计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
2-8°C储存,干燥。低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Iptakalim hydrochloride, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (K ATP ) opener, as well as an α 4 β 2 -containing nicotinic acetylcholine receptor (nAChR) antagonist.
In Vitro
Iptakalim (Ipt) hydrochloride has been shown to reverse pulmonary resistance vascular remodeling, inhibit proliferation of pulmonary arterial smooth muscle cells (PASMCs) and airway smooth muscle cells (ASMCs), as well as protect PAECs from pathological stimulation. Iptakalim has an inhibitory effect on [Ca 2+ ]cyt increase and the proliferation of pulmonary arterial SMCs induced by endothelin-1 through activation of K ATP channels. Iptakalim (10 μM, 10 min) pretreatment of pulmonary arterial SMCs significantly prevents ransient ncrease of [Ca 2+ ]cyt elicited by endothelin-1. Iptakalim at he concentrations of 0.1, 1, and 10 AM lowered[3H]thymidine incorporation by 19.75±4.60% (n=10), 41.20±9.49% (n=10), and 54.74±10.11% (n=10), respectively, compared with that of cells treated only with endothelin-1. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Iptakalim (10-60 mg/kg) attenuates nicotine-evoked conditioned responding. Iptakalim also attenuates chamber activity in these nicotine test sessions. .\nIptakalim (60 mg/kg) pretreatment significantly reduced activity (LSD comparisons). . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Thirty male Sprague-Dawley rats weighing 275-299 grams. Dosage: 0, 10, 30, or 60 mg/kg. Administration: IP, 10 min before the start of a 4-min test session. Result: Decreased chamber activity. Dipper entries following pretreatment with 30 and 60 mg/kg Iptakalim were significantly lower than with 0 (saline) or 10 mg/kg iptakalim pretreatment (Tukey HSD tests).
Form:Solid
规格
别名
盐酸埃他卡林
规格或纯度
≥98%
英文名称
Iptakalim hydrochloride
生化机理
盐酸伊普卡利姆是一种亲脂性对氨基化合物，是一种新型 ATP 敏感钾通道（K ATP）开启剂，也是α 4 β 2 含烟碱乙酰胆碱受体（nAChR）拮抗剂。
储存条件
2-8°C储存,干燥
运输条件
低温运输
作用类型
激活剂
纯度
≥98%
名称和识别符
技术文档
高级数据
化学和物理性质
溶解性
H2O : 25 mg/mL (139.10 mM; ultrasonic and warming and heat to 70°C)
分子量
179.730 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count
2
氢键受体数Hydrogen Bond Acceptor Count
1
可旋转键计数Rotatable Bond Count
3
精确质量Exact Mass
179.144 Da
单同位素质量Monoisotopic Mass
179.144 Da
拓扑极表面积Topological Polar Surface Area
12.000 Ų
重原子数Heavy Atom Count
11
形式电荷Formal Charge
0
复杂度Complexity
92.900
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
2
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
常见问题
本产品的纯度是多少？
本产品的化学纯度（含量）为 ≥98%。批次的具体数值以分析证书（COA）为准。
本产品应如何储存？
请于2–8 °C、干燥条件下保存。请与干燥剂一同密封保存，本品对湿气敏感。
本产品如何运输？
本产品采用湿冰冷藏运输。收货后请立即拆包，并按上述储存条件保存。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 642407-63-4，分子式为 C9H22ClN，分子量为 179.73 g/mol。
如何获取批次专用COA？
每个订单都会随附分析证书（COA），您也可以从账户订单历史中下载。如需订购前的COA，请联系您的客户代表，或使用PDP上的"申请COA"按钮——我们将提供代表性批次的COA。
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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