SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Boyuan Li,Jiantao Shi,Chiyuan Wei,Wenjie Zhao,Yuanqiang Sun,Ningning Wang,Lingbo Qu,Zhaohui Li
Excessive intake of hypochlorite (ClO - ) poses significant health risks, demanding rapid and reliable detection methods for food safety. Herein, we developed an intelligent dual-mode visual sensing system that strategically integrates upconversion nanoparticles (UCNPs) with a rationally designed meso-phosphino-substituted BODIPY probe (TMBP) for rapid ratiometric colorimetric and upconversion luminescence (UCL) detection of ClO - . The reaction of ClO - with the diphenylphosphine group of TMBP yields an electron-withdrawing phosphine oxide, a transformation confirmed by mass spectrometry and density functional theory (DFT) calculations. This transformation induces an obvious increase in the A 600 /A 545 ratio and a remarkable color transformation from pink to blue. Under 980 nm excitation, the upconversion luminescence concurrently exhibits an increase in the I 548 /I 664 intensity ratio and a distinct color transition from red to green, which is primarily attributed to an inner filter effect between UCNPs and ClO - -reactive probes. This dual-ratiometric signal readout provides built-in self-validation through mutual cross-checking, substantially enhancing detection reliability and reducing the risk of false positives. The system responds within 5 s and is suitable for diverse detection scenarios. Furthermore, a portable 3D-printed device integrated with a smartphone and a freely available color-analysis application was developed, enabling practical on-site quantification with results comparable to laboratory spectrophotometry. The system has been successfully applied to detect ClO - in food samples, demonstrating high accuracy via spike-recovery tests. This work not only presents a sensitive and rapid ClO - sensor but also bridges advanced nanotechnology with practical, user-friendly applications, offering a robust tool for food safety monitoring.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
·
IF 9.1
Zhanpeng Wang,Ruinian Xu,Ning Liu,Chengna Dai,Biaohua Chen
During the glycolysis of waste polyester textiles for the recovery of bis(2-hydroxyethyl terephthalate) (BHET), residual color impurities and Zn 2+ in the product significantly restrict the high-value application of recycled PET. In this study, deep eutectic solvents (DESs) were employed as extractants to simultaneously remove dyes and metal ions from waste PET glycolysis solution. A DES composed of decanoic acid and oleic acid was identified as effective, achieving a decolorization efficiency of 90.5%, a BHET loss of 5.9%, and a Zn 2+ removal ratio of 42.3% in a single extraction from a model system dyed with Disperse Blue 56 under optimal operating conditions. Quantum chemical calculations and spectroscopic characterization revealed that dye extraction occurs mainly through a physical process dominated by van der Waals interactions, while Zn 2+ removal follows an ion-exchange mechanism, resulting in the formation of a Zn 2 + - [DecA] 2 − - OleA complex in the oil phase. The extraction of Zn 2+ was found to be thermodynamically limited due to the high stability of the tetradentate complex formed between BHET and Zn 2+ . This work aims to propose a practical strategy for impurity removal in the closed-loop recycling of colored PET textiles.
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CHINESE JOURNAL OF CATALYSIS
·
2026
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IF 17.2
Heng Zhou,Longfei Hong,Yan Zhang,Yuyue Zhou,Sheng Chu,Huiyan Zhang,Hui Li,Tianyi Ma,Heng Zhang
Harnessing solar energy as a power source for sustainable fuel production from biomass waste presents an effective solution to energy and environmental challenges. However, efficient utilization of low-energy near-infrared (NIR) light (representing ~50% of solar irradiance) continues a critical bottleneck especially for non-edible oils valorization. Here, we report a cellulose-derived sulfonated hydrochar (PC-SO 3 H-1) utilizing the full solar spectrum for highly efficient biodiesel production, achieving a remarkable biodiesel yield of 98.29% within only 30 min, which far exceeds the theoretical limit. Favorable NIR absorption of narrow bandgap PC-SO 3 H-1 combined with substrate adsorption capacity enhanced by -SO 3 H functionalization overcomes thermodynamic equilibrium limitations. The optimized charge transfer dynamics accelerate the interfacial localized photothermal effect, driving the esterification reaction forward while minimizing heat loss and significantly enhancing the utilization of NIR photons. Density functional theory calculations demonstrate the formation of crucial intermediate ester carbonyl groups (C=O), with PC-SO 3 H-1 effectively reducing the activation energy barrier associated with the rate-limiting process. This sustainable noble metal-free photothermal catalytic system of high-efficiency overcomes the reliance of traditional photocatalysis on high-energy photons, offering novel insights into the full spectrum solar-driven production of green and renewable biofuels.
