ADVANCED COMPOSITE MATERIALS
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2025
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IF 2.3
Wenbin Huang,Mengqi Duan,Yongjie Yan,Qingqing Ni,Xiaoming Qi,Lu Xu
Carbon nanotube fibers (CNTF) have great application potential in flexible electronics, smart wearables, bioelectrodes due to their excellent mechanical/electrical properties. However, CNTF is assembled by a large number of CNT monomers, and loose combination of these monomers usually weakens its mechanical/electrical properties. In this study, referring to the principle of carbon fiber precursor carbonization, the carbonization of PAN (polyacrylonitrile) was used to encapsulate and fix the CNTF precursor prepared by floating catalytic chemical vapor deposition to enhance CNTF mechanical performance. Firstly, PAN with different mass fraction was selected as sizing agent to treat the twisted fiber(CPAN@CNTF), then carbonized heat treatment was carried out at different temperatures. Through analyzing the enhancement effect of the structural changes of PAN on the mechanical/electrical properties of CNTF under different conditions, then, the mechanical properties of CNTF reached the best when the PAN sizing amount was 10 wt.% and the heat treatment temperature was 320ºC, and the breaking strength of CNTF was increased to 480 MPa, which was 44% higher than that of untreated CNTF group. It is found that the elastic recovery degree of slurry CPAN@CNTF is excellent through thermomechanical stretching, indicating that PAN after pre-oxidation and low temperature carbonization has a stable effect on the structure of CNTF.
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ANALYTICAL LETTERS
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2025
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IF 1.8
Xuemei Wang,Xue Zhang,Yunsheng Shang,Guohai Yang,Xin Zhang,Lu-Lu Qu,Yingqiu Gu
Surface-enhanced Raman spectroscopy (SERS) is a powerful tool for the rapid, real-time monitoring of trace aquatic pollutants. However, a major challenge persists in the development of SERS substrates capable of simultaneously determining and degrading pollutants. Herein, a highly sensitive Au/TiO2/Au sandwich-structured substrate was fabricated that exhibited excellent SERS performance with an enhancement factor (EF) of 1.05 × 107. Limits of detection (LODs) as low as 1.42 × 10−7 M for ofloxacin (OFL) and 1.26 × 10−9 M for trimethoprim (TMP) were achieved. Notably, the substrate retained stable SERS activity even after five consecutive detect-degrade cycles. By integrating plasmonic enhancement (for SERS detection) with photocatalytic degradation (for pollutant removal), this dual-functional platform demonstrated high reproducibility, with a relative standard deviation (RSD) below 6%, and long-term stability, retaining 60% of its initial SERS intensity after 60 days of storage. The strategy reported herein provides a practical approach for the simultaneous determination and degradation of antibiotics in aqueous matrices.
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Bioanalysis
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2025
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IF 1.8
You-Rim Lee,Jae Guk Kim,Soo Joo Lee,Jiyeong Lee,Hee-Gyoo Kang
Aim Ischemic stroke (IS) occurs when a clot obstructs cerebral blood flow, leading to potentially irreversible damage. Metabolites, as the end products of cellular metabolism, can reflect pathological changes in the body. This study aimed to characterize serum metabolic alterations associated with acute ischemic stroke.Method Participants were divided into discovery and validation sets, each comprising healthy controls and IS patients. In the discovery set, untargeted serum metabolomic profiling was performed using liquid chromatography – tandem mass spectrometry. Metabolites showing significant intergroup differences were selected as biomarker candidates and quantitatively validated in the independent set. Diagnostic performance was assessed using receiver operating characteristic (ROC) curve analysis.Results Three metabolites – cytidine, decanoyl-L-carnitine, and 2-hydroxyestradiol – were identified as significantly altered in IS patients. Cytidine and 2-hydroxyestradiol demonstrated excellent diagnostic performance (AUCs of 0.968 and 0.929, respectively), while decanoyl-L-carnitine showed good performance (AUC = 0.808).Conclusion The three metabolites exhibit significant alterations in acute ischemic stroke patients and provide insight into disease-associated metabolic changes. Their validation lays the groundwork for future exploratory studies investigating potential biomarkers.
