计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
2-8°C储存,避光,干燥。低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
IDO2-IN-1 is an orally active and potent Indoleamine 2,3-dioxygenase 2 ( IDO2 ) inhibitor with an IC 50 value of 112 nM. IDO2-IN-1 can be used for inflammatory autoimmunity research
In Vitro
IDO2-IN-1 (compound 22) shows stronger inhibition on IDO2 (IC 50 =112 nM) over IDO1 (IC 50 =411 nM). IDO2-IN-1 inhibits hIDO1 expression (EC 50 =633 nM) in HeLa cell-based IDO1/kynurenine assay, co-incubated with hIFN-γ (100 ng/mL final concentration), which is used for producing N-formylkynurenine. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HeLa cells line expressing hIDO1 induced by IFN-γ Concentration: 1 nM-0.1 mM Incubation Time: 48 hours Result: Showed additional potency against IDO1 with an EC 50 value of 633 nM.
In Vivo
The Adjuvant arthritis (AA) model and Collagen-induced arthritis (CIA) model have similar pathogenesis and pathological characteristics to human rheumatoid arthritis (RA). IDO2-IN-1 (compound 22) (100 mg/kg; p.o.; once dose) exhibits excellent anti-inflammatory activity, higher than naproxen, a prescription drug reducing pain, swelling, and joint stiffness from arthritis . IDO2-IN-1 (25, 50, 100 mg/kg; i.p.; once daily, for 19 d) exhibits excellent inhibitory effect on mice paw swelling, shows efficacy in a collagen-induced arthritis model in mice . IDO2-IN-1 (30, 60, 120 mg/kg; i.p.; once daily, for 15 d) inhibits joint inflammation and displays potential effect in autoimmune arthritis improvement . Pharmacokinetic Profile in Rat Route Dose (mg/kg) T 1/2/sub> (h) T max (h) C max (ng/mL) AUC (0-∞) (h•ng/mL) CL (mL/h/kg) V z (mL/kg) MRT (0-∞) (h) F (%) i.v. 1 0.69 / / 375.1 2673 2675 0.55 / p.o. 10 2.02 0.75 153.8 670.5 / / 7.48 17.87 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Xylene-induced ear swelling mouse model (ICR mice, male, 6 weeks old) Dosage: 100 mg/kg Administration: Oral gavage; once dose; evenly coated right ear with 25 μL of xylene after 1 h treatment Result: Significantly relieved mouse ear swelling with a high swelling inhibition rate of 65.32%. Animal Model: Collagen-induced arthritis (CIA) mice model (DBA/1J mice, male, 6 weeks old) Dosage: 25, 50, 100 mg/kg Administration: Intraperitoneal injection; once daily; 19 days, began on day 56 after collagen induced Result: Decreased the expression of inflammatory cytokines IL-18 and IL-33. Reduced inflammation and cartilage and bone erosions symptoms. Animal Model: Adjuvant arthritis (AA) rat model (Sprague-Dawley rats, male, 180 ± 20 g) Dosage: 30, 60, 120 mg/kg Administration: Intraperitoneal injection; once daily; 15 days, began on day 21 after chondrex induced Result: Significantly reduced IL-6 and TNF-α levels. Decreased synovial hyperplasia accompanied by inflammatory cell infiltration, pannus formation, and bone erosion of cartilage in a dose-dependent manner.
Form:Solid
IC50& Target:IDO1 411 nM (IC 50 ) IDO2 112 (IC 50 )
规格
规格或纯度
≥98%
英文名称
IDO2-IN-1
生化机理
IDO2-IN-1 是一种口服活性强效吲哚胺 2,3-二氧合酶 2（IDO2）抑制剂，IC 50 值为 112 nM。IDO2-IN-1 可用于炎症性自身免疫研究。
储存条件
2-8°C储存,避光,干燥
运输条件
低温运输
作用类型
抑制剂
纯度
≥98%
名称和识别符
分子类型
小分子
分子量
541.36
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 140 mg/mL (258.61 mM; Need ultrasonic)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
常见问题
本产品的纯度是多少？
本产品的化学纯度（含量）为 ≥98%。批次的具体数值以分析证书（COA）为准。
本产品应如何储存？
请于2–8 °C、避光、干燥条件下保存。请与干燥剂一同密封保存，本品对湿气敏感。
本产品如何运输？
本产品采用湿冰冷藏运输。收货后请立即拆包，并按上述储存条件保存。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 2803768-09-2，分子式为 C21H21BrN10O3，分子量为 541.36 g/mol。
如何获取批次专用COA？
每个订单都会随附分析证书（COA），您也可以从账户订单历史中下载。如需订购前的COA，请联系您的客户代表，或使用PDP上的"申请COA"按钮——我们将提供代表性批次的COA。
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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