [PMID:38734270] [10.1016/j.freeradbiomed.2024.05.012]
13. Hu Deliang, Yang Yuqing, Fang Lei, Fan Shijie, Lin Ling, Luo Puying, Xiong Yuanhuan, Su Yufang. (2024) Isoliquiritigenin induced hepatotoxicity and endoplasmic reticulum stress in zebrafish embryos. Scientific Reports, 14 (1): (1-12). [PMID:39548255] [10.1038/s41598-024-79016-8]
14. Shuaishuai Chen, Weina Xue, Zhongxiu Wu, Dingyan Lu, Lin Zheng, Meng Zhou, Yongjun Li, Yonglin Wang, Ting Liu. (2025) Quercetin, a Compound of the Total Flavonoids of Periploca forrestii Schltr., Ameliorates Rheumatoid Arthritis by Targeting TNF-α. Journal of Inflammation Research, [PMID:40046683] [10.2147/JIR.S497166]
15. Rui Yang, Kan Zhang. (2025) Synthesis of isoliquiritigenin-based bio-benzoxazine and its role of latent curing agent for achieving high-performance epoxy thermosetting systems. Materials Today Communications, [10.1016/j.mtcomm.2025.112374]
16. Cang Li, Yu Huang, Yuchen Liu, Zhipeng Li, Yao Deng, Hao Ren, Donghao Zhao, Lu Han, Jian Sun. (2025) Self-assembly of Zein-based nanoparticles for oral isoliquiritigenin delivery against Salmonella infections. Innovative Food Science & Emerging Technologies, [10.1016/j.ifset.2025.104127]
17. Xuewa Jiang, Shaoyan Yi, Pingping Shen, Richa Raj, Jian Zhang, Haixia Ge. (2025) Insights on the synergistic effects of glycyrrhetinic acid and isoliquiritigenin on HMGB1-induced inflammation by multi-spectroscopic and molecular docking studies. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:40714661] [10.1016/j.saa.2025.126726]
18. De-Jian Chen, Cheng-Jun Liu, Zi-Hao Chen, Jin-Jin Li, Wei Shi, Qing-Min Zhang, Xia Yang, Jian-Xin Chen, Feng-Xiang Zhang. (2024) Chemical profiling of Zhi-Ke-Bao pills and its potential mechanism against cough by ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry and network pharmacology. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, [PMID:38815520] [10.1016/j.jpba.2024.116257]
19. Jue Bai, Si-Yuan Yang, Shao-Mei Yu, Ying Cao, Chang-Han Ma, Xuan-Yi Hu, Xiong Chen, Ying-Nan Song, Hong-Jin Chen. (2025) IGFBP5 mediates the therapeutic effect of isoliquiritigenin in myocardial ischemia-reperfusion injury via AKT/GLUT4 regulated insulin resistance. Frontiers in Pharmacology, [PMID:40365313] [10.3389/fphar.2025.1544869]
20. Lin Xie, Kan Zhang. (2025) Achieving very high performance polybenzoxazines from natural renewable isoliquiritigenin: design, preparation and property investigation. Polymer Chemistry, [10.1039/D5PY00311C]
21. Dunsheng Liang, Xiao-Fan Shen, Ting-Ting Li, Yao Deng, Hong-Liang Xiao, Zhi-Peng Li, Shuan-Cheng Bai, Xiao-Yu Ma, Xiao-ping Liao, Dong-Hao Zhao, Hao Ren, Chaoqun Zhang, Jian Sun, Lu Han. (2025) A bionic yeast for the colon-targeted delivery of curcumin in the treatment of inflammatory bowel disease. CHEMICAL ENGINEERING JOURNAL, [10.1016/j.cej.2025.164121]
22. Li Mengyun, Zhang Xiaobing, Lu Jiafeng, Xiang Junjie, Wu Jie, Zheng Matao, Yang Siwei, He Lingyan, Shao Xian. (2025) Isoliquiritigenin ameliorates Parkinson’s disease via gut microbiota remodeling: potential mediating role of Parabacteroides distasonis. Journal of Translational Medicine, 23 (1): (1363). [PMID:41316345] [10.1186/s12967-025-07435-w]
23. Shupeng Zhao, Haigang Chang, Pengju Ma, Guojun Gao, Cailing Jin, Xinli Zhao, Wenke Zhou, Baozhe Jin. (2015) Inhibitory effect of DNA topoisomerase inhibitor isoliquiritigenin on the growth of glioma cells. International Journal of Clinical and Experimental Pathology, [PMID:26722447] [PMID:26722447]
24. Weiyu Wu, Ren Zhang, Geer Chen, Ziyu Chen, Zicong Lin, Yin Chen, Jiaqi Li, Weilin Liao, Junyi Wang, Xiaoxuan Wang, Junhao Huang, Lijuan Ma, Haijie Yu. (2025) Sappanchalcone Suppresses NSCLC by Oxidative Stress-Driven DNA Damage and ER Stress Activation through PIEZO1 Modulation. iScience, [PMID:41399507] [10.1016/j.isci.2025.114057]
25. Yi-Min Ren, Yu Chen, Chang-Mao Jiang, Xiong Chen, Hong-Jin Qin, Zhu Wei, Xue Rao, Yu-Chen Wang, Ning-Ze Jiang, Jin-Yuan Luo-Qian, Ying-Nan Song, Xiao-Hua Zou, Jiang Zheng, Hong-Jin Chen. (2025) Isoliquiritigenin inhibited complete Freund's adjuvant-induced chronic inflammatory pain via the CCL7/CCR2/ERK pathway in dorsal root ganglia neurons of mice. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:41418643] [10.1016/j.intimp.2025.116059]
26. Hui Yu, Nan Wang, Changjiang Sun, Bingfeng Leng, Liping Sun, Xuming Deng, Lei Xu, Zihao Teng, Jianfeng Wang, Lin Wang. (2026) Targeting fimbriae adhesin of porcine enterotoxigenic Escherichia coli by isoliquiritigenin. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, [PMID:41604729] [10.1016/j.ijmm.2026.151704]
27. Luhang Dai, Guo Cheng, Tingting Cui, Sitong He, Ran Wang, Jingqi Kang, Pei Li, Xin Zhang, Xiaoli Ding, Xiaochang Xue, Luting Yang, Yaling Zhang, Yaping Yan. (2026) Activation status of astrocytes drives the MS/NMOSD therapeutic paradox: Insights from IFNAR1 signaling. Cell Reports, 45 (2): [PMID:41632569] [10.1016/j.celrep.2025.116913]
28. Jingwen Li, Hossain M. Zabed, Yufei Zhang, Junhua Yun, Yuehui Tian, Guoyan Zhang, Xianghui Qi. (2026) Rational metabolic reprogramming of yeast across multiple pathway nodes for de novo liquiritigenin biosynthesis from glucose. Food Bioscience, [10.1016/j.fbio.2026.109513]