limertinib (ASK120067) diTFA is a potent and orally active inhibitor of EGFR T790M ( IC 50 : 0.3 nM) with selectivity over EGFR WT ( IC 50 : 6.0 nM). limertinib diTFA is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC).