ACS Applied Nano Materials
·
2025
·
IF 5.5
Jiaxin Li,Junhui Liang,Xin Yao,Hongming Liu,Yuhui Du,Huayu Chen,Hangning Chen,Chenhao Du,Liuqi Wang,Yincheng Li,Yuexiang Huang,Da Chen
The development of low-temperature, nonprecious metal thermocatalysts for ammonia decomposition holds significant promise for advancing the green hydrogen industry. LaNiO3 catalysts, with their perovskite structure (ABX3), are notable for enabling in situ growth of active metal Ni on reduced oxide supports during ammonia decomposition reactions (ADRs). However, unintentional in situ growth can lead to uncontrolled reactions and metal particle agglomeration. To address this, we employed a straightforward high-temperature and pressure hydrogenation pretreatment process to enhance the interaction between the active metal and the support, thereby suppressing the agglomeration of the active metal during the ADR process. Our results indicate that the hydrogenation pretreatment catalyst exhibits finer Ni metal nanoparticles, with an average size of approximately 8 nm. Under a gas hourly space velocity (GHSV) of 18,000 mL gcat–1 h–1 and at 550 °C, the NH3 conversion efficiency reaches 90%, which exhibited excellent stability over a period of 100 h. Additionally, we utilized TEM, XPS, EPR, NH3-TPD, and H2-TPR techniques to elucidate the intrinsic mechanisms related to the enhanced catalytic activity. This study addresses the issue of active metal nanoparticle agglomeration through hydrogenation pretreatment.
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Nature Electronics
·
2024
·
IF 33.7
Liu Dingyao,Tian Xinyu,Bai Jing,Wang Shaocong,Dai Shilei,Wang Yan,Wang Zhongrui,Zhang Shiming
Organic electrochemical transistors could be used in in-sensor computing and wearable healthcare applications. However, they lack the conformity and stretchability needed to minimize mechanical mismatch between the devices and human body, are challenging to fabricate at a scale with small feature sizes and high density, and require miniaturized readout systems for practical on-body applications. Here we report a wearable in-sensor computing platform based on stretchable organic electrochemical transistor arrays. The platform offers more than 50% stretchability by using an adhesive supramolecular buffer layer during fabrication that improves robustness at interfaces under strain. We fabricate stretchable transistor arrays with feature sizes down to 100 μm using a high-resolution six-channel inkjet printing system. We also develop a coin-sized data readout system for biosignal acquisition. We show that our coin-sized, smartwatch-compatible electronic module can provide wearable in-sensor edge computing.
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ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Junjie Wang,Jingwei Yu,Hongbo Wei,An Wang,Zishuo Hou,Moses Kumi,Xinge Wang,Tengjiao Wang,Peng Li,Wei Huang
Traumatic brain injury (TBI)-induced post-traumatic epilepsy (PTE) is a serious brain disease that causes the loss of motor functions, cognitive impairments, and even death. Real-time and long-term electrophysiological signal monitoring has significant implication for the treatment of patient with TBI. Brain–computer interfaces (BCIs) utilizing flexible electrodes enable accurate epilepsy identification by electrocorticography (ECoG) signal monitoring. In this study, a customized flexible osteoid electrode is developed, which contributes to demands and personal differentiation among patients with TBI. The end product of osteoid electrode after full osseointegration will be a stable and firmly integrated structure within the bone tissue, providing a secure platform for continuous electrophysiological signal monitoring. The flexibility and conductivity of the osteoid electrode enables high-quality and long-term epilepsy monitoring. Biocompatibility of the osteoid electrode is also demonstrated by in vitro cell experiments. Simultaneously, the porous osteoid electrode also exhibits osseointegration ability based on potential long-term ECoG signal monitoring, which suggests its potential for the comprehensive treatment of TBI patients. This work not only introduces a potential therapeutic scaffold for TBI-related diseases, but also provides promising techniques for clinical ECoG monitoring in patients with TBI.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Haixue Zhao,Jinghan Peng,Zidan Chen,Yingtang Zhou,Ming Xu,Haibo Zhang,Xue Zhao