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JOURNAL OF DRUG TARGETING
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2025
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IF 3.9
Hong Chen,Michael Adu-Frimpong,Lili Yuan,Yaping Yang,Jollibekov Berdiyar,Jiangnan Yu,Xia Cao,Qilong Wang,Ximing Xu
Astragaloside, a natural flavonol glycoside isolated from plants, exhibits significant tumour-suppressive activity. However, its low solubility and poor bioavailability have hindered its practical application. To improve its bioavailability and therapeutic efficacy, this study prepared Ast-loaded Soluplus/TPGS/Gas hybrid polymer micelles (Ast-STG-M) via the thin-film hydration method. The resulting Ast-STG-M nanoparticles were spherical and uniformly dispersed, characterised by a small particle size (50.92 ± 0.13 nm) and a high encapsulation efficiency (95.24 ± 0.53%). In vitro release profiles demonstrated that the cumulative release rate of Ast from Ast-STG-M was higher than that of free Ast under various pH conditions. After oral administration, compared with free Ast, Ast-STG-M exhibited delayed in vivo elimination and significantly increased bioavailability. Furthermore, results from in vitro and in vivo anti-tumour studies indicated that Ast-STG-M could significantly inhibit the viability of TPC-1 cells, thereby effectively suppressing the growth of solid tumours. In conclusion, Ast-STG-M holds substantial potential as a delivery system for Ast to tumour sites, which not only enhances the oral bioavailability of Ast but also strengthens its anti-cancer activity.
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International Journal of Nanomedicine
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2025
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IF 6.5
Mengya Jin,Jinming Liu,Mengliu Shao,Shaoqin He,Yue He,Qingliang Yang,Gensheng Yang
Background/Objective Pulmonary fibrosis is a chronic, progressive lung disease with a high mortality rate. Currently, the treatment options for IPF involve the oral administration of nintedanib (NDNB); however, these therapies are hampered by low oral bioavailability. This study aimed to develop chitosan-based nanoparticles for pulmonary delivery to enhance the therapeutic effects of curcumin (Cur) and NDNB.Methods We successfully prepared and optimized Cur-loaded chitosan nanoparticles (Cur/CS-VES NPs) and NDNB-loaded chitosan nanoparticles (NDNB/CS-PGA NPs) through a standardized process. In vitro, Calu-3 and HFL1 cells were treated to evaluate the biocompatibility of chitosan nanocarrier materials and the antifibrotic activity of drug-loaded nanoparticles, respectively. In vivo, the bleomycin-induced rat models of pulmonary fibrosis were established to study the efficacy of chitosan nanoparticles.Results In vitro experiments indicated that the drug-loaded chitosan nanoparticles exhibited good stability and low cytotoxicity. In vivo pharmacodynamic studies revealed that, compared with oral administration of Cur or NDNB alone, the pulmonary delivery of Cur/CS-VES NPs and NDNB/CS-PGA NPs effectively inhibited the progression of pulmonary fibrosis, improved lung function, reduced levels of inflammatory factors, and mitigated pathological lesions in the lungs. These findings suggest that chitosan-based nano-particles have promising potential as pulmonary inhalation agents for the treatment of pulmonary fibrosis.Conclusion These findings highlight the great potential of chitosan-based nanoparticles as a therapeutic strategy for treating IPF and related pulmonary fibrosis with pulmonary delivery pathways.
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JOURNAL OF LIPOSOME RESEARCH
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2025
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IF 4.3
Amna Naz,Sadia Haider,Malik Ihsan Ullah Khan,Rabia Khokhar,Mavra Rubab,Muhammad Farooq,Attia Afzal,Muhammad Sarfraz
This study addresses the limitations of traditional cancer therapies—such as high toxicity and non-selectivity—by developing a novel nanoparticulate system co-loaded with plant-derived compounds, apigenin (APG) and oleanolic acid (OA). These naturally occurring phytochemicals are known for their anticancer properties but face clinical challenges due to poor solubility and limited efficacy. The Apigenin and Oleanolic Acid Nanoparticulate System (AONS) was refined and optimized using the Box-Behnken statistical design approach, resulting in nanoparticles with a mean diameter of 169 nm and size homogeneity. A validated HPLC technique was employed to simultaneously quantify both apigenin and oleanolic acid in the developed formulation as well as in various biological matrices. In vitro drug release was enhanced at acidic pH (5.5), mimicking the tumor microenvironment. AONS showed strong physicochemical stability under refrigerated storage. Cytotoxicity tests on HepG2, MDA-MB-231, and U87 glioma cells demonstrated significantly improved anticancer activity compared to control, free drugs, or individual nanoformulations. Cellular uptake studies confirmed efficient internalization in U87 cells, and ELISA results indicated apoptosis via activation of the p53 pathway. Biodistribution analysis revealed prolonged systemic drug retention with AONS (up to 72 hours), surpassing the short circulation time of free drugs. Notably, LC-MS data confirmed that the nanoparticle system could cross the blood-brain barrier, highlighting its therapeutic potential for treating brain cancers.
