Biomaterials Science
·
2021
·Vol. 9
·期 22
·7591-7602
·
IF 6.843
Junlie Yao,Fang Zheng,Fang Yang,Chenyang Yao,Jie Xing,Zihou Li,Sijia Sun,Jia Chen,Xiawei Xu,Yi Cao,Norbert Hampp,Aiguo Wu
Photothermal therapy (PTT), as a promising antineoplastic therapeutic strategy, has been harnessed to restrain tumor growth through near-infrared (NIR) irradiation mediated thermal ablation. Nevertheless, its biological applications are hampered by thermal diffusion and up-regulated heat shock proteins (HSPs). Herein, a versatile nanotheranostic agent is developed via integrating Zn0.2Fe2.8O4 nanoparticles (NPs), polydopamine (PDA), and MnO2 NPs for T1/T2 dual-modal magnetic resonance (MR) imaging-guided and self-augmented PTT. The as-designed Zn0.2Fe2.8O4@PDA@MnO2 NPs adequately serve as a PTT agent to realize effective photothermal conversion and obtain local hyperthermia. Additionally, the Zn0.2Fe2.8O4@PDA@MnO2 NPs can significantly consume overexpressed glutathione (GSH) and generate Mn2+ in the tumor microenvironment (TME), thus destroying redox homeostasis and catalytically generating hydroxyl radicals (˙OH) for HSP suppression and PTT enhancement. Meanwhile, Mn2+ and Zn0.2Fe2.8O4 NPs significantly strengthen T1- and T2-weighted MR contrast for tumor imaging and PTT guidance. Hence, this study offers proof of concept for self-augmented PTT and T1/T2 dual-modal MR imaging for tumor elimination.
研究领域:
生物医学工程
·
纳米技术
·
癌症治疗
·
医学影像
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2024
·
IF 5.4
Nan Lv,Shaodong Zhai,Jun Xiong,Nan Hu,Xiang Guo,Zhida Liu,Ruiping Zhang
Pathological thrombus can cause serious acute diseases that present a significant threat to human health, such as myocardial infarction and stroke. Challenges remain in achieving effective thrombolysis and real-time monitoring of therapeutic effects while minimizing side effects. Herein,a multifunctional nanoplatform (TG-OPDEA@UK/MnO 2 -H1080) with enhanced thrombus-permeability was developed to monitor the therapeutic effect of antioxidant-thrombolysis by hydroxyl radical-responsive NIR-II fluorescence imaging. The polyzwitterion poly (oxidized N,N-Diethylaminoethyl methacrylate- co -n-butyl methacrylate) (OPDEA) was prepared as the matrix of nanoparticles to simultaneously loading urokinase (UK) and MnO 2 QDs, as well as NIR-II fluorescent molecule, H-1080. Subsequently, the fibrin targeted peptide CREKA was modified on the surface of the nanoparticles. OPDEA exhibits efficient loading capacity while endowing nanoparticles with the ability to effectively increased penetration depth of UK by 94.1 % into the thrombus, for extensive thrombolysis and fluorescence monitoring. The loaded UK exhibited good thrombolytic effect and greatly reduced the risk of bleeding by 82.6 %. TG-OPDEA@UK/MnO 2 -H1080 showed good thrombolytic efficacy and specific thrombus monitoring in the mouse carotid artery thrombosis model induced by ferric chloride (FeCl 3 ). This work prepares a nanoplatform for thrombolytic therapy and real-time efficacy assessment based on an independent externally forced thrombus penetration delivery strategy.
