计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
2-8°C储存,避光,干燥。低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
LDC4297 hydrochloride is a selective inhibitor of CDK7 with an IC 50 value of 0.13 nM. LDC4297 hydrochloride inhibits human cytomegalovirus (HCMV) replication with an EC 50 value of 24.5 nM. LDC4297 hydrochloride shows broad antiviral activities to Herpesviridae , Adenoviridae , Poxviridae , Retroviridae and Orthomyxoviridae with EC 50 values of 0.02-1.21 μM. LDC4297 hydrochloride can be used for the research of infection
In Vitro
LDC4297 hydrochloride (0-10 μM; 6 d) dose-dependently inhibits HCMV replication with an EC 50 value of 24.5 nM. LDC4297 hydrochloride (0-10 μM; 4 d) shows anti-proliferative activity to primary cultures of fibroblasts derived from human (HFF) with a GI 50 value of 4.5 μM. LDC4297 hydrochloride (20 μM; 12-96 h) shows anti-HCMV activity through a multifaceted mode of action that involves an interference with virus-induced Rb phosphorylation. LDC4297 hydrochloride (0-10 μM; 7 d) shows broad antiviral activities to HCMV, GPCMV, MCMV, HVV-6A, HSV-1, HSV-2, VZV, EBV, HAdV-2, Vaccinia virus, HIV-1 (nl4-3), HIV-1 (4LIG7) and Influenza A virus with EC 50 values of 0.02, 0.05, 0.07, 0.04, 0.02, 0.27, 0.06, 1.21, 0.25, 0.77, 1.04, 1.13 and 0.99 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Primary cultures of fibroblasts derived from human (HFF) with virus infection Concentration: 20 μM Incubation Time: 12, 24, 48 and 96 hours Result: Showed inhibitory effect towards viral protein synthesis at the stage of immediate early (IE) gene expression and the drug-mediated reduction of IE1p72 levels partially recovered over time. Exerted an inhibitory effect on human cytomegalovirus (HCMV) induced an up-regulation of protein expression or protein phosphorylation, and reduced Rb expression in the uninfected control cells at 24 h.
In Vivo
LDC4297 hydrochloride (100 mg/kg; p.o. once) shows promising pharmacokinetic analyses . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: CD1 mice Dosage: 100 mg/kg Administration: Oral gavage; 100 mg/kg once Result: Showed a half-life (t1/2z) of 1.6 h, and the time to a mean peak plasma concentration of 1297.6 ng/mL is reached 0.5 h after administration with a continued presence in plasma for at least 8 h and a bioavailability of 97.7%.
Form:Solid
IC50& Target:CDK7 0.13 nM (IC 50 ) 166v VP22-GFP 0.02 μM (EC 50 ) 01-6332 0.27 μM (EC 50 ) HIV-1 (NL4.3 strain) 1.04 μM (EC 50 ) 4LIG7 1.13 μM (EC 50 )
规格
别名
LDC4297 盐酸盐
规格或纯度
≥98%
英文名称
LDC4297 hydrochloride
生化机理
LDC4297 盐酸盐是 CDK7 的选择性抑制剂，IC 50 值为 0.13 nM。LDC4297 盐酸盐可抑制人类巨细胞病毒（HCMV）的复制，其 EC 50 值为 24.5 nM。LDC4297 盐酸盐对疱疹病毒（HCMV）具有广泛的抗病毒活性。
储存条件
2-8°C储存,避光,干燥
运输条件
低温运输
作用类型
抑制剂
纯度
≥98%
名称和识别符
分子类型
小分子
分子量
468.98
技术文档
高级数据
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
常见问题
本产品的纯度是多少？
本产品的化学纯度（含量）为 ≥98%。批次的具体数值以分析证书（COA）为准。
本产品应如何储存？
请于2–8 °C、避光、干燥条件下保存。请与干燥剂一同密封保存，本品对湿气敏感。
本产品如何运输？
本产品采用湿冰冷藏运输。收货后请立即拆包，并按上述储存条件保存。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 2319747-14-1，分子式为 C23H29ClN8O，分子量为 468.98 g/mol。
如何获取批次专用COA？
每个订单都会随附分析证书（COA），您也可以从账户订单历史中下载。如需订购前的COA，请联系您的客户代表，或使用PDP上的"申请COA"按钮——我们将提供代表性批次的COA。
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 保留所有权利。
危险品化学品经营许可证（带存储）