Nature Communications
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2026
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IF 18.1
Liu Xiang,Zhou Tiancong,Yuan Bo-Jun,Shi Qiujin,Zhou Peiyun,Wang Ye,Li Jing,Zhang Chunyu,Shao Mingfei,Duan Haohong
Electrooxidation of organic compounds to produce organic acid in an acidic electrolyte can circumvent product acidification step with high cost in alkaline electrolyte. However, catalysts often suffer from low stability in acid owing to severe leaching. Herein, we report a strategy to dynamically attract leached metal species to stabilize catalyst in a strong acid. In electrooxidation of glucose to formic acid over a lead dioxide (PbO 2 ) catalyst, switching the electrolyte from HClO 4 to H 2 SO 4 reduces Pb 2+ leaching by up to 30 times. As a result, a 275-hour stable performance at 1 A cm ‒2 is achieved in H 2 SO 4 (pH 0.3) using a membrane electrode assembly. Experimental evidence demonstrates that the SO 4 2− ion attracts the leached Pb 2+ —generated from chemical reduction of PbO 2 by glucose—by in-situ forming PbSO 4 precipitate on the electrode, which is then oxidized to the active PbO 2 phase. Benefiting from acidic electrolysis, we achieve raw cellulose conversion to formic acid without intermediate separation through an acid hydrolysis−electrolysis tandem process. This work demonstrates an efficient strategy to stabilize electrocatalysts that suffer from leaching issues in acidic conditions.
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Communications Materials
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2026
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IF 9.1
Ma Wei,Zhang Jin-Yan,Wang Dun,Li Zhi-Cheng,Cheng Xiang-Yi,Chen Ling-Long,Liu Ying,Kang Gui-Ying,Yu Cui-Yun,Wei Hua
The leverage of synthetic polymer self-assemblies (SPSAs) as biomimetic allostery provides unique opportunities for developing bio-inspired soft species. However, the preparation of these soft species remains a challenge likely due to the synthetic difficulties toward SPSAs having four-level hierarchical structural transitions and the compromised colloidal stability of the self-assembled quaternary structures. Herein, we report self-assembly of topological polymers with hydrophilic multicycles (HMCs) for biomimetic allostery. Specifically, cationic copolymers containing HMCs are prepared via a reliable synthetic approach, whose hierarchical self-assembly affords stabilized nanoparticles that undergo biomimetic allostery into quaternary petalled self-assemblies at an intracellular acidic pH of 5.0. The quaternary petalled self-assemblies lead to a mechanical disruption effect on lysosomes like nanomachines, further resulting in enhanced drug delivery efficiency of an anticancer drug-loaded multicyclic copolymers with a tumor inhibition rate 1.6-fold greater than that of the free drug in a murine 4T1 model. Overall, our work highlights the use of HMCs as biomimetic allostery of SPSAs for enhanced biomedical applications.
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Signal Transduction and Targeted Therapy
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2026
·Vol. 11
·期 1
·215
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IF 81.2
Guo Xiuping,Zheng Wensheng,Song Kaichao,Zhang Tingting,Luo Zhigang,Hui Zhouguang,Chen Qingbo,Qin Yuting,Sun Yanan,Hu Chujuan,Tian Xiaolian,Yang Sitong,Ren Ling,Yu Quanyong,Yu Haoyang,Li Bozhao,He Yingying,Li Yuanbin,Pan Mingyu,Che Yongsheng,Nie Guangjun,Jiang Jiandong,Wang Lulu
In triple-negative breast cancer (TNBC), chemotherapy-induced immunogenic cell death (ICD) often fails to trigger truly effective antitumor immunity. This failure primarily stems from the simultaneous release of damage-associated molecular patterns (DAMPs) and immunosuppressive prostaglandin E2 (PGE 2 ), creating an intrinsic NOT-AND signaling conflict. This barrier hinders efficient immune priming, a response rarely induced by conventional chemotherapy. To address this conflict while minimizing toxicity, R-Gem@Cel-PV, a spatiotemporally programmed nanovesicle, was designed to impose both spatial localization and sequential signal control within the tumor microenvironment. Following preferential accumulation in tumor tissue, enzymatic disassembly of the nanomedicine triggers the rapid release of celecoxib to suppress local PGE 2 signaling and alleviate immune suppression. Subsequently, the delayed activation of a phospholipid-gemcitabine prodrug induces DAMP-releasing cell death. This temporal decoupling—unachievable with free drug combinations—converts gemcitabine from a weak ICD inducer into a potent one. In TNBC models, R-Gem@Cel-PV boosted dendritic cell maturation, orchestrated a robust antitumor immune response, and significantly inhibited both primary tumor growth and metastasis. These findings demonstrate that resolving the immunosignal conflict through precise spatiotemporal control is essential for effective immune engagement in TNBC and offer a generalizable strategy for reprogramming the immune response to chemotherapy in immune-refractory tumors.
