Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Xu Yueshan,Wu Daoxiong,Zhang Qinghua,Rao Peng,Deng Peilin,Tang Mangen,Li Jing,Hua Yingjie,Wang Chongtai,Zhong Shengkui,Jia Chunman,Liu Zhongxin,Shen Yijun,Gu Lin,Tian Xinlong,Liu Quanbing
The direct oxidation of methane to methanol under mild conditions is challenging owing to its inadequate activity and low selectivity. A key objective is improving the selective oxidation of the first carbon-hydrogen bond of methane, while inhibiting the oxidation of the remaining carbon-hydrogen bonds to ensure high yield and selectivity of methanol. Here we design ultrathin Pd x Au y nanosheets and revealed a volcano-type relationship between the binding strength of hydroxyl radical on the catalyst surface and catalytic performance using experimental and density functional theory results. Our investigations indicate a trade-off relationship between the reaction-triggering and reaction-conversion steps in the reaction process. The optimized Pd 3 Au 1 nanosheets exhibits a methanol production rate of 147.8 millimoles per gram of Pd per hour, with a selectivity of 98% at 70 °C, representing one of the most efficient catalysts for the direct oxidation of methane to methanol.
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Acta Biomaterialia
·
2024
·
IF 9.4
Zi Qiao,Jie Ding,Mei Yang,Yuchen Wang,Ting Zhou,Yuan Tian,Mingze Zeng,Chengheng Wu,Dan Wei,Jing Sun,Hongsong Fan
Inspired by the strong light absorption of carbon nanotubes, we propose a fabrication approach involving one-dimensional TiO 2 /Bi 2 S 3 QDs nanotubes (TBNTs) with visible red-light excitable photoelectric properties. By integrating the construction of heterojunctions, quantum confinement effects, and morphological modifications, the photocurrent reached 9.22 µA/cm 2 which is 66 times greater than that of TiO 2 nanotubes (TNTs). Then, a red light-responsive photoelectroactive hydrogel dressing (TBCHA) was developed by embedding TBNTs into a collagen/hyaluronic acid-based biomimetic extracellular matrix hydrogel with good biocompatibility, aiming to promote wound healing and skin function restoration. This approach is primarily grounded in the recognized significance of electrical stimulation in modulating nerve function and immune responses. Severe burns are often accompanied by extensive damage to epithelial-neural networks, leading to a loss of excitatory function and difficulty in spontaneous healing, while conventional dressings inadequately address the critical need for nerve reinnervation. Furthermore, we highlight the remarkable ability of the TBCHA photoelectric hydrogel to promote the reinnervation of nerve endings, facilitate the repair of skin substructures, and modulate immune responses in a deep burn model. This hydrogel not only underpins wound closure and collagen synthesis but also advances vascular reformation, immune modulation, and neural restoration. This photoelectric-based therapy offers a robust solution for the comprehensive repair of deep burns and functional tissue regeneration. Statement of significance We explore the fabrication of 1D TiO 2 /Bi 2 S 3 nanotubes with visible red-light excitability and high photoelectric conversion properties. By integrating heterojunctions, quantum absorption effects, and morphological modifications, the photocurrent of TiO 2 /Bi 2 S 3 nanotubes could reach 9.22 µA/cm², which is 66 times greater than that of TiO 2 nanotubes under 625 nm illumination. The efficient red-light excitability solves the problem of poor biosafety and low tissue penetration caused by shortwave excitation. Furthermore, we highlight the remarkable ability of the TiO 2 /Bi 2 S 3 nanotubes integrated photoelectric hydrogel in promoting the reinnervation of nerve endings and modulating immune responses. This work proposes an emerging therapeutic strategy of remote, passive electrical stimulation, offering a robust boost for repairing deep burn wounds.
