JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 15
·7694-7705
·
IF 4.682
Li Haiyang,Lin Lanlan,Su Sisi,Wen Xinyu,Yan Rui,Liu Hongmei,Tao Caihong
Near-infrared photothermal nanomaterial is expected to synergize chemotherapy and photothermal therapy, which provided a higher tumor therapeutic effect than single therapy. In this article, the hollow mesoporous polydopamine (HMPDA) microcapsules modified with gold (Au) nanoparticles (NPs) were prepared as nanodrug carriers using silica as the templates. The adsorption properties of HMPDA@AuNPs microcapsules for methylene blue (MB) dyes were studied, as well as the load and release properties for adriamycin hydrochloride (DOX) and in vitro cytotoxicity. Finally, the photothermal properties of the above microcapsules were investigated. The results showed that the HMPDA@AuNPs microcapsules had high photothermal conversion efficiency, the average DOX capacity of the carriers was 334.78 mg/g within 24 h, and the release rate was about 44.8% under photothermal conditions within 8 h. The preparation process of HMPDA@AuNPs microcapsules was simple and mild, with excellent drug loading capacity, pH-targeted release performance, good photothermal property and biocompatibility. The combination of chemotherapy and photothermal therapy made it valuable as a drug carrier in the application of tumor diagnosis and treatment.
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高影响因子
Journal of Nanomaterials
·
2017
·
IF 1.871
Yaoyao Yang,Jiali Zhang,Fangwei Zhang,Shouwu Guo
Composites of gold nanoparticles and graphene quantum dots (AuNPs/GQDs) exhibit excellent dispersibility in aqueous solutions. Thus, it is difficult to separate them from wet reaction systems when they are used as catalysts. To resolve this issue, in this study, an AuNPs/GQDs composite was immobilized on silicon dioxide through the hydrothermal method, which involved the formation of an amide bond between the surface GQDs of the AuNPs/GQDs composite and the amino group of the silane. The as-synthesized AuNPs/GQDs/SiO2 composite was found to be suitable for use as a heterogeneous catalyst for the oxidation of veratryl alcohol in water and exhibited catalytic activity comparable to that of bare AuNPs/GQDs as well as better recyclability.
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Chemical Engineering Journal Advances
·
2022
·
IF 0
Wei Xue,Bo Han,Haojie Ma,Xueyan Hou,Ji-Jiang Wang,Ran Li,Yuqi Zhang
Novel TiO 2 nanotube arrays (TNAs) involved heterojunctions are widely used as photocatalyst for pollutants, while the residues are usually detected by other method. A device which integrates photocatalytic degradation and enhancing detection signals could increase the atom utilization and decrease detection cost. In this work, a novel TNAs/g-C 3 N 4 /AuNPs heterojunction was prepared and used as photocatalyst and SERS substrate simultaneously. Dye of crystal violet was successfully degraded, and the concentration of residue was detected by Raman spectroscopy. There was a good linear correlation between the Raman intensity and the concentration of crystal violet from 10 −10 M to 10 −6 M, and the limit of detection (LoD) was 8.79 × 10 −11 M. Moreover, the prepared heterojunctions were used on wastewater and biological staining detection. In the applications of photocatalytic degradation and detection, the time-dependent SERS intensities demonstrated the photocatalytic degradation achieved more than 95% in 20 min, and almost completed in 25 min, and the heterojunctions showed good recyclability in at least 10 cycles. For SERS property, the original enhancement factor (EF) was calculated to be 7.43 × 10 6 , then the EF descended slightly and remained with less than 90% attenuation after 10 cycles.
