JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2024
·Vol. 171
·期 4
·047514
·
IF 3.1
Xuemei Ma,Wanyu Pang,Yali Gao,Xile Chang,Zhiyong Hu,Tuoping Hu
Rapid and accurate determination of rutin content in pharmaceuticals in an important issue. Here, a paper-based electrochemical sensor for in situ growth of chain ZIF-8 using multi-walled carbon nanotubes (MWCNTs) as a template was constructed by hydrothermal method. The results showed that the combination of ZIF-8 and MWCNTs not only promoted the dispersion of MWCNTs, but also made up for the conductivity of ZIF-8. Under optimum conditions, the Ipa was linearly related to the concentration of rutin in the range of 0.01–10 and 10–190 μM with a limit of detection (LOD) of 2.82 nM. Finally, the paper-based electrochemical sensor can be used for the electrochemical detection of rutin through the determination of rutin in pharmaceuticals.
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Scientific Reports
·
2025
·Vol. 15
·期 1
·1-16
·
IF 3.9
Wang Qing,Chen Jie-Jie,Qiu Bin,Zhou Liang,Liu Rui-Ye,Huang Jia-Fen,He Yan,Xie Qin
Taking the extraction amount of rutin as the index, the extraction process of rutin from Ilex asprella (Hook. et Arn.) Champ. ex Benth. using the ultrasonic-assisted deep eutectic solvent method was optimized through response surface method. The effects of various factors, including the types of deep eutectic solvent, molar ratio of the solvent, water content, liquid-solid ratio, the temperature, power and time of ultrasound on the extraction amount of rutin were investigated. In accordance with the result of univariate experiments, the extraction process was optimized through employing the Box-Behnken response surface design method. A three-factor, three-level experimental model was established with the liquid-solid ratio, water content and ultrasonic time as variables. The findings indicated that the optimal technological conditions were as stated below: the molar ratio of lactic acid to choline chloride at 1:1, the ultrasonic extraction temperature at 40 °C, the ultrasonic extraction time at 31 min, the water content at 28%, and the liquid-solid ratio at 20:1 mL/g. Under optimal conditions, the validation experimental result revealed that the extraction amount of rutin was 86.553 ± 1.35 µg/g, with an absolute error of less than 0.6% in comparison with the predicted value of the model. The use of deep eutectic solvents for the extraction of rutin and the application of response surface method for optimizing the extraction process of rutin from Ilex asprella (Hook. et Arn.) Champ. ex Benth. were demonstrated. The present study provided a reference for the comprehensive utilization of Ilex asprella (Hook. et Arn.) Champ. ex Benth. .
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Xinyu Huang,Junhong Li,Huan Zhang,Xuemin Duan,Lihua Yao,Ruirui Yue,Jingkun Xu
As a natural flavonoid glycoside, rutin has been made into many medical products due to its unique pharmacological activity. However, excessive intake of rutin is harmful to health. Therefore, developing a new sensing technique to achieve highly sensitive, rapid and on-site detection of rutin is of great significance to ensure food and medicine safety. Herein, an electrochemical sensing platform was proposed based on the nanocomposite of functionalized multi-wall carbon nanotubes/poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)/Ru nanoparticles (MWCNT-COOH/PEDOT:PSS/Ru) for rutin detection. The characterization techniques reveal that MWCNT-COOH and PEDOT:PSS crossed together forming a 3D interconnecting structure with plenty of areolations and high specific surface area, and Ru nanoparticles uniformly dispersed on the surface of MWCNT-COOH/PEDOT:PSS. Moreover, due to the good film reforming property of PEDOT:PSS, the as-obtained MWCNT-COOH/PEDOT:PSS/Ru composite shows special surface appearance as flexible free-standing film, which can be freely cut and used as sensing platform directly. Electrochemical experiments confirmed that MWCNT-COOH/PEDOT:PSS/Ru composite film performed satisfactory sensing properties toward rutin detection with wide linear ranges of 0.01 ∼ 0.7 μM and 0.7 ∼ 50 μM, low detection limit of 6.1 nM and high sensitivity of 79.43 μA μM −1 cm −2 . Besides, the composite sensing platform also exhibits high selectivity, reproducibility, and stability. During actual sample testing, the sensing platform was successfully applied for rutin detection in rutin pharmaceutical tablets and black buckwheat tea, showing promising application prospects in rapid, convenient, and high-efficiency on-site test.