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CHEMICAL ENGINEERING COMMUNICATIONS
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2025
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IF 2
Fan Pan,Lijiang Tian,Fulong Chen,Jie Zhang
The photocatalytic efficiency of titanium dioxide(TiO2) is easy to restrict by rapid recombination of carriers, narrow spectrum response range, and low specific surface area. Constructing heterojunctions has been widely acknowledged as a viable strategy to enhance the photocatalytic performance of TiO2. Here, TiO2@MIL-101(Cr) heterojunction was synthesized via the in-situ method and applied to adsorbing and photocatalytic degrading of gaseous benzene. The findings demonstrate 40TM exhibited the best adsorption(1157.03 μgC6H6/(g·h)) and photocatalytic(817.80 μgC6H6/(g·h)) performance, which were 2.05 and 5.21 times of TiO2, respectively. The enhancement of adsorption performance probably resulted from the higher specific surface area(637.33 m2/g) and the micro-mesoporous structure. The excellent photocatalytic performance might stem from the extended wavelength response range(400–700 nm) and the Z-scheme heterojunction formation. The possible mechanism is that electrons in MIL-101(Cr) and holes in TiO2 could participate in redox reactions to generate radicals, with superoxide radicals(∙O2−) and hydroxyl radicals(∙OH) being identified as the primary active species for benzene degradation. Overall, this investigation offers a valuable reference for the application of heterojunction catalysts in the field of adsorption-photocatalytic degradation of volatile organic compounds (VOCs).
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INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
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2025
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IF 2.5
Huiwen Fang,Yuxuan Wang,Yongqing Bai,Pin He,Yong Yang,Fengqin Tu,Shu Wang,Guifeng Xu,Xiaoting Zhou,Weixuan Tang,Zhe Chen,Xiaoming Ma
To establish a method for rapid screening of phthalates (PAEs) in edible oils by surface enhanced Raman spectroscopy (SERS). PAEs was reduced to terephthalic dihydrazide using hydrazine hydrate to enhance its hydrophilicity, and then combined with Au nanoparticles (AuNPs) to produce Raman spectroscopy enhancement effect, which was determined. The reliability of the method was confirmed by comparing with SERS spectra of hydrophilic modification product derived from PAEs and terephthalic dihydrazide standard solutions. The optimum reaction conditions of hydrophilic modification and Raman spectroscopy were further explored, and the reaction temperature, time, amount of hydrazine hydrate and concentration of coagulant were determined. In the range of 1–100 µg/mL, the characteristic peak intensity at 1375 cm−1 showed a linear relationship with the concentration of PAEs, the correlation coefficient (r) was 0.999, and the limit of detection was 0.1 µg/mL. The method was used for rapid screening of PAEs in edible oils samples, with PAEs concentration of 10, 50 and 100 mg/kg. The screening results were positive, achieving a detection rate of 100%. Thus, it can serve as a new method for daily production quality control and emergency detection of edible oil products.
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Journal of Sustainable Cement-Based Materials
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2025
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IF 4.2
Deepak Patwa,Zihan Sang,Shuxiang Zhang,Kai Yao,Zhengzhi Liu,Lianhao Liu,Haoqiang Cao,Zhanyong Yao
Cement is commonly used to mitigate local scouring around offshore foundations; however, it suffers from poor durability in harsh marine environments and contributes to carbon emissions. Therefore, this study aims to develop sustainable alkali-activated-soil-fly ash-GGBS (AASFG) slurry for scour protection. Slurry was formulated using silty soil with 20%, 30%, and 40% fly ash and GGBS (1:1 ratio), activated with sodium silicate and NaOH at varying modulus ratios (1.0, 1.2, and 1.4) and Na2O contents (6%, 8%, and 10%). Performance was evaluated through fluidity, turbidity, washout resistance, and unconfined compressive strength (UCS). Results showed that slurry behavior is governed by the interplay of modulus, Na2O, and binder content. While the mix S60F20G20M1.2N10 achieved the highest UCS (12.88 MPa in air, 10.29 MPa underwater), it had poor washout resistance. The mix S70F15G15M1.2N8 exhibited balanced performance. Co-existence of ettringite, N-A-S-H, C-A-S-H, and C-S-H gels contributed to strength. AASFG slurry shows promise as an eco-friendly anti-scour.
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JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2025
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IF 3.6
Xiaoguang Liu,Qi Lin,Yi Zhong,Yanling Li,Ji’e Zhang,Yuhua Zhan,Yijia Sun,Ruixia Hou
Catheter-associated urinary tract infections (CAUTIs), the most prevalent hospital-acquired infections globally, remain unresolved despite the development of antimicrobial catheters incorporating silver or antibiotics. To address this challenge, a quaternized chitosan (HTCC)-functionalized catheter was developed through oxygen plasma activation of polyvinyl chloride (PVC) surfaces, followed by polydopamine (PDA) coating and HTCC grafting. This process improves the hydrophilicity of the PVC surface, which is beneficial for reducing urethral mucosal damage in patients, inhibiting the formation of bacterial biofilms, reducing friction and improving patient comfort. This approach eliminated the need for potentially toxic silver nanoparticles and the issue of antibiotic resistance while enhancing surface hydrophilicity. The modified catheter demonstrated superior antibiofilm and antimicrobial efficacy against key uropathogens, including Staphylococcus aureus and Escherichia coli, compared to commercial PVP-urea coated PVC catheters. With its combined advantages in surface wettability, antimicrobial performance, and biocompatibility, this HTCC-based design presents a promising solution for CAUTI prevention and establishes a new paradigm for medical device coatings.
