G2418626计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存,干燥。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
LDN193189 Tetrahydrochloride is a selective BMP type I receptor inhibitor, which efficiently inhibits ALK2 and ALK3 ( IC 50 =5 nM and 30 nM, respectively), with weaker effects on ALK4 , ALK5 and ALK7 (IC 50 ≥500 nM)
In Vitro
LDN193189 inhibits BMP4-mediated Smad1, Smad5 and Smad8 activation with great potency (IC 50 =5 nM) while retaining 200-fold selectivity for BMP signaling versus TGF-β signaling (IC 50 for TGF-β ≥1,000 nM). LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 (IC 50 =5 nM and 30 nM, respectively), and the TGF-β type I receptors ALK4, ALK5 and ALK7 (IC 50 ≥500 nM) and increases selectivity for BMP signaling versus AMP-activated protein kinase, PDGFR and MAPK signaling pathways as compared to the parent compound. LDN193189 blocks the transcriptional activity induced by either constitutively active ALK2 R206H or ALK2 Q207D mutant proteins. LDN193189 inhibits the induction of alkaline phosphatase activity in C2C12 cells by BMP4 even when administered 12 h after BMP stimulation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
LDN193189 (Tetrahydrochloride) (i.p.;3 mg/kg;twice a day) shows the growth rates between the control vehicle- and LDN193189-treated mice are not significantly different after the first 5 weeks, but differences in the growth rates are detected after 6 and 7 weeks post-treatment. LDN193189 (s.c;5 days) shows significantly the difference of tumor size at 6 and 7 weeks post-treatment and the tumor weights also show significant differences at the termination of the study at week 7. LDN193189 reduces the ectopic bone volume and bone density. LDN193189 completely inhibited the anti-proliferation and up-regulation of the bone morphogenetic protein (BMPR2) and Cx40 expression co-incubation with UK-92480. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:ACVR1 5 nM (IC 50 ) BMPR1A 30 nM (IC 50 )
规格
别名
LDN193189 四盐酸盐
英文别名
DM-3189 Tetrahydrochloride
规格或纯度
≥98%
英文名称
LDN193189 Tetrahydrochloride
生化机理
LDN193189 Tetrahydrochloride 是一种选择性 BMP I 型受体抑制剂，可有效抑制 ALK2 和 ALK3（IC 50 分别为 5 nM 和 30 nM），对 ALK4、ALK5 和 ALK7 的作用较弱（IC 50 ≥500 nM）。
储存条件
-20°C储存,干燥
运输条件
超低温运输
作用类型
抑制剂
纯度
≥98%
名称和识别符
技术文档
高级数据
化学和物理性质
溶解性
H2O : 33.33 mg/mL (60.34 mM; Need ultrasonic) DMSO : 4.17 mg/mL (7.55 mM; Need ultrasonic)
敏感性
对湿度敏感
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
常见问题
本产品的纯度是多少？
本产品的化学纯度（含量）为 ≥98%。批次的具体数值以分析证书（COA）为准。
本产品应如何储存？
请于?20 °C、干燥条件下保存。请与干燥剂一同密封保存，本品对湿气敏感。
本产品如何运输？
本产品采用保温箱配冰袋运输。收货后请立即拆包，并按上述储存条件保存。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 2310134-98-4，分子式为 C25H26Cl4N6，分子量为 552.33 g/mol。
如何获取批次专用COA？
每个订单都会随附分析证书（COA），您也可以从账户订单历史中下载。如需订购前的COA，请联系您的客户代表，或使用PDP上的"申请COA"按钮——我们将提供代表性批次的COA。
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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危险品化学品经营许可证（带存储）