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CARBOHYDRATE POLYMERS
·
2026
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IF 13.2
Haoyang Yuan,Ningsen Zhang,Yuyu Gao,Ning Zhang,Yu Zhang,Tian Yin,Haibing He,Xing Tang,Peifu Xiao,Jingxin Gou,Xinyu Fan
Repeated intramuscular administration of progesterone (PRG) oily injections often causes macrophage-mediated injection-site reactions and pain, limiting patient compliance during long-term therapy. Herein, a PRG-loaded hydroxyethyl starch-coated semi-solid lipid microparticle system (HES-SLM) was developed for low-irritant sustained intramuscular delivery. Oleic acid-grafted HES was synthesized as an emulsifier, and HES-SLM was prepared by melt emulsification using glyceryl monostearate/medium-chain triglycerides as the lipid core, with PEG-SLM as a control. HES-SLM exhibited a uniform spherical morphology, a D 50 of 34.36 ± 0.42 μm, low burst release within 2 h (4.17 ± 0.98%), and sustained release for 13 days. Compared with PEG-SLM, HES-SLM significantly reduced macrophage infiltration, inflammatory cytokine expression, collagen deposition, and profibrotic responses at the injection site, thereby improving the local release microenvironment and facilitating PRG transport into systemic circulation. Consequently, HES-SLM markedly increased PRG exposure, with an AUC 0–t of 3649.113 ± 1066.590 ng·mL −1 ·h versus 1751.285 ± 357.668 ng·mL −1 ·h for PEG-SLM. In immature female rats, HES-SLM also achieved efficacy comparable to marketed PRG oily injection and reduced inflammatory factors and Nav1.8 expression, indicating reduced injection-site pain. This study provides a surface-modified microparticle strategy for sustained, low-irritant intramuscular PRG delivery with reduced dosing frequency.
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Cell Reports Medicine
·
2026
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IF 14
Xiaomeng Dai,Chunyu Lai,Libing Hong,Yuzhi Jin,Jinlin Cheng,Haimeng Yan,Xuqi Sun,Bin Li,Chuan Liu,Hangyu Zhang,Yanwei Lu,Haibo Zhang,Danyang Wang,Peng Zhao,Yu Shi,Weijia Fang,Shan Xin,Xia Yu,Xuanwen Bao
The immunometabolic basis of therapy-resistant colorectal cancer (CRC) peritoneal carcinomatosis with malignant ascites remains poorly defined. Here, we profile ascites immune cells from 20 patients across treatment-naive, chemo/targeted therapy-refractory, and immune checkpoint blockade (ICB)/adoptive T cell therapy (ACT)-resistant CRC. Single-cell RNA sequencing identifies SPP1 + cavity macrophages as drivers of CD8 + T cell dysfunction. Proteomic profiling of 36 patients confirms SPP1 enrichment in ICB/ACT-resistant peritoneal metastases. Mechanistically, SPP1 sustains an M2-like program via PPARγ activation and lipid uptake. SPP1 deficiency reduces PPARγ ligand precursors, triggering NF-κB-driven macrophage reprogramming and reversing CD8 + T cell suppression. Supplementation with 15 d-PGJ 2 and fatty acids restores the M2 phenotype. In vivo , macrophage-specific SPP1 knockout enhances cytotoxic T lymphocyte infiltration and ICB efficacy, while SPP1 neutralization overcomes ICB resistance and augments ACT efficacy. Thus, SPP1 + cavity macrophages are central immunometabolic regulators, and SPP1 inhibition represents a promising strategy to overcome immunotherapy resistance in this lethal disease.