The development of high performance and stable heterogeneous catalysts is conducive to promoting the advanced oxidation process (AOPs) to promote the degradation of organic pollutants efficiently, low-cost and environmentally friendly. Here nitrogen-doped hollow carbon spheres (NHCSs) and rigid organic molecule were used to create space confinement and complexation confinement conditions, respectively, and an advanced single-atom catalyst capable of strongly activating peroxymonosulfate (PMS) to degrade organic pollutants was finally constructed. The AOPs system driven by CoNC/NHCSs (20 mg) combined with PMS (20 mg) can degrade nearly 100 % of 20 mg/L (100 mL) bisphenol A (BPA, a microplastic) pollutant within 30 min, and the mineralization rate is up to 70.5 %. Face the complex water environment, such as sewage containing coexisting anions and cations, or acidic or alkaline sewage, the CoNC/NHCSs/PMS system still has high catalytic stability, and universality for other organic pollutants. The filter column with CoNC/NHCSs as the core also realizes the continuous purification of organic pollutants, which shortens the distance between laboratory research and practical application. Radical quenching and electron paramagnetic resonance techniques confirmed that CoNC/NHCSs activated PMS to SO 4 ·− , ·OH, and 1 O 2 , and these reactive oxygen species combined to eliminate organic pollutants. Density functional theory (DFT) calculations jointly confirm that the strong activation of PMS by CoNC/NHCSs is the key to achieving efficient degradation of organic pollutants, and the activity of CoNC/NHCSs is derived from high exposure rate of active sites and curvature effect caused by structural bending.
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Advanced Science
·
2025
·
IF 14.1
Jiaqiang Xiong,Juyuan Huang,Hanxiao Xu,Qiuji Wu,Jiahui Zhao,Yurou Chen,Guanlan Fan,Haotong Guan,Rourou Xiao,Zhaojin He,Siqi Wu,Wenliang Ouyang,Shixuan Wang,Lu Zhang,Peng Xia,Wei Zhang,Meng Wu
CpG oligodeoxynucleotides (CpG), as an immunoadjuvant, can facilitate the transformation of tumor-associated macrophages (TAMs)into tumoricidal M1 macrophages. However, the accumulation of free CpG in tumor tissues remains a substantial challenge. To address this, a nanovaccine (PLGA-CpG@ID8-M) is engineered by encapsulating CpG within PLGA using ID8 ovarian cancer cell membranes (ID8-M). This nanovaccine demonstrates remarkable efficacy in reprogramming TAMs in ovarian cancer and significantly extends survival in ID8-bearing mice. Notably, these findings indicate that the nanovaccine can also mitigate chemotherapy-induced immunosuppression by increasing the proportion of M1-like TAMs and reducing the expression of CD47 on tumor cells, thereby achieving a synergistic effect in tumor immunotherapy. Mechanistically, through transcriptome sequencing (RNA-seq), single-cell RNA sequencing (scRNA-seq), and mass spectrometry-based proteomics, it is elucidated that the nanovaccine enhances the expression of Gbp2 and promotes the recruitment of Pin1, which activates the NFκB signaling pathway, leading to the M1 polarization of TAMs. Furthermore, macrophages with elevated Gbp2 expression significantly inhibit tumor growth in both ID8 ovarian cancer and 4T1 breast cancer models. Conversely, targeting Gbp2 diminishes the antitumor efficacy of the nanovaccine in vivo. This study offers an innovative approach to immunotherapy and elucidates a novel mechanism (Gbp2-Pin1-NFκB pathway) for remodeling TAMs.