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American Journal of Translational Research
·
2024
·Vol. 16
·期 10
·5385
·
IF 1.7
Hui Huang,Guanhua Wang,Dali Zeng
Objective: To investigate the protective effect of Peimine (PM) against lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice and the underlying mechanisms. Methods: KM mice were randomly divided into five groups: Control, LPS, Peimine low-dose (PM-L, 0.1 mg/kg), medium-dose (PM-M, 1 mg/kg), and high-dose (PM-H, 10 mg/kg) groups. Mice in the PM treatment groups received intraperitoneal injection of Peimine at different doses, while the mice in control and LPS groups received physiological saline. Afterwards, mice in the LPS and PM groups were subjected to intranasal instillation of LPS to establish the model of acute lung injury. The wet-to-dry (W/D) weight ratio of lung tissues was calculated, and H&E staining was performed to observe pathological changes in the lung tissues. Serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), and MDA were measured using ELISA kits. Western blot was employed to assess the expression of NF-κB, IκBα, phospho-IκBα, Nrf2, HO-1, and SOD2 in lung tissues. RT-PCR quantified the mRNA levels of Nrf2 and its downstream genes HO-1 and NQO1. Additionally, RAW264.7 cells were treated with various drug concentrations for 24 hours followed by LPS exposure (100 ng/mL) for another 24 hours. Prior to treatment of RAW264.7 cells with PM and LPS, the ML385+PM group was pre-treated with ML385 (3 μM) for 4 hours. ELISA kits were used to measure TNF-α, IL-6, IL-1β, and MDA in cell supernatants, while ROS levels were determined using a ROS assay kit. Results: Compared with the model group, pretreatment with PM significantly reduced the lung tissue W/D weight ratio, ameliorated lung tissue pathological changes, and inhibited the secretion of TNF-α, IL-6, and IL-1β in bronchoalveolar lavage fluid. PM inhibited the LPS-induced elevation in lung tissue MDA levels, SOD2 consumption, and ROS levels. Furthermore, PM suppressed LPS-induced NF-κB activation and nuclear translocation, while significantly enhancing the protein expression of Nrf2 and HO-1 and increasing the mRNA levels of Nrf2 and its downstream genes, such as HO-1 and NQO1. In RAW264.7 cells, LPS induction led to elevated IL-1β, IL-6, TNF-α, MDA, and ROS levels, which were significantly suppressed by PM treatment. However, the antioxidative and anti-inflammatory effects of PM were effectively blocked by inhibiting the Nrf2 pathway. Conclusion: PM effectively ameliorates LPS-induced lung injury, primarily through inhibition of the NF-κB pathway, and activation of the Nrf2 pathway, alongside a reduction in the release of inflammatory factors.
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Biomedical Materials
·
2024
·Vol. 19
·期 3
·035009
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IF 3.9
Guancheng Zhan,Lixia Yu,Qiqi Wang,Longyang Jin,Xiaohong Yin,Xiaodong Cao,Huichang Gao
Corneal stromal injury is a common surgical disease. With the development of tissue engineering materials, many artificial corneal scaffolds have been developed to replace allograft corneal transplantation and solve the problem of corneal donor shortage. However, few researchers have paid attention to corneal stromal wound healing. Herein, a nanocomposite of amino modified mesoporous bioactive glass (MBG-NH2) and microRNA-133b (miR-133b) was introduced into the patterned collagen films to achieve corneal stromal injury repair. MBG-NH2 nanoparticles as a nano delivery carrier could efficiently load miR-133b and achieve the slow release of miR-133b. The physicochemical properties of collagen films were characterized and found the microgrooved collagen films loaded with miR-133b@MBG-NH2 nanoparticles possessed similar swelling properties, optical clarity, and biodegradability to the natural cornea. In vitro cell experiments were also conducted and proved that the patterned collagen films with miR-133b@MBG-NH2 possessed good biocompatibility, and miR-133b@MBG-NH2 nanoparticles could be significantly uptake by rabbit corneal stromal cells (RCSCs) and have a significant impact on the orientation, proliferation, migration, and gene expression of RCSCs. More importantly, the patterned collagen films with miR-133b@MBG-NH2 could effectively promote the migration of RCSCs and accelerate wound healing process, and down-regulate the expression levels of α-SMA, COL-I, and CTGF genes associated with myofibroblast differentiation of corneal stromal cells, which has a potential application prospect in the repair of corneal stromal injury.
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Frontiers in Bioengineering and Biotechnology
·
2024
·
IF 4.3
Xuqiang Zou,Bo Xie,Xuelian Peng,Mingjie Lu,Dan Xu,Hongyan Yuan,Yixin Zhang,Di Wang,Manzhu Zhao,Rui Liu,Xiujie Wen
Repairing defects in alveolar bone is essential for regenerating periodontal tissue, but it is a formidable challenge. One promising therapeutic approach involves using a strategy that specifically recruits periodontal ligament cells (PDLCs) with high regenerative potential to achieve in situ regeneration of alveolar bone. In this study, we have created a new type of microsphere conjugated with an antibody to target p75 neurotrophin receptor (p75NTR), which is made of nano-hydroxyapatite (nHA) and chitosan (CS). The goal of this design is to attract p75NTR + hPDLCs selectively and promote osteogenesis. In vitro experiments demonstrated that the antibody-conjugated microspheres attracted significantly more PDLCs compared to non-conjugated microspheres. Incorporating nHA not only enhances cell adhesion and proliferation on the surface of the microsphere but also augments its osteoinductive properties. Microspheres effectively recruited p75NTR + cells at bone defect sites in SD rats, as observed through immunofluorescent staining of p75NTR antibodies. This p75NTR antibody-conjugated nHA/CS microsphere presents a promising approach for selectively recruiting cells and repairing bone defects.