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ACS Applied Nano Materials
·
2026
·Vol. 9
·期 29
·13771-13782
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IF 5.8
Tian Ying,Yu Shirong,Yu Xuebin,Kang Yongyin
Quantum
dots (QDs) have attracted considerable attention in wearable
electronics owing to their excellent optical properties, including
tunable bandgaps, narrow emission line widths, and high quantum yields.
Nevertheless, the weak chemical interaction between the surface ligands
of QDs and the polar moieties in polymer matrices impairs interfacial
compatibility, leading to ligand desorption and particle aggregation
during electrospinning. Herein, we report a viable strategy for creating
highly luminous QD/polymer nanofibers. Polar solvent processability
was achieved by replacing the pristine ligands with shorter-chain
6-mercaptohexanol (MCH). Through rational optimization of electrospinning
parameters and concentration, the QDs were effectively encapsulated,
achieving a photoluminescence quantum yield (PL QY) of 86.6%. Owing
to the dual protection of the polymer matrix and ligand-engineered
compatibility, the nanofibers exhibited significantly improved stability,
with the QY remaining as high as 84.0% after 36 days under ambient
conditions. Furthermore, a red light-emitting diode was fabricated
based on the nanofiber membranes, exhibiting a color purity exceeding
92.4%. This study provides a practical strategy for developing highly
luminescent and flexible nanofibers, highlighting their great potential
for applications in smart displays, intelligent textiles, and anticounterfeiting.
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Small
·
2026
·
IF 11.8
Chun Sun,Jiabao Bai,Ruifeng Wang,Zhengtao Qiu,Jiazhi Cui,Yuxin Zhang,Zekang Zang,Dan Huang,William W. Yu
Metal halide perovskites are promising photocatalysts for solar hydrogen production but suffer from severe water instability. Herein, a dual organic-inorganic encapsulation strategy is developed to construct water-resistant CsPbBr 3 nanocrystals. Hydrophobic zwitterionic ligands, in combination with an epitaxial CsPb 2 Br 5 shell, effectively isolate the CsPbBr 3 core from water while maintaining structural integrity. To overcome the carrier-blocking effect induced by encapsulation, hollow CoS x is introduced to form a sandwich-like heterostructure, in which CsPbBr 3 is spatially confined between CoS x and CsPb 2 Br 5 . This architecture enables directional charge transfer via a Schottky CoS x /CsPbBr 3 interface for efficient electron extraction and a type-II CsPbBr 3 @CsPb 2 Br 5 heterojunction for hole transport. Benefiting from the synergistic stabilization and charge-management effects, the resulting photocatalyst achieves a hydrogen evolution rate of 5.36 mmol h −1 g −1 with an apparent quantum efficiency of 4.19% at 420 nm, while maintaining stable performance over five cycles. This work provides a general strategy for integrating multi-layer encapsulation with carrier-selective interfaces to realize durable and efficient perovskite photocatalysts for aqueous hydrogen evolution.
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Small
·
2026
·
IF 11.8
Minan Ye,Yuanjun Li,Handi Deng,Shengjie Xu,Chengkang Li,Jinshuang Hu,Yuhan Shen,Zhenghao Xiao,Juan Xu,Cheng Ma,Hanjie Ying,Chenjie Zhu,Yi Zhou
Combining tumor-associated macrophage (TAM)-targeted immunotherapy with starvation therapy represents a promising strategy for enhancing antitumor efficacy. Energy metabolism and nitrosative stress represent two key metabolic pathways that can effectively guide the efficacy of the combination of TAM-targeted immunotherapy and starvation therapy. However, methods capable of simultaneously profiling of the dynamic interplay between energy metabolism and nitrosative stress during cancer starvation-immunotherapy (CSI) remains challenging. Here, we report a TAM-targeted dual-mode nanoprobe, NNDA, for real-time imaging of energy metabolism and M1-like TAM-mediated nitrosative stress during CSI. The nanoprobe was designed to comprise NAD(P)H-sensitive dye Glu-RB and NO-responsive dye CY-NO assembled on the surface of upconversion nanoparticles, showing excellent selectivity and sensitivity to energy metabolism-associated NAD(P)H and nitrosative stress-associated NO with two independent NIR photoacoustic (PA, 710/1064 nm) and upconversion luminescence (UCL, 660/800 nm) channels. In vitro and in vivo studies confirmed that NNDA accurately tracked metabolic reprogramming and TAM repolarization, revealing that CSI regimens sustain nitrosative stress under energy suppression. Importantly, the ratio R-PA 1064 /PA 710 serves as an early prognostic indicator of treatment outcome, displaying strong correlation with tumor growth inhibition. This work provides a cross-referencing imaging tool for dynamically deciphering metabolic-immune crosstalk, facilitating the screening and optimization of synergistic anticancer therapies.