研究领域:
纳米技术
·
生物医学工程
·
诊疗学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Chunxue Zhang,Tingting Liu,Cuiyan Han,Cheng Yuan,Jiaqi Sun,Jing He,Xueting Yang,Xiaoyu Sui
Elevated oxidative stress, tissue hypoxia, imbalanced macrophage polarization, and impaired angiogenesis are major factors that contribute to the poor healing of diabetic wounds. Traditional wound dressings often lack specific functions and are insufficient for addressing the pathological complexity of diabetic wounds. Here, we developed a hydrogel dressing based on multiple synergistic effects. This dressing comprises manganese dioxide nanosheets (MnO 2 NSs) and recombinant human epidermal growth factor (rhEGF) loaded into a semi-interpenetrating hydrogel network with oxidized ginseng polysaccharide (OGPS), carboxymethyl chitosan (CMC), and sodium polyacrylate (PAAS) as the backbone materials, resulting in a CMC-OGPS/PAAS@MnO 2 NSs/rhEGF hydrogel. In vitro experiments revealed that OGPS and MnO 2 NSs synergistically scavenge intracellular reactive oxygen species (ROS) and that OGPS and rhEGF synergistically promote the proliferation and migration of L929 cells and tube formation by human umbilical vein endothelial cells (HUVECs). OGPS and MnO 2 NSs also exhibited synergistic bactericidal activity. In vivo experiments in mice revealed that this hydrogel can reduce inflammation in wound tissue; increase oxygenation levels; promote angiogenesis, epidermal growth and collagen deposition; and accelerate wound repair in diabetic patients. This study provides a promising solution for the application of ginseng polysaccharides.
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Shanshan Tao,Ruijia Hu,Xinyi Zhang,Chang Liu,Suqin Wang,Hongbo Li,Ruqin Yu
The residues of organophosphorus pesticides (OPs) in the environment and crops, resulting from irrational use will cause irreversible damage to the human nervous system by hindering acetylcholinesterase (AChE) activities. This study developed a novel proportional fluorescence sensing system based on UiO-66-NH 2 coated MnO 2 and Ampliflu Red (AR). In this sensor system, manganese dioxide nanosheets have both fluorescence quenching and catalytic functions. Based on the core mechanism of selective decomposition by reducing agents, it can respond to various OPs and enable multi-target detection of reducing biomolecules such as glutathione (GSH), cysteine (Cys), and ascorbic acid (AA). By means of principal component analysis (PCA), the sensor can effectively distinguish among GSH, Cys, and AA, achieving specific recognition of multiple targets. Under optimal conditions, the detection linear range for parathion is 1×10 -6 to 9×10 -1 mg/mL, with a detection limit as low as 0.33×10 -6 mg/mL; The linear ranges for GSH, Cys, and AA detection are 1–100 μM, 30–90 μM, and 1–50 μM, respectively, with detection limits of 0.33 μM, 10 μM, and 0.33 μM, respectively. This method exhibits high accuracy, facile operation, and favorable stability. It has been successfully implemented for the detection of tap water and 1% human serum samples. This makes the research findings more intuitive and clear. In addition, this research provides a feasible approach for developing diversified sensors based on functionalized metal-organic frameworks (MOFs), demonstrating strong potential for applications in environmental monitoring and bioanalysis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYST
·
2019
·Vol. 144
·期 6
·1988-1994
·
IF 4.019
Qi Wang,Yuan Zhang,Xiaodong Wang,Yuehuan Wu,Chuan Dong,Shaomin Shuang
A MnO2 nanoparticle (MnO2 NP)-mediated fluorescent turn-on probe for sensitively and selectively detecting glutathione (GSH) and recognizing cancer cells was established in this work. MnO2 NPs were synthesized simply and quickly through an in situ redox reaction by mixing bovine serum albumin (BSA) and KMnO4, in which BSA served the dual roles of template and reductant. It was found that the MnO2 NPs served as an effective energy acceptor and quenched the fluorescence intensity of carbon dots (CDs), owing to the fluorescence resonance energy transfer (FRET) process. Further, the addition of GSH triggered the decomposition of MnO2, breaking the FRET between MnO2 NPs and CDs and thus restoring the fluorescence intensity of CDs. Based on this mechanism, quantitative determination of GSH was performed. Under optimal conditions, a satisfactory linear range of 0.05–90 μM and limit of detection of 39 nM were obtained, and GSH content in human serum samples was detected. Moreover, taking advantage of the higher levels of GSH in cancer cells than in normal cells, the MnO2 NP-CD probe was applied to distinguish SMMC-7721 cancer cells from L02 normal cells. The FRET was interrupted by GSH in cancer cells, and strong fluorescence was observed. This work provides a facile approach for synthesizing MnO2 NPs, and this rapid, low-cost method with no need for reductants makes synthesis green and convenient. The MnO2 NP-mediated fluorescent turn-on response to GSH could improve the MnO2 nanomaterial-based biochemical analysis applications.