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Pigment & Resin Technology
·
2024
·
IF 1.3
Zhichuang Qi,Jingshan Chen,Zhangmi Huang,Chunyan Hu,Baojiang Liu
PurposeThis paper aims to prepare Poly(Styrene-Butyl acrylate-Methacrylic acid) @Poly Gallic acid-Fe3+photonic crystal composite inks [P(St-BA-MAA)@PGA-Fe3+PCCI, @ means the PGA-Fe3+is loaded on the microspheres] and construct noniridescent structural colors on fabric substrates, with the goal of improving the visibility of structural colors.Design/methodology/approachP(St-BA-MAA)@PGA-Fe3+PCCI were prepared by coating P(St-BA-MAA) microspheres with a metal-polyphenol network formed by gallic acid (GA, C7H6O5) and Fe3+. The assembly effects of the inks were explored under different conditions, including pH, temperature, concentration and surface tension. The optimal self-assembly conditions of the inks were determined using the controlled variable method.FindingsThe results demonstrated the successful preparation of P(St-BA-MAA)@PGA-Fe3+PCCI. The metal polyphenol network film composed of GA and Fe3+was successfully coated on the surface of P(St-BA-MAA) seed microspheres. The assembly mechanism of the inks was investigated, indicating that at a diethylene glycol (DEG, C4H10O3) concentration of 0.3 wt% and pH of 7, bright noniridescent structural colors could be formed on fabric surfaces after self-assembly by PCCI at 60 °C for 10 min. Furthermore, the mechanical fastness of the structural colors was enhanced due to the adherence of the soft shell composed of P(St-BA-MAA) and GA.Originality/valueUtilizing a cost-effective approach and a diverse array of readily available raw materials, we have successfully prepared P(St-BA-MAA)@PGA-Fe3+PCCI, which boasts superior performance and offers fabrics a range of unique coloring styles. This innovation paves the way for potential applications of structural colors in practical production, thereby broadening their realm of utility.
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Bioactive Materials
·
2024
·
IF 18
Jiayi Yuan,Bingbing Sun,Weixing Ma,Chao Cai,Zhenzhen Huang,Peiyi Zhou,Lei Yi,Lubin Liu,Shixuan Chen
Repairing large-area soft tissue defects caused by traumas is a major surgical challenge. Developing multifunctional scaffolds with suitable scalability and favorable cellular response is crucial for soft tissue regeneration. In this study, we developed an orthogonally woven three-dimensional (3D) nanofiber scaffold combining electrospinning, weaving, and modified gas-foaming technology. The developed orthogonally woven 3D nanofiber scaffold had a modular design and controlled fiber alignment. In vitro, the orthogonally woven 3D nanofiber scaffold exhibited adjustable mechanical properties, good cell compatibility, and easy drug loading. In vivo, for one thing, the implantation of an orthogonally woven 3D nanofiber scaffold in a full abdominal wall defect model demonstrated that extensive granulation tissue formation with enough mechanical strength could promote recovery of abdominal wall defects while reducing intestinal adhesion. Another result of diabetic wound repair experiments suggested that orthogonally woven 3D nanofiber scaffolds had a higher wound healing ratio, granulation tissue formation, collagen deposition, and re-epithelialization. Taken together, this novel orthogonally woven 3D nanofiber scaffold may provide a promising and effective approach for optimal soft tissue regeneration.
