Construction of succinoglycan riclin-Pt (IV) conjugates for carrying resveratrol: a potential tool for biomedical applications

Succinoglycan riclin (RIC), a natural polysaccharide with diverse biological activities, was employed as a drug carrier to construct a novel nanoplatform. Polysaccharide-Pt(IV) conjugates were synthesized via esterification between the hydroxyl groups of RIC and a Pt(IV) prodrug, which was subsequently loaded with resveratrol (RES) to form the RES@RIC-Pt(IV) nanoplatform. The successful synthesis and physical properties of the complex were confirmed through multiple characterization techniques. Pt(IV) was significantly bonded to the polysaccharide chain. The drug loading capacities for platinum and RES were quantified using ICP-OES and UV–Vis spectrophotometry, respectively. The percentage of Pt content in RIC-Pt (IV) conjugates can be calculated as 11.71%. In vitro cytotoxicity assays revealed that the RES@RIC-Pt(IV) platform exhibited significantly enhanced toxicity against HepG2 and LO2 cancer cell lines compared to individual small-molecule drugs. These results demonstrate that this multi-drug delivery system achieves a potent synergistic anticancer effect, highlighting its potential for improved cancer therapy. Graphical abstract