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PubMed
高影响因子
Journal of Materials Chemistry C
·
2024
·
IF 5.7
Xin Huang,Tingting Zhang,Haomiao Zhang,Jiahui Yang,Tingting Cui,Rui Cheng,Jian Yu
In recent years, the rapid advancement of carbon dots (CDs) has established them as highly promising candidates in the field of fluorescent nanomaterials. Microfluidic technology, known for its efficiency in nanomaterial synthesis, has encountered significant challenges in the production of CDs due to insufficient fluid driving force, a consequence of the high-pressure conditions generated in microfluidic channels during high-temperature reactions. This limitation has significantly constrained the application of microfluidic technology in synthesis of CDs. To address this issue, this study developed a controllable, high-pressure gas driven microfluidic platform, enabling the large-scale production of CDs with multicolor fluorescence emission. By precisely regulating the pressure in feedstock tank and the opening of control valves, continuous and stable fluid flow and reactions were maintained in high-temperature heated channels, even when using low-boiling-point solvents. Adjustments in reaction temperature and precursor selection facilitated the large-scale synthesis of CDs emitting blue, green, yellow, and red fluorescence (B-CDs, G-CDs, Y-CDs and R-CDs). Furthermore, the excellent biocompatibility and low toxicity of the G-CDs enabled the successful application in cellular imaging. This work provides a novel solution to the challenge of insufficient fluid driving force in microfluidic synthesis of CDs, and it is expected to promote further advancements in the use of microfluidic technology for large-scale production functional nanomaterial.
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SURFACE & COATINGS TECHNOLOGY
·
2024
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IF 5.3
Xing Yan,Minjie Li,Dongjie Liao,Jianquan Jing,Jiao Chen,Jiechao Wang,Mianji Qiu,Chuanhao Xu,Jingyu Wang,Chongwei An
Surface coating is an important method to solve the poor stability of aluminum hydride (AlH 3 ). To overcome the difficulty of uneven coating of fluorine-containing polymers on the surface of AlH 3 , this study utilizes the adhesion properties of polydopamine (PDA) to establish a bridge between the oxide layer of AlH 3 (Al 2 O 3 ) and polyvinylidene fluoride (PVDF), so that Polyvinylidene fluoride (PVDF) was uniformly coated on the AlH 3 surface, and a dual-core shell structure AlH 3 @PDA@PVDF composite was successfully prepared. Molecular dynamics simulations reveal significantly higher binding energy per unit area for γ-Al 2 O 3 @PDA/PVDF (1.2270 Kcal·mol −1· Å −2 ) compared to γ-Al 2 O 3 /PVDF (0.6644 Kcal·mol −1· Å −2 ), affirming that PDA can effectively enhance the interfacial interaction between AlH 3 and PVDF. The morphology characterization and performance testing of raw AlH 3 and AlH 3 @PDA@PVDF composite were carried out through SEM, XPS , FT-IR, DSC , VST, etc. The results indicate that through the interface modification of AlH 3 by PDA, PVDF with a hydrophobic surface can be evenly coated on the surface of AlH 3 , causing the water contact angle (WCA) of the AlH 3 @PDA@PVDF composite to increase from 41° for the raw AlH 3 to 124°. Furthermore, the total decomposition time of the AlH 3 @PDA@PVDF composite (2326 min) is improved by 1.8 times than that of the raw sample (1277 min), and its apparent activation energy (117.75 kJ·mol −1 ) was also higher than that of the raw sample (99.88 kJ·mol −1 ), indicating that coating with PDA and PVDF can improve the stability of AlH 3 . Ignition experiments demonstrate that the AlH 3 @PDA@PVDF composite has superior ignition reaction performance compared with the raw AlH 3 . Especially, adding a small amount of AlH 3 @PDA@PVDF composite can also significantly catalyze the thermal decomposition process of ammonium perchlorate (AP), reducing its high-temperature decomposition temperature from 405.37 °C to 352.20 °C.