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2023
·Vol. 170
·期 4
·047509
·
IF 3.9
Mengli Wang,Lele Ma,Le Kang,Mingsan Miao,Huaixia Yang
Estrogen receptor alpha (ERα) is an important biomarker for breast cancer which is positive in over 75% of breast cancer cases. In this study, an electrochemical biosensor was constructed for sensitive detection of ERα based on the signal amplification of AuNPs-SWCNT nanocomposites and hemin@HKUST-1. AuNPs-SWCNT was served as a conductive substrate, and be used to immobilize the aptamer (Apt) by an Au–S bonding. Then, Apt, ERα and antibody (Ab) formed a sandwich composite structure through specific recognition and immobilized on the electrode. The hemin@HKUST-1 was introduced into the biosensor via an amide bond with Ab and acted as the signal molecule. AuNPs-SWCNT could significantly enhance the conductivity of the electrode and the large specific surface area of HKUST-1 enabled it to load more hemin, and greatly improved the sensitivity of the biosensor. The detection limit (LOD) of the biosensor could reach 27.8 fg·ml−1 after optimization of the conditions, with the current intensity and the logarithm of the ERα concentration exhibited a good linear relationship between 100 fg·ml−1 and 100 ng·ml−1. In addition, the biosensor possessed excellent selectivity, stability, reproducibility and Interference immunity. More importantly, it shows great application potential in practical detection.
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高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 3
·1-11
·
IF 5.3
Liu Huamin,Li Chenghong,Wang Lina,Fang Lichao,Huang Hui,Deng Jun,Hu Yue,Li Mimi,Ran Xiaoping,Li Lulu,Zheng Junsong
A “signal-off” photoelectrochemical (PEC) sensing platform has been designed for the ultrasensitive detection of DNA methylation levels and multiple methylated sites. The platform employs tungsten trioxide and TpPa-1-COF loaded by gold nanoparticle (AuNPs@WO 3 @TpPa-1-COF) composite material as the photoactive component and p-type reduced graphene (rGO) as an efficient quencher. The PEC signal of AuNPs@WO 3 @TpPa-1-COF composite is effectively quenched in the presence of p-type rGO, because p-type rGO can compete with AuNPs@WO 3 @TpPa-1-COF to deplete light energy and electron donors. In addition, a hybrid strand reaction (HCR) amplification strategy fixes more target DNA and then combines with rGO-modified anti-5-methylcytosine antibody to facilitate ultrasensitive DNA methylation detection. Under optimal conditions, DNA methylation can be measured within a linear concentration range of 10 –14 to 10 –8 M, with an exceptionally low detection limit of 0.19 fM (S/N = 3). At the same time, the platform can conduct quantitative determination of multi-site methylation, with the linear equation △I = 44.19Log A + 61.43, and the maximum number of methylation sites is 5. The sensor demonstrates high sensitivity, excellent selectivity, and satisfactory stability. Furthermore, the proposed signal-off PEC strategy was successfully employed to detect DNA methylation in spiked human serum samples, with recoveries ranging from 93.17 to 107.28% and relative standard deviation (RSD) ranging from 1.15 to 5.49%. Graphical
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PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Jia An,Mengfei Luo,Meizheng Li,Hongyuan Cui,Yufei Liu
Choline, as an important neurotransmitter and metabolic substance, plays an important role in human metabolism, information transmission, regulation of apoptosis, and promotion of fat metabolism, etc. Its level changes and metabolic abnormalities can also be used as diagnostic markers for a variety of diseases. In this study, we developed an advanced electrochemical choline biosensor by modifying the electrode surface with MXene, multi-walled carbon nanotubes functionalized with gold nanoparticles (MWCNT-AuNPs), and Fe 3 O 4 nanoparticles (Fe 3 O 4 NPs). MWCNT will be interspersed with MXene to avoid strong interlayer aggregation. At the same time, the composite of AuNPs and MWCNT can avoid the agglomeration of Au and further improve the conductivity under the synergistic effect. Improve sensor performance through synergistic effect, this combination of multi-component nanomaterials may provide higher electron conduction efficiency and current response rates. The electrochemical sensors, which were doped with various nanomaterials, were thoroughly investigated utilizing electrochemical impedance spectroscopy (EIS) in conjunction with time–current curve analysis. The findings demonstrated that the MXene/MWCNT-AuNPs/Fe 3 O 4 NPs nanocomposites possess a substantial specific surface area, an abundance of active sites, and enhanced electrical conductivity, all of which contributed to the improved conductivity and current response of the enzyme electrode. The resulting biosensor demonstrated superior sensitivity and selectivity for choline detection compared to previously reported electrodes. Specifically, it exhibited a linear range of 0.033–133.33 μM, a sensitivity of 8.8nA/μM, a response time of 5 s, and a detection limit of 22 nM. Importantly, the sensor showed high accuracy in detecting choline levels in human serum and cerebrospinal fluid samples, indicating its potential for practical applications in real-world clinical settings. This advancement holds promise for the effective prevention of the recurrence of glioma, Alzheimer’s disease, Parkinson’s disease, and other related conditions.
