Integrative Network Pharmacology and Transcriptomics Reveal the Mechanism of XuanShi Choudong Recipe in the Treatment of Tic Disorder

Using an integrated strategy of network pharmacology and transcriptomics, this study elucidates the therapeutic mechanism of XuanShi Choudong Recipe (CDR) against tic disorder (TD). CDR dose‐dependently alleviates apomorphine‐induced tic‐like stereotypy and hyperlocomotion in rats, restores striatal neurotransmitter homeostasis, and attenuates oxidative stress injury and neuronal apoptosis. Mechanistically, the neuroprotective effect of CDR is closely associated with activation of the PI3K/AKT/Bcl‐2 signaling pathway, providing preliminary experimental evidence for its clinical application in TD.