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Italian Journal of Animal Science
·
2025
·
IF 2.3
Huai Shi,Jiaqi Zhang,Huijuan Liu,Shun Chen,Minhang Tu,Gentan Cai,Tong Jin,Tian Wang,Chao Wang
The benefits of rutin administration were evaluated, focusing on effects on broiler growth performance, intestinal barrier, mitochondrial homeostasis, and redox balance under heat stress. The results demonstrated that compared to the HS group, dietary rutin improved growth performance (increasing final body weight, average daily feed intake, and average daily gain), jejunal morphology (expanding villus width and surface area), jejunal barrier (elevating concentrations of Occludin, Claudin-1, and Mucin-2; upregulating mRNA expression of Occludin and Mucin-2), redox balance in both serum and jejunum (boosting total antioxidant capacity, superoxide dismutase activity, glutathione levels, and the glutathione-to-oxidised glutathione ratio; increasing mRNA expression of glutathione S-transferase and nuclear factor erythroid 2–related factor 2), and jejunal mitochondrial homeostasis (amplifying mitochondrial DNA copy number and ATP synthase α-subunit mRNA levels) (p < 0.05). Moreover, dietary rutin reduced the ratio of feed to gain, lowered liver alkaline phosphatase activity, decreased concentrations of serum diamine oxidase and malondialdehyde, reduced jejunal oxidised glutathione levels, and downregulated jejunal mucosa mRNA expression of B-cell lymphoma 2 associated X, kelch-like ECH-associated protein 1, and heat shock protein 90 (p < 0.05). Overall, rutin supplementation (optimal dose of 500 mg/kg) effectively attenuates HS-induced decline in broilers’ growth performance, impairment of intestinal morphology and barrier integrity, disruption of mitochondrial homeostasis, and redox imbalance, potentially through Nrf2-mediated mechanisms.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Shengxiang Fu,Zhongyuan Cai,Haojie Gu,Su Lui,Hua Ai,Bin Song,Min Wu
Manganese oxide nanoparticles (MONs)-based contrast agents have attracted increasing attention for magnetic resonance imaging (MRI), attributed to their good biocompatibility and advantageous paramagnetism. However, conventional MONs have poor imaging performance due to low T 1 relaxivity. Additionally, their lack of tumor-targeting theranostics capabilities and complex synthesis pathways have impeded clinical applications. Rutin (Ru) is an ideal tumor-targeted ligand that targets glucose transporters (GLUTs) overexpressed in various malignant tumors, and exhibits photothermal effects upon chelation with metal ions. Herein, a series of Ru-coated MONs (Ru/MnO 2 ) were synthesized using a straightforward, rapid one-step process. Specifically, Ru/MnO 2 -5, with the smallest crystal size of approximately 4 nm, exhibits the highest T 1 relaxivity (33.3 mM -1 s −1 at 1.5 T, surpassing prior MONs) along with notable stability, photothermal efficacy, and tumor-targeting ability. Furthermore, Ru/MnO 2 -5 shows promise in MRI and photothermal therapy of H22 tumors owing to its superior GLUTs-mediated tumor-targeting capability.