研究领域:
纳米医学
·
肿瘤学
·
生物分析化学
·
分子探针
·
转化医学
·
氧化还原生物学
✓ 已验证
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2020
·
IF 3.594
Xiaojing Guo,Yejing Huang,Wanxiang Yu,Xiao Yu,Xiufen Han,Haiyun Zhai
Multi-walled carbon nanotubes modified with iron oxide and manganese dioxide (MWCNTs-Fe 3 O 4 −MnO 2 ) was synthesized by using iron oxide (magnetic agent) and manganese dioxide (surface enhancer agent) to further approach in a magnetic solid-phase extraction (MSPE) coupled with high performance liquid chromatography (HPLC) method for the determination of bisphenol A (BPA) in plastic bottled drink samples. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray (EDX), Fourier-transform infrared spectroscopy (FTIR), vibrating sample magnetometer (VSM), and BET surface area measurement (BET) were used to characterized the materials. MWCNTs-Fe 3 O 4 MnO 2 are more effective for BPA adsorption than other materials which compared in this study. The binding performances of sorbent were evaluated by static and kinetic adsorption experiments. The data were well fitted to the Langmuir isotherm model and pseudo-second-order model, which the maximum adsorption capacity ( q max ) and the contact time of initial concentrations to achieve equilibrium were found to be 132.9 mg g −1 and 150 min, respectively. After adsorption, MWCNTs-Fe 3 O 4 −MnO 2 can be conveniently and quickly separated from the media by an external magnetic field, and adsorption-desorption capacity can remain at least 6 times of usage. Several parameters affecting the extraction efficiency were investigated. Under optimal conditions, the sorbent was successfully applied to MSPE followed by HPLC determination of BPA in real sample. The limit of detection (LOD) and limit of quantification (LOQ) values of MSPE-HPLC was 0.092 ng mL −1 and 0.167 ng mL −1 , respectively. Spiked recoveries ranged from 94.9 to 103.4% for four real samples, with relative standard deviations of less than 6.7%. It was concluded that the synthesized MWCNTs-Fe 3 O 4 −MnO 2 could be used as an efficient adsorbent for the determination of BPA in different plastic bottled drink samples.
研究领域:
环境科学
·
分析化学
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 7
·482
·
IF 5.4
Zhu Yun,Luo Tianshu,Niu Jingge,Cao Jie,Pang Yizhuo,Hou Xiaohong
A novel two-dimensional metal-organic framework (2D MOF), 2D Co-MOF@MnO 2 , with oxidase-like activity was successfully prepared via a solvothermal method, and its mimetic oxidase-like activity was investigated in detail. Its kinetic parameters K m and V max were determined to be 0.048 mM and 5.897 × 10 − 7 Ms − 1 , respectively. Taking advantage of the material’s ability to catalyze the oxidation of 3,3’,5,5’-tetramethylbenzidine (TMB) and the inhibitory effect of uric acid (UA) on this oxidase-like activity, we designed and constructed a portable colorimetric sensing device for the rapid detection of UA. This device enabled UA detection within 3 min at room temperature. The proposed system showed a linear response in the concentration range 5-200 µM with a detection limit of 4.98 µM, which was comparable to or even better than several previously reported colorimetric methods. This proof-of-concept study presented a novel and efficient approach that had potential for future point-of-care (POCT) applications for uric acid detection, and may offer new insights into early disease diagnosis, health monitoring, and biomedical research. Graphical abstract The alternative text for this image may have been generated using AI.