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BMEMat
·
2026
·
IF 17.2
Siyu Pan,Xuanyi Lu,Wenjie Yang,Yunhui Peng,Lingfu Deng,Shuai Zha,Xueyang Fang,Guochen Bao,Lijun Jiang
Intratumoral L-lactate represents a valuable biomarker for both prognosis and therapy response, underscoring the importance of its accurate detection. However, traditional L-lactate assays rely on indirect hydrogen peroxide readouts and often compromise the accuracy and specificity. Herein, we report an aptamer-based nanoprobe (UCNP-Apt-Act) that allows direct L-lactate detection. Aptamers offer high specificity for L-lactate but suffer from poor cellular uptake and premature activation by extracellular L-lactate. To overcome this, we introduced lanthanide-doped upconversion nanoparticles (UCNPs) to enable spatially controlled unlocking by near-infrared (NIR) light for intratumoral L-lactate detection. The nanoprobe remains “locked” during delivery via an engineered actuator, preventing premature response to extracellular L-lactate. Upon 980 nm excitation, UCNPs convert NIR to UV emission, photocleaving the actuator linker and unlocking the aptamer. Notably, the UCNP carriers enhanced cellular uptake by 41 times through overcoming membrane barriers. The unlocked nanoprobe shows a 46-fold fluorescence enhancement in the presence of L-lactate, with an exceptional selectivity against a broad range of molecules and biological ions and metabolites. It enables specific detection of L-lactate in cancer cells, colorectal tumors, and diverse real samples, with excellent recoveries of 95.0%–110.0%. This strategy establishes a robust approach for endogenous small-molecule sensing and provides a versatile platform for biomedical applications.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Di Shen,Jianhao Ding,Yuhang Tan,Yujie Wen,Xinning Wang,Xiankan Zeng,Maolin Mu,Chenglong Li,Jingjing Cao,Xiaoqiang Fan,Weiqing Yang,Wen Li
TrTPFB is successfully introduced as a fluorinated ionic molecule into FAPbBr₃ PeQDs. • Multi-site interactions stabilize the PeQD surface and suppress nonradiative recombination. • TrTPFB induces p-type modulation, reducing interfacial charge accumulation. • Threefold enhancement in T₅₀ lifetime highlights improved device stability. Perovskite quantum-dot light-emitting diodes (PeQLEDs) remain limited by coupled surface and interfacial losses: labile ligand binding produces trap-rich perovskite quantum dot (PeQD) surfaces while unbalanced carrier injection accelerates interfacial charge accumulation and nonradiative recombination. Here, triphenylmethylium tetrakis(pentafluorophenyl)borate (TrTPFB) is introduced as a fluorinated ionic molecule to synergistically regulate both the surface coordination and charge-injection behavior of FAPbBr₃ PeQDs. Density functional theory (DFT) calculations reveal pronounced charge redistribution between TrTPFB and the PeQD surface. Experimental results show that the fluorinated tetrakis(pentafluorophenyl)borate (TPFB − ) anion and the positively charged triphenylmethylium (Tr + ) cation cooperatively stabilize the surface coordination environment and suppress trap-mediated nonradiative recombination. TrTPFB also induces p-type electronic modulation of the PeQD film, shifts the Fermi level toward the valence band, lowers the hole-injection barrier, and mitigates interfacial charge accumulation. Consequently, The combined operation of these mechanisms significantly improves the photoluminescence quantum yield (PLQY) of perovskite films to an impressive 98.50%. The corresponding green PeQLED achieves a peak external quantum efficiency of 17.50%, a maximum luminance of 80,859.28 cd m −2 , and an approximately threefold increase in the average T₅₀ lifetime compared with the control device. This work establishes a fluorinated ionic molecular strategy that integrates surface passivation and charge-injection regulation for efficient and stable PeQLEDs. Download: Download high-res image (115KB) Download: Download full-size image