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 6
·429
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IF 5.4
Huang Shihao,Shen Hao,Ding Li,Yu Shaoning
Analytical platforms capable of rapid detection of foodborne pathogens with high sensitivity and localized specificity are indispensable not only for quality control protocols in the food industry but also broader applications in clinical diagnostics, public health surveillance, and environmental monitoring. Here, we engineered a novel fluorescently tagged magnetic nanoplatform for highly sensitive and specific detection of foodborne pathogens by leveraging an aptamer-functionalized covalent organic framework (COF) and integrating it with the rapid separation capabilities of magnetic nanoparticles to achieve significant signal amplification and target enrichment. Methicillin-resistant Staphylococcus aureus and Listeria monocytogenes were detected within 60 min after sample pretreatment with detection limits of 4 and 6 CFU/mL, respectively. Spiked recovery experiments in real food samples showed remarkable recovery (91.9%-106%), confirming potential for practical applications. Therefore, this work provides a novel and efficient COF-driven platform for the rapid detection of foodborne pathogens. Graphical abstract The alternative text for this image may have been generated using AI.
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APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
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2026
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IF 3.5
Awang Danzeng,La Zong,Baima Kangzhuo,Xie Hongjun,Wang Li,Liu Xinyao,Wang Yueying,Shi Yan,Zhao Yicheng,Gongga Lanzi
Hypoxia-related myocardial injury is characterized by oxidative stress, mitochondrial dysfunction, and apoptosis, ultimately resulting in impaired cardiac structure and function. Salidroside (SAL), a major bioactive component of Rhodiola, has been shown to have antioxidant and cardioprotective effects, but its role in hypoxia-related myocardial injury remains incompletely understood. In this study, we combined network pharmacology, molecular docking, and experimental validation to investigate the protective effect of SAL in CoCl 2 -induced hypoxia-mimetic models. In vitro, SAL improved cell viability, reduced ROS accumulation, restored mitochondrial membrane potential and ATP production, and attenuated apoptosis in CoCl 2 -treated H9C2 cells. In vivo, SAL alleviated electrocardiographic abnormalities, myocardial histopathological injury, cardiomyocyte hypertrophy, and associated lung and liver damage in CoCl 2 -treated rats. Mechanistically, SAL modulated the Akt/GSK-3β signaling axis under CoCl 2 -induced stress. Notably, Akt inhibition experiments revealed that SAL promotes protective GSK-3β phosphorylation and exerts its anti-apoptotic effects through a largely Akt-independent mechanism. Collectively, these findings indicate that SAL alleviates hypoxia-induced myocardial injury through the attenuation of oxidative stress, the preservation of mitochondrial function, the suppression of apoptosis, and the robust, Akt-independent regulation of GSK-3β. Graphical The alternative text for this image may have been generated using AI.
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Cancer Cell International
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2026
·Vol. 26
·期 1
·211
·
IF 7
Yan Ping,Luo Yunhai,Peng Dadi,Mou Tong,Lei Dengliang,Li Shanshan,Yu Huarong,Huang Zuotian,Wu Zhongjun
Background Hepatocellular carcinoma (HCC) is frequently associated with serious metabolic disorders, resulting in a bleak prognosis. Although ADH4 is implicated in the metabolism of fatty acids, its exact function in tumourigenesis is still unclear. Methods Our study initially examined proliferation potential in vitro and in vivo using various approaches, such as CCK8, EdU incorporation, colony formation assays, and a tumourigenicity assay in mice, which included orthotopic injection into the left liver lobe. Next, we conducted a quantitative analysis of oxylipins to investigate the correlation between ADH4 and lipid peroxidation in hepatoma cells. Additionally, we examined the intracellular ratio of NADP+/NADPH and measured the production of reactive oxygen species (ROS) and malondialdehyde (MDA) in other hepatoma cells. Furthermore, we employed mRNA sequencing to identify the downstream targets of ADH4 in hepatoma cells. Results The results indicate that there is a significant association between ADH4 levels and lipid peroxidation in hepatoma cells. It has been shown that there is a downregulation of ADH4 expression in hepatocellular carcinoma, and that ADH4 deficiency is a contributing factor in tumour progression and overall poor prognosis. Both gain- and loss-of-function studies have demonstrated that ADH4 has an anti-proliferative effect on hepatocellular carcinoma both in vitro and in vivo. Inhibition of ADH4 leads to the accumulation of oxylipin metabolites and an increase in the NADP+/NADPH ratio, ROS and MDA production, ultimately resulting in the activation of the KEAP1/NRF2 pathway and the nuclear translocation of NRF2. Furthermore, the results of mRNA sequencing indicate a close correlation between ADH4 expression and the cytokine-cytokine receptor pathway, with the strongest negative association found with CSF1 expression. This has been validated in other hepatoma cells and clinical patient samples. Flow cytometric analysis has confirmed ADH4’s ability to suppress CSF1-mediated polarization of M2-type macrophages in an NRF2 signaling-dependent manner. In conclusion, ADH4 plays a significant role in the regulation of macrophage polarization. Conclusion These findings suggest that downregulation of ADH4 may exert protumourigenic effects on hepatocellular carcinoma by increasing lipid peroxidation levels, NADP+/NADPH ratio, ROS and MDA levels, leading to activation of the KEAP1/NRF2 pathway, upregulation of CSF1 and M2-type polarisation of tumour-associated macrophages (TAMs), suggesting a potential therapeutic strategy for hepatocellular carcinoma.