✓ 已验证
DOI
PubMed
高影响因子
MOLECULES
·
2019
·Vol. 24
·期 6
·1178
·
IF 3.06
Ziyu Ding,Peihong Deng,Yiyong Wu,Yaling Tian,Guangli Li,Jun Liu,Quanguo He
The nanohybrid of electrochemically-reduced graphene oxide (ERGO) nanosheets decorated with MnO2nanorods (MnO2NRs) was modified on the surface of a glassy carbon electrode (GCE). Controlled potential reduction was applied for the reduction of graphene oxide (GO). The characterization was performed by scanning electron microscopy, X-ray diffraction and cyclic voltammetry. Compared with the poor electrochemical response at bare GCE, a well-defined oxidation peak of sunset yellow (SY) was observed at the MnO2NRs-ERGO/GCE, which was attributed to the high accumulation efficiency as well as considerable electrocatalytic activity of ERGO and MnO2NRs on the electrode surface. The experimental parameters for SY detection were optimized in detail. Under the optimized experiment conditions, the MnO2NRs-ERGO/GCE showed good linear response to SY in concentration range of 0.01–2.0 μM, 2.0–10.0 μM and 10.0–100.0 μM with a detection limit of 2.0 nM. This developed method was applied for SY detection in soft drinks with satisfied detected results.
研究领域:
食品科学
·
分析化学
✓ 已验证
DOI
高影响因子
Small
·
2024
·Vol. 20
·期 35
·2310037
·
IF 13
Yudan Qian,Zhiming Zhou,Qingcheng Zhang,Huaping Zhao,Heng Chen,Jintong Han,Haiting Wan,Huile Jin,Shun Wang,Yong Lei
Highly concentrated “‘water-in-salt”’ (WIS) electrolytes are promising for high-performance energy storage devices due to their wide electrochemical stability window. However, the energy storage mechanism of MnO 2 in WIS electrolytes-based supercapacitors remains unclear. Herein, MnO 2 nanoflowers are successfully grown on mesoporous bowl-like carbon (MBC) particles to generate MnO 2 /MBC composites, which not only increase electroactive sites and inhibit the pulverization of MnO 2 particles during the fast charging/discharging processes, but also facilitate the electron transfer and ion diffusion within the whole electrode, resulting in significant enhancement of the electrochemical performance. An asymmetric supercapacitor, assembled with MnO 2 /MBC and activated carbon (AC) and using 21 m LiTFSI solution as the WIS electrolyte, delivers an ultrahigh energy density of 70.2 Wh kg −1 at 700 W kg −1 , and still retains 24.8 Wh kg −1 when the power density is increased to 28 kW kg −1 . The ex situ XRD, Raman, and XPS measurements reveal that a reversible reaction of MnO 2 + xLi + + xe − ↔ Li x MnO 2 takes place during charging and discharging. Therefore, the asymmetric MnO 2 /MBC//AC supercapacitor with LiTFSI electrolyte is actually a lithium-ion hybrid supercapacitor, which can greatly boost the energy density of the assembled device and expand the voltage window.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Qian Liu,Li Zhang,Xuna Liu,Zhongquan Zhong,Wei Deng,Ping Yang
Lithium ion-sieve with selective adsorption capacity is an important research direction in the field of recovering lithium from brine. The lithium ion-sieve precursor Li 1.6 Mn 1.6 O 4 was efficiently prepared using a combination of the hydrothermal method and solid-phase calcination. Subsequently, a highly adsorbent with high adsorption capacity was obtained through a process involving pickling and Li leaching. The impact of different preparation routes and conditions on both the intermediate product LiMnO 2 and the ion-sieve precursor Li 1.6 Mn 1.6 O 4 were investigated. Under conditions of 25 °C, pH 9, and an initial Li + concentration of 100 mg/L, the initial adsorption capacity and Mn dissolution loss are relatively optimal. After 10 cycles, the adsorption capacity stabilizes at 25–30 mg/g, However, Mn dissolution loss is unavoidable, it stabilizes between 2.0 % and 2.5 %. The selective adsorption of Li + remains effective even in the presence