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Journal of Functional Foods
·
2025
·
IF 4
Lifang Feng,Tianyu Zhang,Wei Ye,Daofeng Qu
Resveratrol and rutin, two polyphenolic compounds, can effectively alleviate the symptoms of ulcerative colitis (UC), leading to conflicts in recommending resveratrol- or rutin-rich diets to UC patients, who do not know which type of diet is more effective in alleviating UC symptoms. In this study, administration of resveratrol or rutin alleviated DSS-induced UC mice, including reduction of DAI, serum levels of inflammatory cytokines and oxidant, and improvement of colonic health status. Differentially expressed genes resulting from resveratrol and rutin treatment in DSS-induced UC mice at the genome-wide level from scratch and elucidated the mechanism by which they affected the polarization of intestinal epithelial T cells by promoting Treg cells and inhibiting Th17 cells to alleviate UC symptoms, and rutin was greater than resveratrol. In addition, rutin-rich foods were superior to resveratrol-rich foods in ameliorating UC symptoms in mice. Our findings suggest that UC patients consume rutin-rich foods to better alleviate intestinal inflammation.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Liuzhu Zhou,Ling Cai,Hongjie Ruan,Li Zhang,Jun Wang,Huijun Jiang,Yuan Wu,Shanwu Feng,Jin Chen
Burn injury has posed devastating burdens on the public health due to its inevitable damage to the skin structure resulting in the increased risk of infection. Therefore, it is highly demanding to develop efficacious antibacterial wound-healing dressing. Despite the favourable wound-healing activities, the curative efficacy of phytochemical compounds of quercetin (Qe) and its derivatives is limited by their poor water solubility. Here, we have fabricated a novel electrospun nanofiber membrane (ENM) consisting of polycaprolactone (PCL), chitosan oligosaccharides (COS), and Qe/Rutin (Ru) as the potential bioactive dressing for wound healing. The incorporation of chitosan oligosaccharides (COSs) in the PCL scaffold at the optimized molar ratio not only contributed to the improved hydrophilicity and water absorption performance of the ENM but effectively increased the specific surface area of the formed nanofibers. In particular, the antioxidant and antibacterial activities of the Qe/rutin-loaded nanofiber membranes were tested, which revealed that the PCL-COS-Qe membrane exhibited superior performance among all nanofiber membranes. Therefore, the developed PCL-COS-Qe/Ru nanofiber membranes hold enormous potential as healthcare products, such as wound dressings for burn injuries.
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PubMed
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Analytical Methods
·
2019
·Vol. 11
·期 28
·3584-3589
·
IF 2.378
Yanqiong Lai,Xia Teng,Yanli Zhang,Hongbin Wang,Pengfei Pang,Chun Yang,Colin J. Barrow,Wenrong Yang
In this study, we developed a simple, sensitive, low-cost and label-free method to detect rutin by using double-stranded DNA-templated copper nanoclusters (dsDNA-CuNCs) as a fluorescent probe. The dsDNA-template can facilitate the formation of highly fluorescent CuNCs with a maximum emission wavelength of 575 nm. In the dsDNA-CuNC fluorescent probe, rutin was intercalated into the structure of dsDNA via hydrogen bonding and electrostatic interactions. The fluorescence of dsDNA-CuNCs was quenched considerably due to the electron transfer from CuNCs to rutin. This decrease in the fluorescence intensity of dsDNA-CuNCs can be used to monitor the concentration of rutin from 0.6 to 400 μM with a detection limit of 0.12 μM (S/N = 3). Compared with the previous reports, this method does not require any complex DNA sequence design, fluorescent dye label and sophisticated experimental techniques. Moreover, the proposed sensing system could be applicable for the detection of rutin in pharmaceutical samples.
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Frontiers of Chemical Science and Engineering
·
2023
·Vol. 17
·期 6
·735-748
·
IF 4.5
Meng Rongqian,Tang Jianke,Yang Hong,Guo Lijun,Song Yongbo,Li Qiaoling,Niu Yulan
In this study, a simple and effective method was proposed to improve the electrocatalytic ability of overoxidized poly(3,4-ethylenedioxythiophene)-overoxidized polypyrrole composite films modified on glassy carbon electrode for rutin and luteolin determination. The composite electrode was prepared by cyclic voltammetry copolymerization with LiClO 4 -water as the supporting electrolyte. The peak current of rutin and luteolin on the composite electrode gradually decreased or even disappeared with the increase in the positive potential limit. After incubation in NaOH-ethanol solution with a volume ratio of 1:1, the composite electrodes prepared at positive potential limit greater than 1.5 V exhibited enhanced differential pulse voltammetry peak currents, reduced charge transfer resistance, larger effective specific surface area and higher electron transfer rate constant. The composite electrode prepared in the potential range of 0–1.7 V showed optimal electrocatalytic performance. The X-ray photoelectron spectroscopy results indicated that the content of −SO 2 /−SO and −C=N− groups in the composite film increased significantly after incubation. Further, the Raman spectra and Fourier transform infrared spectra revealed that the thiophene ring structure changed from benzene-type to quinone-type, and the quinone-type pyrrole ring was formed. The electrocatalytic mechanism of the composite film was proposed based on the experimental results and further verified by Density Functional Theory calculation.