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Environmental Science-Nano
·
2024
·
IF 5.8
Yuxuan Shao,Dan You,Yuqi Wan,Zhiquan Pan,Qingrong Cheng
A novel hyper-crosslinked triazine-based COF (HCTF-2) photocatalyst was prepared by a simple molecular expansion method. Compared with CTF-2, HCTF-2 showed excellent photocatalytic performance under visible light irradiation. The photodegradation efficiency of HCTF-2 for some pollutants (20 ppm tetracycline (TC), 30 ppm rhodamine B (RhB), 20 ppm levofloxacin hydrochloride (LEF) and 20 ppm methylene blue (MB)) can reach more than 99% in a short time. Meanwhile, HCTF-2 had a stronger hydrogen production rate (2728.61 μmol h−1 g−1), which was 5.11 times higher than that of CTF-2 (534.12 μmol h−1 g−1). Molecular oxygen activation experiments confirmed that HCTF-2 exhibited strong oxidation capacity for 3,3′,5,5′-tetramethylbenzidine (TMB), and superoxide radical and hydrogen peroxide generation ability. The photodegradation active species were identified through free radical trapping experiments and ESR. Moreover, the possible degradation pathways of LEF were analyzed by liquid chromatography-mass spectrometry (LC-MS). The enhanced photocatalytic ability of HCTF-2 was attributed to the strong absorption of visible light and the porous braided structure leading to a larger specific surface area with higher carrier separation efficiency. This research provided a strategy for the development of specially structured COFs for photocatalytic applications and more efficient improvement of photocatalytic efficiency.
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JOURNAL OF POLYMER RESEARCH
·
2024
·Vol. 31
·期 10
·1-15
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IF 2.6
Meng Qi,Xu Hongxing,Li Yiran,Liu Fei,Shao Huarong,Ling Peixue,Wu Shaohua
The use of electrospun nanofibers to create a supportive scaffold for cell growth and tissue development has attracted intensive interest in the field of tissue engineering. In this study, a conjugated electrospinning system was designed and employed to fabricate a series of different polycaprolactone (PCL) scaffolds simultaneously containing both of microfibers and nanofibers. SEM images conformed the successful formation of micro-/nano- fibers in one scaffold by adjusting the polymeric concentrations. The PCL concentration was found to have dramatic effects on the diameter of as-generated fibers, and the mean diameter and crystallinity of electrospun PCL fibers decreased with the decreasing of PCL concentration, resulting in much lower mechanical properties. Compared with the pure PCL microfiber-constructed scaffold, the PCL micro-/nano- fiber scaffolds exhibited obviously decreased mean pore size, increased porosity. Interestingly, the PCL micro-/nano- fiber scaffolds were found to exhibit significantly increased Young’s modulus and ultimate stress than both of PCL nanofiber scaffold and PCL microfiber scaffold. In vitro cell characterization results indicated that the introduction of nanoscale fibers significantly enhanced cell adhesion, and proliferation of PCL micro-/nano- fiber scaffolds. Moreover, this enhancement became more pronounced as the average diameter of the nanoscale fibers decreased. Overall, our present study provides an effective strategy for generating PCL micro-/nano- fiber scaffolds with more appropriate structure and properties, which show great potential for tissue engineering application.