of Ca 2+ , Mg 2+ , Na + , and K + interference. Li desorption and Mn dissolution loss were investigated using density functional theory, Fukui function, electron orbital theory, and density of states. The introduction of H + during the pickling process induced structural modifications in the ion-sieve precursor Li 1.6 Mn 1.6 O 4 , leading to a decrease in Mn-Mn bonds, Mn-O bonds, and Li-O distances. Initially, Li + at each site of Li 1.6 Mn 1.6 O 4 had an equal probability of being replaced by H + . Subsequent desorption occurred far away from the desorption point. The loss of Mn 3+ in Li 1.6 Mn 1.6 O 4 resulted in an increased electrophilic attack index at the H + substitution site, and the 3d orbital electrons of Mn 3+ migrate to the 4d and 2p orbitals to seek stability.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Lumin Chen,Taoyi Shen,Zhongce Hu,Zhijiang Li,Hou-Yong Yu
Manganese dioxide (MnO 2 ) with high theoretical capacitance and natural abundance has attracted great attention but is still challenging for use in supercapacitors, due to the limited conductivity and lower electron and ion migration. Here, a facile in situ growth strategy is developed to prepare heterostructural graphitized cellulose nanocrystal (GCNC)/MnO 2 with unblocked conductive networks through a hydrothermal reaction. The GCNC with highly ordered graphitic carbon layers as conductive support framework solves the agglomeration problem of MnO 2 and increases effective specific surface areas in contact with electrolyte ions. Meanwhile, the stable connection of Mn O C covalent bonds enhances the interface bonding, which effectively reduces the contact resistance at the interface of heterostructural GCNC/MnO 2 and enhances the interface firmness. The resulting GCNC/MnO 2 electrode shows a remarkable specific capacitance of 528.2 F g −1 at 0.5 A g −1 . Furthermore, the symmetric supercapacitor based on GCNC/MnO 2 -15 mM exhibits high rate capability and excellent cycle stability of 100 % capacitance retention after 3000 cycles. This work provides a new path to designing high performance electrode material for sustainable energy technologies.
研究领域:
材料科学
·
能源技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers of Chemical Science and Engineering
·
2020
·Vol. 15
·期 3
·538-551
·
IF 3.552
Deng Xiaoyan,Wang Luxing,Xiu Qihui,Wang Ying,Han Hong,Dai Dongmei,Xu Yongji,Gao Hongtao,Liu Xien
In this work, an adsorbent, which we call MnPT, was prepared by combining MnO 2 , polyethylenimine and tannic acid, and exhibited efficient performance for Cu(II) and Cr(VI) removal from aqueous solution. The oxygen/nitrogen-containing functional groups on the surface of MnPT might increase the enrichment of metal ions by complexation. The maximum adsorption capacities of MnPT for Cu(II) and Cr(VI) were 121.5 and 790.2 mg·g −1 , respectively. The surface complexation formation model was used to elucidate the physicochemical interplay in the process of Cu(II) and Cr(VI) co-adsorption on MnPT. Electrostatic force, solvation action, adsorbate-adsorbate lateral interaction, and complexation were involved in the spontaneous adsorption process. Physical electrostatic action was dominant in the initial stage, whereas chemical action was the driving force leading to adsorption equilibrium. It should be noted that after adsorption on the surface of MnPT, Cr(VI) reacted with some reducing functional groups (hydroxylamine-NH 2 ) and was converted into Cr(III). The adsorption capacity declined by 12% after recycling five times. Understanding the adsorption mechanism might provide a technical basis for the procedural design of heavy metal adsorbents. This MnPT nanocomposite has been proven to be a low-cost, efficient, and promising adsorbent for removing heavy metal ions from wastewater.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）