计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
KRN5, a derivative of KRN2, is an oral active Nuclear factor of activated T cells 5 (NFAT5) suppressor, with an IC 50 of 750 nM. KRN5 has potential to treat NFAT5-mediated Chronic Arthritis
In Vitro
KRN5 is less toxic than BBR as determined by a cytotoxicity assay, hERG K+ channel assay, cytochrome inhibition assay, and liver microsomal metabolic stability test, which makes it a potential drug candidate. KRN5 at a concentration of 1 μM inhibits the expressions of NFAT5, IL-6,MCP-1, and GM-CSF,which are NFAT5 target molecules, in RAW264.7 macrophages stimulated with LPS. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Oral feeding of KRN5 (15 mg/kg and 60 mg/kg) every other day for 3 weeks from day 21 dose-dependently mitigates arthritis severity . The concentration of serum anti-type II collagen IgG also significantly decreases in the sera of KRN5-treated mice. TNF-α and IL-6 production by LPS-stimulated splenocytes are significantly lower in KRN5-treated CIA mice than in vehicle-treated mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 8-week-old DBA/1Jmice immunized with bovine type II collagen . Dosage: 15 mg/kg and 60 mg/kg. Administration: Orally on alternate days (every other day) for 3 weeks. Result: Dose-dependently mitigated arthritis severity.
Form:Solid
IC50& Target:IC50: 750 nM (NFAT5)
规格
规格或纯度
≥98%
英文名称
KRN5
生化机理
KRN5 是 KRN2 的衍生物，是一种口服活性活化 T 细胞核因子 5 (NFAT5) 抑制剂，IC50 为 750 nM。KRN5 具有治疗 NFAT5 介导的慢性关节炎的潜力。
储存条件
-20°C储存
运输条件
超低温运输
纯度
≥98%
名称和识别符
分子类型
小分子
Smiles
COC1=C(C2=C(C=C1)C(=C3C4=CC5=C(C=C4CCN3C2=O)OCO5)CC6=CC=CC=C6F)OC
Isomeric SMILES
COC1=C(C2=C(C=C1)C(=C3C4=CC5=C(C=C4CCN3C2=O)OCO5)CC6=CC=CC=C6F)OC
PubChem CID
分子量
459.47
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 5 mg/mL (10.88 mM; ultrasonic and warming and heat to 80°C)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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