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高影响因子
ANALYST
·
2015
·Vol. 140
·期 23
·8017-8022
·
IF 4.107
Jun Lv,Xiaonan Wang,Yuanyuan Zhang,Defeng Li,Juan Zhang,Lizhou Sun
Based on the adsorption between tetracycline (TC) and phosphate groups, a general colorimetric method is explored in this work by using TC-stabilized gold nanoparticles (TC/AuNPs) and 4-aminophenyl phosphate-functionalized Fe3O4 magnetic nanoparticles (APP/MNPs). Taking protein tyrosine phosphatase 1B (PTP1B) as an example, 4-aminophenyl phosphate (APP) can be hydrolyzed into 4-aminophenol (AP) by PTP1B, resulting in the disappearance of the phosphate group on the outer layer of MNPs and the loss of corresponding adsorptive ability. Upon addition of TC/AuNP solution, TC/AuNPs will remain in the supernatant solution after magnetic separation and a high absorbance value can be observed. So PTP1B activity is related to the concentrations of TC/AuNPs in the supernatant solution. In this work, the enzyme activity can be determined at levels as low as 0.0885 U mL−1 and over a linear detection range as wide as 0.1 U mL−1 to 0.9 U mL−1. Moreover, using the proposed method, the inhibition effect of betulinic acid (BA) and sodium orthovanadate (Na3VO4) on PTP1B activity can be tested with IC50 values of 30 μM and 4 μM, respectively. Therefore, a universal platform for the accurate colorimetric analysis of kinase and phosphatase activities can be established through the adsorption between TC and phosphate groups.
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PubMed
高影响因子
ELECTROANALYSIS
·
2025
·Vol. 37
·期 5
·e12050
·
IF 2.3
Sumin Xu,Wenjing Liu,Jinjin Zhang,Jianying Qu
In this work, Cu nanosphere-anchored Cu-based MOF derivants were synthesized by high-temperature calcination using Cu(BDC) as precursors and then combined with gold nanoparticles to give AuNPs/Cu/C composites. The proposed materials were characterized by SEM, XRD, XPS, FTIR, and EIS. Based on these composites, a sensor was constructed, which showed good electrocatalytic activities to the redox of acetaminophen (PA) and P-aminophenol (4-AP) and could be used to detect them simultaneously. Under optimal experimental conditions, the linear ranges for detection of PA and 4-AP were 0.50–150.00 and 0.50–120.00 μM with the detection limits of 0.056 and 0.084 μM, respectively. Thanks to the hierarchical and porous structural characteristics of the Cu/C material and its synergistic effect with AuNPs, it shows good sensing performance in the simultaneous detection of PA and 4-AP. The sensor has wider linear ranges, lower detection limits, good selectivities, and higher accuracies with potential environmental detection application prospects.
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高影响因子
Advanced Healthcare Materials
·
2019
·Vol. 9
·期 1
·1901229
·
IF 6.27
Shi-Zhao Lu,Xiao-Yan Guo,Mei-Shuai Zou,Zi-Qin Zheng,Yu-Chuan Li,Xiao-Dong Li,Li-Li Li,Hao Wang
The emergence of drug-resistant bacteria is becoming the focus of global public health. Early-stage pathogen bioimaging will offer a unique perspective to obtain infection information in patients. A photoacoustic (PA) contrast agent based on functional peptide modified gold nanoparticles (AuNPs@P1) is developed. These nanoparticles can be specifically tailored surface peptides by bacterial overexpressed enzyme inducing in situ aggregation of the gold nanoparticles. In the meantime, the close aggregation based on the hydrogen bonding, π–π stacking, and hydrophobic interaction of the peptide residues on the surface of gold nanoparticles exhibits a typical redshifted and broadened plasmon band. In addition, this active targeting and following in situ stimuli-induced aggregation contribute to increased nanoparticle accumulation in the infected site. Finally, the dynamic aggregation of AuNPs@P1 results in dramatically enhanced photoacoustic signals for bioimaging bacterial infection in vivo with high sensitivity and specificity. It is envisioned that this PA contrast agent may provide a new approach for early detection of bacterial infection in vivo.
