计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥97% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
避光,-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
L48H37 is an analog of Curcumin with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is used for the research of sepsis or lung injury treatment
In Vitro
L48H37 inhibits LPS-induced inflammation, particularly TNF-α and IL-6 production and gene expression in mouse macrophages. L48H37 (0-20 µM; 24 hours) decreases the viability of A549 and H460 cells with IC 50 values of 5.3 µM and 2.3 µM, respectively, which is more effective compared to curcumin in lung cancer cells. It shows a low cytotoxicity on normal human lung epithelial cells (BEAS-2B) with IC 50 of 21 μM. L48H37 (1, 2, or 4 µM; 16 hours) dose‐dependently inhibited the expression of p‐Cdc2 and Cdc2, and increases the expression of p53. It also shows increased levels of cleaved poly (ADP‐ribosyl) polymerase (PARP) and reduced levels of anti‐apoptotic protein Bcl‐2 in H460 and A549 cells. L48H37 (4 µM; 16 hours) rapidly induces intracellular ROS levels dose-dependently as detected by increased DCF levels in H460 and A549 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: A549 and H460 cells; BEAS-2B cells Concentration: 0.625, 1.25, 2.5, 5, 7.5, 10, and 20 µM Incubation Time: 24 hours Result: Inhibited lung cancer cells growth in a concentration-dependent manner. Western Blot AnalysisCell Line: A549 and H460 cells Concentration: 0.625, 1.25, 2.5, 5, 7.5, 10, and 20 µM Incubation Time: 24 hours Result: Decreased p‐Cdc2, Cdc2, and Bcl‐2 expression in 2 lung cancer cells.
In Vivo
L48H37 (intraperitoneal injection; 5 mg or 10 mg/kg; once daily; 11‐day ) inhibits H460 xenograft tumor growth and exhibits anti‐tumor activity in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 5‐week‐old athymic BALB/cA nu/nu female mice (18‐22 g)Dosage: 5 mg or 10 mg/kg Administration: Intraperitoneal injection; once daily; 11‐day Result: Reduced tumor wet weights as compared to vehicle control. Decreased the levels of p‐STAT3, and increased the levels of p‐EIF2α and ATF4 in vivo. Exhibited no significant structural changes in mice.
Form:Solid
IC50& Target:TLR4
规格
规格或纯度
≥97%
英文名称
L48H37
生化机理
L48H37 是姜黄素（HY-N0005）的类似物，具有更好的化学稳定性。L48H37 是一种强效的特异性髓系分化蛋白 2（MD2）抑制剂，可抑制 LPS-TLR4/MD2 的相互作用和信号转导。L48H37 可用于
储存条件
避光,-80℃储存
运输条件
特低温运输
作用类型
抑制剂
纯度
≥97%
名称和识别符
分子类型
小分子
Isomeric SMILES
CCN1CC(=CC2=CC(=C(C(=C2)OC)OC)OC)C(=O)C(=CC3=CC(=C(C(=C3)OC)OC)OC)C1
PubChem CID
分子量
483.55
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 50 mg/mL (103.40 mM; Need ultrasonic)
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
常见问题
本产品的纯度是多少？
本产品的化学纯度（含量）为 ≥97%。批次的具体数值以分析证书（COA）为准。
本产品应如何储存？
请于?80 °C、避光条件下保存。本品对光敏感，请保存在原始的避光或棕色容器中。
本产品如何运输？
本产品采用干冰配冷袋冷冻运输。收货后请立即拆包，并按上述储存条件保存；处理干冰时请戴隔热手套并保持通风。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 343307-76-6，分子式为 C27H33NO7，分子量为 483.55 g/mol。
如何获取批次专用COA？
每个订单都会随附分析证书（COA），您也可以从账户订单历史中下载。如需订购前的COA，请联系您的客户代表，或使用PDP上的"申请COA"按钮——我们将提供代表性批次的COA。
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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