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NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 37
·16045-16053
·
IF 3.288
Yang Ma,Mingming Li,Keren Shi,Zhifeng Chen,Baozhong Yang,Deyu Rao,Xiawei Li,Wei Ma,Shaozhang Hou,Guojing Gou,Huiqin Yao
Based on semi-interpenetrating polymer network (semi-IPN) hydrogel films, a multiple stimuli-responsive film system composed of poly(acrylic acid) (PAA) and N,N-diethyl acrylamide (DEA), designated as PAA–PDEA semi-IPN films, was realized on a glassy carbon (GC) electrode surface with a one-step polymerization method. Rutin (RT), an electroactive probe, displayed invertible pH-, thermo- and SO42− concentration–sensitive cyclic voltammogram (CV) behaviors in the film system. This multiply sensitive electrocatalysis of RT at the PAA–PDEA films was employed to further investigate the multiple stimuli-responsive ON–OFF behaviors of RT. The scanning electron microscopy (SEM) images and control experiments showed pH-sensitive ON–OFF properties of RT, which could be ascribed to the protonated/deprotonated carboxylic (–COOH) groups of the PAA component in different pH buffers and the properties of RT itself. However, the confirmation change or phase transition of the PDEA hydrogel film between the coil and globular states led to thermo- and SO42− concentration–sensitive ON–OFF properties. According to these results, a 3-input/3-output logic gate and a 2-to-1 encoder were constructed successfully. This present system was fabricated for the first time, which may offer numerous possibilities for the design of new electrochemical drug sensors, drug-mimicking release processes and other medical applications. Furthermore, it also can contribute to the development of biomolecular or molecular computing.
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International Journal of Electrochemical Science
·
2023
·
IF 1.5
Liying Wei,Xiaokun Li,Suxiang Feng
In this paper, a CdSe quantum dots (QDs) sensitized TiO 2 photoanode was synthesized by molten-salt-assisted self-assembly (MASA) on a fluorine-doped tin oxide (FTO)-coated glass (CdSe QDs-TiO 2 /FTO), and an efficient photoelectrochemical (PEC) sensor was constructed for the sensitive detection of rutin. CdSe can transfer photo-excited electrons to the conduction band of TiO 2 , thus enhancing the photoelectric activity of TiO 2 . The experimental results show that the PEC sensor has excellent selectivity, good stability, and a wide linear response range for rutin of 0.025–50.0 μM with a low detection limit of 0.007 μΜ. Moreover, the PEC sensor was successfully applied to the detection of rutin content in serum sample.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2014
·Vol. 32
·期 8
·1019-1031
·
IF 1.42
Wu Li-ping,Zhang Long,Lu Li-min,Duan Xue-min,Xu Jing-kun,Nie Tao
A novel graphene oxide doped poly(hydroxymethylated-3,4-ethylenedioxythiophene) (PEDOT-MeOH/GO) composite film was synthesized and utilized as an efficient electrode material for simultaneous detection of rutin and ascorbic acid (AA). PEDOT-MeOH/GO films were synthesized on glassy carbon electrode (GCE) by a facile one-step electrochemical approach and were characterized by scanning electron microscopy, UV-Vis spectroscopy, FTIR spectra and electrochemical methods. Then the PEDOT-MeOH/GO/GCE was applied successfully in the simultaneous detection of rutin and AA. The results showed that the oxidation peak currents of rutin and AA obtained at the PEDOT-MeOH/GO/GCE were much higher than those at the traditional conducting polymer PEDOT/GO/GCE, PEDOT-MeOH/GCE, PEDOT/GCE and bare GCE. Under optimized conditions, the linear ranges for rutin and AA are 20 nmol/L−10 μmol/L and 8 μmol/L−1 mmol/L, respectively. The detection limit is 6 nmol/L for rutin and 2 μmol/L for AA (S/N = 3), which are lower than those of the reported electrochemical sensors.
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