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FOOD RESEARCH INTERNATIONAL
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2024
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IF 7
Wen Gao,Yang Wang,Fuhao Wang,Xinni Wu,Fuping Lu,Fufeng Liu
Ergothioneine (EGT) is a natural dietary antioxidant derived from certain edible mushrooms, commonly used as a food additive and supplement, but its effects on Parkinson’s Disease (PD) are still unclear. The accumulation of α-synuclein (α-syn) plays a pivotal role in the pathogenesis and development of PD. Here, this study demonstrated that EGT effectively inhibits α-syn aggregation, disrupts mature fibers, and reduces associated cytotoxicity and oxidative stress. The beneficial effects of EGT were confirmed in Caenorhabditis elegans , where it protected dopaminergic neurons, prolonged lifespan and enhanced behavioral functions by reducing α-syn plaque accumulation and associated oxidative stress. Molecular dynamics simulation revealed that EGT interacts directly with α-syn pentamer through van der Waals and electrostatic forces, disrupting the structural stability of the preformed pentamer. Furthermore, animal studies validated that EGT alleviated neuronal damage and improved behavioral deficits by reducing α-syn aggregation, oxidative stress and inflammatory response. In conclusion, EGT presents promising potential as a dietary supplement for preventing and alleviating PD.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2024
·
IF 8.1
Fei Qin,Lin bei,Kashif Naseem,Zhanjun Chen,Guoquan Suo,Adnan Tahir
Hydrolysis of magnesium (Mg) or their composites are considered as an efficient, economical and enabling technique to produce hydrogen (H 2 ). In this study, carbon nano-tube coated with iron carbide (CNT@Fe 3 C) was synthesized and applied as a catalyst to promote hydrolysis of Mg to generate H 2 . Ball milling technique was employed to prepare Mg-Xwt%CNT@Fe 3 C (X = 0.2, 2.0, 5.0 and 10.0) composites for hydrolysis in seawater. Among employed composites, the results demonstrated that the introduction of small amount of CNT@Fe 3 C promote the hydrolysis kinetics of Mg. Particularly, Mg-5.0 wt%CNT@Fe 3 C composite ball milled for 1 h released 866.5 mL/g H 2 with 10072.0 mLg −1 min −1 initial hydrogen generation rate mHGR and demonstrated an excellent composite. Furthermore, activation energy of Mg hydrolysis kinetic dropped to 23.6 kJ/mol. Hence, CNT@Fe 3 C inhibited the magnesium hydroxide (Mg(OH) 2 ) from sticking to the unreacted Mg surfaces, which enhanced its galvanic corrosion and reactivity. In order to develop portable H 2 generators, CNT@Fe 3 C supported Mg system can provide clean H 2 to reduce the adverse environmental effect.
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BIOSENSORS & BIOELECTRONICS
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2014
·
IF 6.451
Xi Dai,Qing-Hua Wu,Peng-Chong Wang,Jie Tian,Yu Xu,Sheng-Qing Wang,Jun-Ying Miao,Bao-Xiang Zhao
Acrylic acid 3-acetyl-2-oxo-2 H-chromen-7-yl ester ( ACA ) was rationally designed and synthesized as a simple and effective fluorescent probe for sensing cysteine with high selectivity and naked-eye detection. The probe can detect cysteine by fluorescence spectrometry with a detection limit of 0.657 μM and can be used with calf serum and in live cell imaging . The conjugate addition/cyclization sequence mechanism of the reaction between ACA and cysteine was confirmed by ESI-MS and fluorescence spectra .
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SENSORS AND ACTUATORS B-CHEMICAL
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2021
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IF 7.46
Tian-Ge Chen,Xiu-Zhi Yang,Ru Sun,Jian-Feng Ge
In this study, two fluorescent probes for efficient detection of peroxycarboxylic acid were designed and synthesized. An OFF–ON probe THPY was composed of Pyonin B skeleton and a thioketone group, while the ratiometric probe THCA was based on 4-methylcoumarin skeleton with a thioester group. Both of them showed good selectivity and sensitivity toward peroxycarboxylic acid over other analytes. Especially, detection systems got good operation in aqueous solution containing common ions. The detection mechanism was achieved via thiocarbonyl oxidative desulfurization, which eliminated the inter system crossing (ISC) effect caused by thiocarbonyl structure. The detection limits of THPY were calculated to be 534 nM for peracetic acid (PAA) and 73.6 nM for m-chloroperoxybenzoic acid (mCPBA), and those of THCA were 216 nM for PAA and 230 nM for mCPBA, respectively. The satisfactory results were obtained in the test of actual samples and test strips. All in all, the research produced an effective and stable detection system for peroxycarboxylic acid, and it also proved the possibility of designing probe by controlling ISC effect.
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TETRAHEDRON
·
2018
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IF 2.377
Qing-He Wang,Zhong-Xiang Zhu,Tiao Huang,Ming-Shu Wu
A new rearrangement of isatin-derived N,N′-cyclic azomethine imines to afford intermediate 3-hydroxy-1H-pyrazole -substituted oxindole was found, and then Michael addition of them to a vinyl bisphosphonate ester provided 3,3-disubstituted oxindole-fused pyrazolidone derivatives containing bisphosphonates in the presence of the readily available DMAP. This transformation is particularly attractive due to features such as unexpected rearrangement, mild conditions, atom economy, the ready availability of the starting materials.
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