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Nano-Micro Letters
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2026
·Vol. 18
·期 1
·386
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IF 38.5
Fan Xiaoming,Wu Peiyi,Jiao Yucong
Evolving Zn anodes with high areal capacity at elevated depths of discharge (DOD) is crucial for scalable aqueous battery, yet plagued by dendritic growth and parasitic reactions. Here, we constructed a polymer protective layer (PDMAG@Zn) comprising hydrophobic poly(N,N-dimethylacrylamide) (PDMAA) and zincophilic cationic guar gum (CGG) via an in situ strategy. The moderately hydrophobic property of PDMAA prevents the "Grotthuss" effect on Zn surface to inhibit parasitic reactions while synergistically accelerates Zn2+ desolvation behavior with a molecular lubrication mechanism. Additionally, the PDMAG layer guides Zn2+ deposition along (100) plane for rapid stripping/plating performance. Coupled with CGG-induced interfacial stabilization, the symmetrical batteries achieve ultralong cycling of 6580 h at 1 mA cm−2, 1 mAh cm−2, and 300 h at 1 mA cm−2, 15 mAh cm−2 with 91.5% DODWeight. Furthermore, the Zn||V2O5 full battery delivers a high capacity of 335 mAh g−1 at 1 A g−1, underscoring superior feasibility in practical applications.
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Nano-Micro Letters
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2026
·Vol. 18
·期 1
·390
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IF 38.5
Shi Shuo,Zhou Huiqun,Ming Yang,Zhou Xiong,Wu Hanbai,Ren Haipeng,Chow Lung,Su Jing,Chen Daming,Fei Bin,Razal Joselito M.,Wang Xungai
A bionic cooling skin with a hierarchical Janus nanofiber structure was fabricated by combining solvent welding technology with single-sided visible light-responsive metal–organic frameworks.
This unique design simultaneously realized effective passive cooling (~4 °C reduction under sunlight) through high mid-infrared emissivity and on-demand antibacterial activity via photocatalytic reactive oxygen species generation.
The bionic skin dressing closely mimics natural skin in mechanical properties and permeability while demonstrating superior healing performance for infected wound, with mechanistic insights supported by comprehensive gene expression analysis.
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Nature Communications
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2026
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IF 18.1
Li Gaofeng,Tan Jieke,Lin Changqing,Zhu Cheng,Du Yujiang,Li Zhou,Chen Shulin,Wei Xiaozhen,Xing Zhe,Wang Yuzhe,Lv Chunyu,Zhang Qixian,Liu Huicong,Li Weiping,Bai Yang,Yang Shihe,Lin Zedong,Liu Zhike,Chen Haining
Inorganic CsPbI 3 perovskite, known for its high chemical stability and near-ideal bandgap, offers a promising solution to the instability of organic-inorganic hybrid perovskites that limit perovskite solar cells (PSCs) longevity. However, the conventional intermediate phase (dimethylammonium lead iodide, DMAPbI 3 ) templating method suffers from inefficient phase conversion, hindering high-performance PSC development. To overcome this limitation, we engineered the crystallographic orientation of DMAPbI 3 to promote rapid volatilization of DMAI and accelerating the transformation. Through in situ anchoring of Pb 2+ -complexing groups (-F < -Cl < -SO 4 ) on TiO 2 substrates during chemical bath deposition, we direct the preferential in-plane growth of Pb-rich (100) planes of DMAPbI 3 , enhancing its [100] orientation. Crucially, stronger complexing groups yield higher orientation degrees, accelerating thermal conversion into highly oriented CsPbI 3 perovskite with higher purity and better optoelectronic properties. This strategy enables carbon-based, hole-transport-layer-free CsPbI 3 PSCs to achieve a record 20.72% efficiency (certified as 20.35%). Unencapsulated device retains > 85% of their initial efficiency after 1156 h of continuous maximum power point tracking under 1-sun illumination.
