Difunctional Fluorescent Probes for Iron and Hydrogen Sulfide Detection Based on Diphenyl Derivative

In order to better monitor the content of Fe 3+ and H 2 S in the biological environment, two new fluorescent probes were designed and synthesized. With the addition of Fe 3+ , the strong fluorescence emission of two probes was significantly quenched due to the paramagnetic effect of Fe 3+ . With the further addition of S 2− , the fluorescence intensity was quickly restored. Two probes showed high selectivity and strong sensitivity for the detection of Fe 3+ and S 2− , and the fluorescence intensity “ON-OFF-ON” was accompanied with the interaction process. At the same time, two probes displayed good anti-interference ability which was not interfered by the existence of other ions. In addition, two probes illustrated fast response time to Fe 3+ , S 2− and small cytotoxicity to cells. Therefore, two probes can provide a potential ideal tool for detecting Fe 3+ and H 2 S in organisms and the environment.