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Regenerative Biomaterials
·
2024
·
IF 5.6
Wu Sui,Dong Ruichen,Xie Yinhong,Chen Wenhao,Liu Wei,Weng Yajun
During the implantation process of cardiovascular implants, vascular damage caused by inflammation occurs, and the inflammatory process is accompanied by oxidative stress. Currently, carbon monoxide (CO) has been demonstrated to exhibit various biological effects including vasodilatation, antithrombotic, anti-inflammatory, apoptosis-inducing, and antiproliferative properties. In this study hemoglobin/epigallocatechin-3-gallate (EGCG) core-shell nanoparticle containing coating on stainless steel was prepared for CO loading and inflammation modulation. Inspired by strong coordination ability with CO, hemoglobin nanoparticle was first prepared and encapsulated into EGCG metal-phenolic networks. A polydopamine linking layer was then coated on 316 stainless steel, and the hemoglobin/EGCG nanoparticles was loaded with the subsequent polydopamine deposition. It showed that the maximum release amount of CO by the coating was 17.0 nmol/cm2 in 48 hours. In vitro evaluations conducted in a simulated inflammatory environment revealed that the coating, which released CO from hemoglobin/EGCG nanoparticles, effectively mitigated the LPS-induced inflammatory response in macrophages. Specifically, it decreased the expression of TNF-α, increased the expression of IL-10, suppressed the polarization of macrophages towards the M1 phenotype, and reduced intracellular reactive oxygen species (ROS). Furthermore, under simulated oxidative stress conditions, the coating decreased the apoptosis of endothelial cells induced by oxidative stress and downregulated intracellular ROS levels. In vivo implantation results further confirmed that the coating, with its hemoglobin/EGCG nanoparticles and CO release capabilities, reduced macrophage-mediated inflammatory responses and modulated the polarization phenotype of macrophages.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Ciyang Zhang,Tianxiang Hang,Ziwen Shi,Ming Yang,Keren Lu,Haiyan Jing,Mingzhu Xia,Qingli Hao,Xifeng Xia,Wu Lei
Corrosion is one of the major problems affecting the durability and structural integrity of metallic materials, and the addition of various functional factors to epoxy coatings to impart multifunctional properties has been widely used. However, systems that physically mix multiple functional ingredients to achieve a multifunctional coating can lead to inter-ingredient competition, destabilizing the overall properties. This work developed a smart corrosion inhibition system based on ZIF8 encapsulated 1-Aminostyrene derivative (ZIF8@L1) to address these challenges. When corrosion occurs, the change in pH at the corrosion site disrupts the ZIF8 structure, releasing L1, which forms a protective film on the iron surface, effectively slowing down steel corrosion. As corrosion progresses, L1 coordinates with Fe 3+ , resulting in the cleavage of the C-N bond within the Schiff base and the disappearance of the intramolecular charge transfer (ICT) process, leading to fluorescence enhancement, thus enabling real-time visualization of the corrosion area. Experiments have shown that the decomposition products of L1 also have a certain corrosion inhibition effect on iron. To further elucidate the corrosion inhibition mechanism, this study provides an in-depth analysis of the corrosion inhibition effects of the organic small molecules discussed in this paper utilizing various characterization tools and first-principles computational methods. This work proposes an intelligent system that integrates corrosion inhibition, self-healing, and fluorescence tracing, providing a novel perspective for multifunctional intelligent coatings and opening up new pathways for multifunctional composite coatings, which are suitable for a wide range of applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Qingru Yang,Qinghong Shi,Xiaoyan Dong,Linling Yu,Yan Sun
Hydrolysis of organophosphates (OPs) with organophosphate hydrolase (OPH) provides a green approach to degrading OPs, but the success of enzymatic OPs degradation relies on the availability of high-efficiency OPH. Herein, we report a simple but effective way to constructing high-performance OPH preparations based on the in situ encapsulation of hexahistidine-tagged OPH (H 6 -OPH) into cobaltous zeolitic imidazolate framework (ZIF-67) via biomineralization. ZIF-8 made of the same organic ligand but a different metal ion (Zn 2+ ) was used for comparison. It was found that the H 6 -tag domain did not affect the catalytic properties of OPH in the absence of Co 2+ , but boosted the Co 2+ -activation effect on the H 6 -OPH catalytic activity by two-fold. Furthermore, H 6 -OPH@ZIF-67 retained the highly boosted activity, while H 6 -OPH@ZIF-8 and OPH@ZIF-67/ZIF-8 lost most of the activities. Extensive analysis revealed that the H 6 -tag promoted the Co 2+ -induced OPH conformation transition and locked the activated conformation in ZIF-67. Notably, H 6 -OPH@ZIF-67 not only achieved an activity recovery as high as 348 % and a 321 % increased catalytic efficiency ( k cat / K m ) over free OPH, but also exhibited greatly improved stability and reusability. The findings underscore the high efficiency of fabricating high-performance OPH preparations via polyhistidine-tag fusion, Co 2+ activation and locking by the cobalt-organic framework.
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