计算溶液所需的质量、体积或浓度。
JTV-519 hemifumarate
有货
为什么选择此级别
Moligand™ 级 提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
JTV-519 hemifumarate (K201 hemifumarate) is a Ca 2+ -dependent blocker of sarcoplasmic reticulum Ca 2+ -stimulated ATPase ( SERCA ) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties.
In Vitro
JTV-519 (K201) inhibits inward Ca 2+ movement into large unilamellar vesicles (LUV) caused by annexin V in a dose-dependent manner. In the presence of 50 nM annexin V and 400 μM Ca 2+ , 3 μM JTV-519 shows significant inhibition of Ca 2+ movement due to annexin V, and 50% inhibition is achieved at 25 μM K201. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
JTV-519 (0.5mg/kg/h, i.v., 2 h before the surgery) improves cardiac function in CLP mice, where the fractional shortening (FS) and ejection fraction (EF) are significantly increased as compared with CLP mice without JTV-519 treatment. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Wild type male C57BL/6 mice weighing 18-22g with polymicrobial sepsis produced by cecal ligation and puncture (CLP)Dosage: 0.5 mg/kg/h Administration: Applied intraperitoneally 2 h before the surgery Result: Improved cardiac function, where the EF and FS were significantly increased.
Form:Solid
规格
别名
JTV-519 半富马酸盐
英文别名
K201 hemifumarate
规格或纯度
Moligand™, ≥98%
英文名称
JTV-519 hemifumarate
生化机理
JTV-519 hemifumarate（K201 hemifumarate）是肌浆网 Ca 2+ 刺激 ATP 酶（SERCA）的 Ca 2+ 依赖性阻断剂，也是横纹肌中雷诺丁受体的部分激动剂。具有抗心律失常和保护心脏的特性。
储存条件
-20°C储存
运输条件
超低温运输
作用类型
抑制剂
纯度
≥98%
名称和识别符
分子类型
小分子
分子量
482.64
技术文档
高级数据
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