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npj Biofilms and Microbiomes
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2026
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IF 11.4
Huang Yue,Hu Yu,Zhao Yifei,Li Yuerui,Liu Yunkun,Wang Miao,Wang Qian,Hu Huan
Ulcerative colitis (UC) and periodontitis, both microbial dysbiosis-driven chronic inflammatory disorders, coexist and mutually exacerbate, but the causal mechanisms remain unclear. Using ligature-induced periodontitis plus DSS-colitis mice, we found UC doubles alveolar bone loss, heightens systemic inflammation, oxidative stress, and osteoclastogenesis. 16S rRNA and LC–MS metabolomics showed UC enriches oral pathogens, depletes gut Firmicutes, expands Bacteroides, and correlates with suppressed amino-acid/bile-acid biosynthesis. Fecal microbiota transplantation (FMT) from DSS donors into antibiotic-pretreated periodontitis-prone mice replicated aggravated bone loss, systemic inflammation, gut-barrier leakage, and Th17/Treg imbalance, while healthy-donor FMT protected. GC–MS revealed 35–60% reductions in acetate, propionate, and butyrate; keystone taxa Parabacteroides and Muribaculum inversely correlated with SCFAs and host inflammatory genes. Collectively, UC-driven gut dysbiosis is a transmissible causal factor that simultaneously remodels oral and intestinal biofilms, erodes epithelial barriers, and amplifies osteoclastic bone resorption. SCFAs-producing microbes or supplementation may be potential therapeutics for UC-associated periodontitis patients. The alternative text for this image may have been generated using AI.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Liu Zhenwei,Pan Jie,Tan Jiahui,Yang Wanqing,Shi Yuxin,Wei Yurong,Xu Minmin,Wang Jie
Persistent luminescence nanoparticles (PLNPs) have attracted significant attention in biosensing and bioimaging. However, the variety of PLNPs that can be directly synthesized via bottom-up approaches remains largely limited to ZnGa 2 O 4 :Cr, Zn 2 GeO 4 :Mn, and their analogs. Herein, we report new spinel-structured CaSc 2 O 4 :Tb (CSO) PLNPs synthesized via a straightforward one-step hydrothermal method. The morphology of CSO PLNPs can be precisely tuned from spindle-like to bipyramidal and rod-like structures by adjusting the pH values of the synthesis solution, which in turn directly modulates their persistent luminescence intensity and decay duration. The CSO PLNPs were further functionalized with an azo-bond-containing BHQ-1 quencher to construct CSO-BHQ nanoprobes for profiling bacterial extracellular metabolism by targeting azoreductase (AzoR) activity. As a key enzyme in extracellular bacterial metabolism, AzoR participates in critical processes including azo-antibiotic degradation and bacterial communication, and its secretion level serves as an indicator of metabolic activity. Detecting AzoR secretion across different bacterial growth phases shows that enzyme production peaked during the exponential growth phase, reflecting the most active stage of extracellular metabolism. Moreover, by assessing extracellular metabolic activity with the CSO-BHQ nanoprobes, we can also determine bacterial antibiotic susceptibility. For instance, S. aureus was found to be insensitive to ampicillin but highly susceptible to vancomycin, while E. coli showed the opposite sensitivity profile. This work not only introduces a new class of easily synthesized PLNPs but also highlights their promising utility in tracking bacterial metabolism and rapidly identifying antibiotic susceptibility. Graphical abstract
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Advanced Fiber Materials
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2026
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IF 22.6
Fang Lingtao,Liang Jiaheng,Zhang Chi,Wang Huimin,Song Xian,Chen Lixi,Zhang Yaokang,Zhou Zhihao,Li Peng,Zheng Zijian,Huang Qiyao
Fiber-shaped ionic conductors are ideal for bioelectronic interfaces due to their structural and functional similarities to biological tissues. However, achieving high mechanical strength, superior conductivity, and long-term environmental stability within a scalable fiber format remains a formidable challenge. Here, we report a design strategy to fabricate tough, robust, ionic-conductive and stable (TRIS) fibers via continuous UV-assisted spinning of a quaternary deep eutectic solvent. The core lies in the synergistic interplay between a highly dynamic hydrogen-bonding supramolecular network and dynamic carboxyl–zirconium coordination complexes. This molecular architecture enables TRIS fibers to simultaneously realize a high Young’s modulus (approximately 8.7 MPa) and excellent ionic conductivity (approximately 0.896 S/m). Furthermore, the fibers exhibit exceptional environmental stability, maintaining stable performance for over 1 year in ambient conditions. As a demonstration, TRIS fibers function as ionic cables that can transmit high-fidelity signals under strain (approximately 50%) and, notably, as artificial nerves to bridge a severed sciatic nerve in rats. The successful restoration of sensory and motor functions in vivo highlights the potential of TRIS fibers as functional neural replacements. This work provides a scalable and robust platform for the development of next-generation, tissue-like implantable bioelectronics. Graphical abstract
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