| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| L408943-1ml |
1ml |
现货  |
|
| 别名 | 利奈唑胺（PNU-100766） |
|---|---|
| 英文别名 | (S)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Linezolid (PNU-100766) |
| 生化机理 | 利奈唑胺（PNU-100766）是一种合成抗生素，用于治疗严重感染。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 细菌 70S 核糖体抑制剂 |
| 产品介绍 |
Linezolid 是一种合成的抗生素，用于治疗严重感染。（仅用于科研）抑制细菌mRNA翻译.（仅用于科研） Information Linezolid (PNU-100766) is a synthetic antibiotic used for the treatment of serious infections. Linezolid inhibits initiation complex formation with either the 30S or the 70S ribosomal subunits from Escherichia coli. Linezolid inhibits complex formation with Staphylococcus aureus 70S tight-couple ribosomes. Linezolid is a potent inhibitor of cell-free transcription-translation in E. coli, exhibiting 50% inhibitory concentrations (IC50s) of 1.8 mM. Linezolid\xa0is an oxazolidinone, a new class of antibacterial agents with enhanced activity\xa0against\xa0pathogens. Linezolid MICs vary slightly with the test method, laboratory, and significance attributed to thin hazes of bacterial survival, but all workers find that the susceptibility distributions are narrow and unimodal, with MIC values between 0.5 and 4 mg/L for streptococci, enterococci and staphylococci. Linezolid entails mutation of the 23S rRNA that forms the binding site. Linezolid is an oxazolidinone whose mechanism of action involves inhibition of protein synthesis at a very early stage. Linezolid is added to 7H10 agar medium (Difco) supplemented with OADC (oleic acid, albumin, dextrose, and catalase) at 50°C to 56°C by doubling the dilutions to yield a final concentration of 0.125 μg/mL to 4 μg/mL. Linezolid shows excellent in vitro activity against all the strains tested (MICs ≤ 1 μg/ml), including those resistant to SIRE. In vivo
cell lines：U87, LN229, NIH3T3, HUVECs, BaF3 and TT thyroid carcinoma cells Concentrations： Incubation Time： Powder Purity:≥99% |
| ALogP | 0.894 |
|---|---|
| hba_count | 4 |
| HBD Count | 1 |
| Rotatable Bond | 4 |
| Canonical SMILES | CC(=O)NCC1CN(C(=O)O1)C2=CC=C(N3CCOCC3)C(=C2)F |
|---|---|
| 分子量 | 337.35 |
| Reaxy-Rn | 9426017 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9426017&ln= |
| DMSO(mg / mL) Max Solubility | 67 |
|---|---|
| DMSO(mM) Max Solubility | 198.61 |
| Water(mg / mL) Max Solubility | <1 |
| Reaxy-Rn | 9426017 |
|---|---|
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9426017&ln= |
| Concentration(Compounding value) | 9-11(mmol/L) |
|---|---|
| Record the entire process by video | Conform |
首页
400-620-6333
