计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥97% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
LFHP-1c is an PGAM5 inhibitor with neuroprotective activity in brain ischemic stroke. LFHP-1c protects blood-brain barrier integrity from ischemia-induced injury. LFHP-1c binds to endothelial PGAM5 to inhibit the activity of PGAM5 phosphatase and the interaction of PGAM5 with NRF2. LFHP-1c exhibits in vitro and in vivo protection.
In Vitro
LFHP-1c (1, 2, or 5 μmol/L; 9 h) treatment, and followed by hypoxic treatment, increases NRF2 protein expression and facilitates nuclear translocation of NRF2 in primary rat brain microvascular endothelial cells (rBMECs). MCE has not independently confirmed the accuracy of these methods. They are for reference only. ImmunofluorescenceCell Line: Primary rat brain microvascular endothelial cells (rBMECs) Concentration: 2 μmol/L Incubation Time: 1 h Result: Bound to PGAM5, to facilitate nuclear translocation of NRF2.
In Vivo
LFHP-1c (5 mg/kg; iv; 2 doses) prevents BBB disruption after transient middle cerebral artery occlusion (tMCAO) in rats . LFHP-1c (3 mg/kg, 1 mL/kg; iv; 8 doses) ameliorates brain ischemic injury in tMCAO model of M. fascicularis through PGAM5–NRF2 axis . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Nonhuman primate Macaca fascicularis model with tMCAO Dosage: 3 mg/kg, 1 mL/kg Administration: IV; at 4 h, 1, 2, 3, 4, 5, 6 and 7 days after tMCAO onset. Result: Reduced infarct volume, brain edema and neurological deficits in Transient MCAO model in M. fascicularis. Animal Model: SD rats (230-250 g) Dosage: 1 mg/kg, 5 mg/kg in 0.5 mL volume Administration: IV; injected at 4 or 12 h after ischemia onset, and then injected another time at 24 h post-ischemia Result: Dose-dependently protected rat brains against ischemia/reperfusion injury at 72 h after ischemia onset with a moderate therapeutic window. Prevented BBB disruption and attenuated endothelial inflammation in rat cerebral microvessels at 72 h after ischemia onset.
Form:Solid
规格
规格或纯度
≥97%
英文名称
LFHP-1c
生化机理
LFHP-1c 是一种 PGAM5 抑制剂，对脑缺血中风具有神经保护活性。LFHP-1c 可保护血脑屏障的完整性，防止缺血引起的损伤。LFHP-1c 可与内皮细胞的 PGAM5 结合，抑制 PGAM5 磷酸酶的活性，并抑制血脑屏障的完整性。
储存条件
-20°C储存
运输条件
超低温运输
作用类型
抑制剂
纯度
≥97%
名称和识别符
分子类型
小分子
分子量
873.13
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 100 mg/mL (114.53 mM; Need ultrasonic)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
常见问题
本产品应如何储存？
请于?20 °C条件下保存。需冷冻保存以维持规定的有效期。
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