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PubMed
高影响因子
Analytical Methods
·
2016
·Vol. 8
·期 22
·4391-4397
·
IF 1.915
Juan Zhao,Wenjuan Guo,Meishan Pei,Feng Ding
In this work, a novel electrochemical aptasensor was developed for the sensitive detection of the antibiotic penicillin, which used a penicillin aptamer as the specific recognition element and a novel composite film consisting of a magnetic graphene nanocomposite (GR–Fe3O4NPs) and a poly(3,4-ethylenedioxythiophene)–gold nanoparticles composite (PEDOT–AuNPs) as the platform. Firstly, GR–Fe3O4NPs was fabricated on a bare glassy carbon electrode (GCE) surface. Secondly, the first film was modified with the PEDOT–AuNPs composite and the as-modified electrode had a much larger surface area and a greatly improved electronic transmission rate. Subsequently, a penicillin aptamer was assembled on the modified electrode via Au–N bonds between the AuNPs and –NH2 groups of the aptamer. The structures of the GR–Fe3O4NPs and PEDOT–AuNPs composite have been investigated by scanning electron microscopy (SEM). Cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV) were used to demonstrate the electrochemical performance of the as-prepared aptasensor. Under optimized conditions, the proposed aptasensor exhibited high sensitivity for the detection of penicillin with a wide linear range from 0.1 to 200 ng mL−1 and a low detection limit of 0.057 ng mL−1. The proposed aptasensor also showed good stability, satisfactory reproducibility and high specificity. Finally, the proposed aptasensor was successfully used for the detection of penicillin in a real sample.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Xiaolu Li,Si Wu,Tao Feng,Tong Wu,Xu Zhu
Gold nanoparticles (AuNPs) exhibit excellent catalytic activity but face significant practical constraints, such as insufficient stability and difficult recovery. This study employed a quercetin-mediated green reduction method with chitosan as a stabilizer to synthesize Chitosan/AuNPs (Chit/AuNPs) capable of maintaining long-term dispersion stability (960 h). It was clearly demonstrated that the chitosan dosage is critical for controlling the size of AuNPs, with 0.8 mL of chitosan yielding smaller AuNPs with an average particle size of about 16.8 nm. Subsequently, Chit/AuNPs were immobilized within a calcium alginate network via electrostatic attraction and Ca 2+ cross-linking, successfully fabricating reusable Chitosan/AuNPs@Calcium Alginate (Chit/AuNPs@CaA) composite microspheres. The catalyst exhibited high activity at room temperature, achieving a 4-NP conversion rate of 97.0% within 25 min with an apparent rate constant (k) of 0.168 min −1 . Notably, after five consecutive uses, the conversion rate remained at 96.9% within 25 min, confirming its reliability as a reusable catalyst. Furthermore, in real water samples, the catalyst maintained over 96.1% conversion rate, demonstrating strong environmental tolerance. This research contributes to the development of novel catalytic materials with high activity, remarkable stability, and practical application potential.
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高影响因子
Science China-Materials
·
2018
·Vol. 61
·期 5
·728-736
·
IF 4.318
Li Kaikai,Jiao Tifeng,Xing Ruirui,Zou Guodong,Zhou Jingxin,Zhang Lexin,Peng Qiuming
MXene, a new type of two-dimensional layered transition metal carbide material differing from graphene, demonstrates intriguing chemical/physical properties and wide applications in recent years. Here, the preparation of the self-assembled MXene-gold nanoparticles (MXene@AuNPs) nanocomposites with tunable sizes is reported. The nanocomposites are obtained via the self-reduction reactions of MXene material in a HAuCl 4 solution at room temperature. The sizes of the Au particles can be well-controlled by regulating the self-reduction reaction time. They can greatly influence the catalytic behaviors of the MXene@AuNPs composites. MXene@AuNPs composites with optimized reduction time show high catalytic performances and good cycle stability for model catalytic reactions of nitro-compounds, such as 2-nitrophenol and 4-nitrophenol. This work demonstrates a new approach for the preparation of tunable MXene-based self-assembled composites.
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