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International Journal of Nanomedicine
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2025
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IF 6.5
Qingyan Li,Weilin Zheng,Jingge Cheng,Bo Li,Yutian Lei,Huilong Guo,Youshan Xv,Jiaming Huang,Xiaoxing Liao
Introduction Diabetic wounds represent a growing clinical challenge worldwide, characterized by persistent immune dysregulation and excessive inflammation that lead to impaired healing and chronic progression.Methods To address this, we developed a composite nanosystem, termed Ru@ACEI, composed of ruthenium-incorporated hollow mesoporous silica nanoparticles loaded with angiotensin-converting enzyme inhibitors (ACEIs).Results The Ru@ACEI nanoparticles exhibit dual enzyme-mimetic activities (superoxide dismutase and catalase), effectively scavenging excess reactive oxygen species (ROS). This activity reduces cellular apoptosis and promotes endothelial cell proliferation. Following cellular uptake, Ru@ACEI catalyzes the decomposition of peroxides into water and oxygen, thereby suppressing the NLRP3/Caspase-3/Caspase-9 apoptosis pathway. The consequent improvement in endothelial cell survival helps reverse local hyperinflammation in diabetic wounds.Conclusion Collectively, these findings demonstrate that the Ru@ACEI nanosystem accelerates diabetic wound healing by mitigating the inflammatory microenvironment and downregulating the expression of pro-inflammatory factors, offering a promising therapeutic strategy for managing chronic diabetic wounds.
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Journal of Pain Research
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2025
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IF 2.5
Min Song,Weichang Han,Jingyi Li,Gaoyi Wu,Haibo Yu,Qing Yuan,Jiani Yu
Background Knee osteoarthritis (KOA) is indeed a major global health issue, characterized as the most common form of osteoarthritis. It affects millions of people worldwide, leading to joint pain, stiffness, and functional limitations. As life expectancy increases and populations age, KOA’s impact on quality of life and public health systems becomes more pronounced. Our objective was to evaluate pain-related behaviors, tibial cartilage pathology, and inflammatory factor expression levels in rats following different doses and administration times of monosodium iodoacetate (MIA) to explore its effects on KOA.Methods The rats were allocated into two groups: an experimental group and a control group. In the experimental group, MIA was administered as a single intra-articular injection into the left knee joint to induce KOA. The dosage varied between 0.5 mg and 2.0 mg. Following the injection, assessments were conducted on days 3, 5, 7, 14, 21, and 28 to evaluate knee circumference, pain-related behavior, tibial cartilage pathology, and the expression levels of IL-1β and IL-10.Results The knee joint diameters expanded in a dose- and time-dependent manner, paralleled by corresponding reductions in MIA-induced paw withdrawal threshold (PWT) and weight-bearing distribution (WBD), both of which followed similar dose- and time-dependent patterns. Compared with controls, MIA-treated rats exhibited significantly heightened defensive behaviors (eg, paw licking, retraction), confirming successful inflammatory pain induction. Pain intensity analysis revealed lower pain scores in the 0.5 and 1.0 mg MIA groups relative to 1.5 and 2.0 mg groups across the study. Pain severity escalated sharply from day 0 to 7, stabilized until day 14, and peaked again at day 28. Histologically, the 1.5 and 2.0 mg MIA groups demonstrated early-stage KOA pathology (days 5–20), characterized by chondrocyte cloning and matrix disorganization, followed by mid-stage features (days 21–27) including localized cartilage defects, surface irregularities, hypocellularity, and vascular infiltration. By day 28, late-stage KOA hallmarks emerged, such as widespread cartilage degeneration, subchondral bone exposure, and peripheral osteophytes. These histological findings aligned with behavioral pain outcomes and ELISA results, collectively illustrating synchronized progression of inflammatory and structural pathology across all assays.Conclusion The severity of pain, the extent of articular cartilage degeneration, and the level of inflammatory response following intra-articular MIA injection progressively worsened in a dose- and time-dependent fashion. In the MIA group, early-stage KOA cartilage pathology was observed between days 5 to 20 post-injection. By day 21, cartilage lesions progressed to mid-stage KOA cartilage, and by day 28, they advanced to late-stage KOA cartilage. The pain trajectory corresponded with the pathological features of MIA-induced KOA, offering valuable insights into optimal dosing and timing for targeted KOA pain management interventions.
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