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Shiwen Liu,Junyu Hong,Minghao Wang,Zupeng Liu,Youwang Long,Yuefei Xiang,Zaidong Chen,Lei Zhong,Titao Jing,Lei Zhou
Flexible electroluminescent displays represent a significant advancement beyond rigid technologies like LCDs, yet alternating current electroluminescent (ACEL) devices face limitations in color performance and brightness. This study introduces an innovative dielectric-luminescent coupling material, BaTiO 3 @CsPbX 3 (PeBTO), designed to enhance the color and brightness performance of flexible ACEL displays. The core-shell architecture synergistically combines the high dielectric constant of BaTiO 3 with the tunable narrow-band luminescence of perovskite quantum dots. When integrated into ZnS-based ACEL devices, PeBTO optimizes electric field distribution, which not only significantly increases the dielectric constant (from 4.41 to 28.71) but also enhances the luminance by approximately 121%. Leveraging a photoconversion mechanism, PeBTO enables multicolor displays by absorbing ZnS blue electroluminescence and re-emitting green/red light. Fully flexible devices demonstrate stable multicolor emission under mechanical deformation (folding, twisting, stretching), showcasing enhanced brightness and reliable color output. This work contributes to the development of efficient, flexible displays with synergistic dielectric-luminescent regulation.
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ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Baizong Fang,Wei Guo,Zhenyu Liu,Huakui Huang,Xiaohong Zhong
Background The detection and imaging of intracellular biomarkers can provide important information for the early diagnosis of cancer. Leveraging the inherent advantages of DNA such as biocompatibility, ease of synthesis, programmability, and sequence-specific recognition, DNA-based probes have been widely employed for biomarker analysis. Currently, a variety of DNA probes combined with signal amplification methods have been widely used to visualize biomarkers in living cells. However, conventional single-locked DNA probes cannot ensured the accurate diagnosis. Furthermore, the lack of efficient cascade signal amplification strategies makes it challenging to detect and image low-abundance biomarkers. Results In this work, we report a dual-locked, self-feedback catalytic hairpin assembly (CHA)-DNAzyme cascade amplification platform, termed hMNS@SCD. This platform utilizes MnO 2 nanoflowers as nucleic acid carriers and DNAzyme cofactor supplement, employing apurinic/apyrimidinic endonuclease 1 (APE1) and miR-21 as two molecular keys. When the APE1 and miR-21 existence, hairpin probe carry out the CHA cycle, leading to the assembly of a Y-shaped DNAzyme complex. When Mn 2+ is present, the Y-shaped DNAzyme can undergo a hybridization-cleavage-release cycle on the MB, leading to a gradual restoration of Cy5 fluorescence. In addition, the released target analogue from MB can trigger a new CHA cycle, generating more Y-shaped DNAzyme complexs and cleaving more MB, further amplifying the fluorescence signal. Through the self-feedback CHA-DNAzyme cascade amplification mechanism, hMNS@SCD effectively enhances the detection sensitivity, with a detection limit for miR-21 reaching 34.6 fM. Experimental data show that hMNS@SCD has high sensitivity, selectivity, and biocompatibility. Significance we constructed a dual-locked, self-feedback CHA-DNAzyme cascade nanomachine, which enables tumor-specific molecular imaging and effectively distinguishes between normal cells and cancer cells. In addition, due to the programmability of nucleic acid probes, this strategy can be readily adapted for detection and imaging of other low-abundance biomarkers, offering a promising way forward for tumor-specific molecular imaging and early cancer diagnosis.
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