ADVANCED MATERIALS
·
2025
·
IF 26.8
Si Sun,Fangzhen Tian,Huanhuan Qiao,Qi Xin,Xinxu Zhang,Nan Song,Yuxing Yan,Ling Liu,Yili Wang,Lijie Zhang,Ke Chen,Jiang Yang,Shu Zhang,Jianning Zhang,Yonghui Li,Hao Wang,Xiao-Dong Zhang
Type 2 diabetes mellitus is the most prevalent disease in the world, with one-tenth of the population suffering from the disease, and the most critical challenges are its complications that induce high disability and mortality rates. The state-of-the-art therapeutic agents can manage glucose but fail to prevent renal failure as well as neurodegeneration with immunosuppression. Herein, we developed a deep learning design strategy that exploits the ‘size-fitting effect’ to engineer an atomic-precision metal cluster for preventing diabetic complications by targeting metabolic abnormality and immunosuppression. The designed AuZn cluster achieves almost 100% α-amylase inhibition and 88% α-glucosidase inhibition, resulting in the normalized glycated hemoglobin and sustained glucose control. The intrinsic redox properties reduce oxidative stress damage, promoting β-cell regeneration and metabolic stress alleviation. Consequently, the renal function, the most prevalent complications, shows that glomerular filtration can be restored to normal levels without urinary protein, while the clinical dulaglutide is not show any improvement. The key marker during early neurocognitive disorders, the amyloid precursor protein (APP) induced by complications, can be effectively suppressed, and diabetes induced organelle degeneration in neurons can be restored.
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产品关联
DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2025
·
IF 4.8
Fei Jiang,Zhiming Dong,Xiaoli Lou,Zhuonan Zhang,Li Shuai,Chengke Zhao
Secondary benzyl alcohols (α-OH) in lignin β-O-4 linkages are reactive sites that can trigger undesirable condensation reactions during lignin valorization processes. The selective oxidation of α-OH groups can effectively inhibit lignin condensation reactions, thereby promoting lignin depolymerization. Meanwhile, this approach increases the functionalities, which is beneficial for the design of lignin-derived functional materials. In this study, we report a chemoselective oxidation method using 2-iodoxybenzoic acid (IBX) to selectively convert α-OH groups into ketones. The reaction proceeds under ambient conditions with green DMSO as the sole solvent. Oxidation of β–O–4 model compound (veratrylglycerol-β-guaiacyl ether, VG) revealed exceptional selectivity of this oxidation process, achieving 92% substrate conversion with 90% yield of the corresponding α-ketone product after 48 h. When applied to cellulolytic enzyme lignin, this protocol significantly increased the α-ketone content from 1.2% to 20.5% (relative to total interunit linkages), as identified and quantified by 2D HSQC NMR. The straightforward α-OH oxidation protocol demonstrates significant potential for precise lignin structure modification and rational design of lignin-derived functional materials in sustainable polymer systems.
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DOI
PubMed
高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
·
2014
·Vol. 41
·期 8
·5809-5819
·
IF 1.54
Zhao Bing,Jiang Lili,Liu Zhuo,Deng Qigang,Wang Liyan,Song Bo,Gao Yan
A microwave-assisted, convenient, efficient, and catalyst-free procedure is described for the synthesis of 1,3-diphenyl-3-(pyridin-2-ylamino)propan-1-one derivatives by Michael addition of 2-aminopyridine to the chalcones. Short reaction times, simple reaction, easy of product isolation, high yields, and clean work-up are the advantages of this method.
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DOI
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2024
·Vol. 107
·期 6
·4242-4251
·
IF 3.5
Shuya Wang,Wenzhi Sun,Tingting Zhao,Chunqing Fu,Xiaoyan Fu,Hongwu Zhang
In this paper, X-ray-activated super long persistent ultraviolet A luminescence from Ca 3 (PO 4 ) 2 : Ce 3+ has been observed. The crystal structure analysis has shown that the as-prepared samples are pure β-Ca 3 (PO 4 ) 2 phases with rhombohedral structure and R 3 c space group. The photoluminescent spectra of the samples all consist of a broad band in 340–400 nm UVA1 region, which is assigned to the 5d 1 –4f 1 electronic transition of Ce 3+ ions. More important, under the 3 min X-ray irradiation, Ca 3 (PO 4 ) 2 : Ce 3+ show super long persistent luminescence in the UVA1 region, which can persist for more than 16 h. And its afterglow intensity after 16 h decay is still 4.10 times stronger of the back ground intensity. Furthermore, only 10 s X-ray irradiation can induce excellent long persistent UVA luminescence of Ca 3 (PO 4 ) 2 : 0.08Ce 3+ , which can persist for more than 5 h and afterglow emission intensity is about 3.03 times of the background intensity. The trap analysis has confirmed that the different X-ray irradiation time do not create new traps and there is the same trap with 0.75 eV trap depth existing even under the extremely low X-ray dose (10 s X-ray irradiation). Furthermore, under 10 s X-ray irradiation, the thermoluminescence (TL) intensity of Ca 3 (PO 4 ) 2 : 0.08Ce 3+ still reaches 0.32 times of the initial TL intensity even after 120 min, which thus leads to the super long persistent luminescence. Thus, the large amounts of trapped electrons induced by the high energy X-ray irradiation are the principal cause for super long persistent UVA luminescence of Ca 3 (PO 4 ) 2 : Ce 3+ .
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高影响因子
Soft Matter
·
2021
·Vol. 17
·期 12
·3494-3502
·
IF 3.679
Wenchang Zhuang,Chunhua Zhao,Yue Pan,Qintang Li
As tailorable solvents, the physiochemical properties of ionic liquids can be tuned by the structure of ions. Herein, we investigate the structural effects of ILs on the self-assembly of surfactants. It has been confirmed that the cationic surfactant 1-hexadecyl-3-methylimidazolium bromide (C16mimBr) can self-assemble into micellar and lamellar lyotropic liquid crystal phases in the aprotic ionic liquid (AIL) 1-ethyl-3-methylimidazolium tetrafluoroborate ([Emim]BF4). In this work, we explore the aggregation behaviours in AILs with different alkyl chains on the imidazolium group, i.e., 1-propyl-3-methylimidazolium tetrafluoroborate ([Pmim]BF4), 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim]BF4), 1-hexyl-3-methylimidazolium tetrafluoroborate ([Hmim]BF4) and 1-octyl-3-methylimidazolium tetrafluoroborate ([Omim]BF4). With the increase of the cation chain length, AILs have better solubility of the solvophobic part of the surfactants and hence a weaker driving force for self-assembly. Therefore, the critical micellization concentration of C16mimBr in AILs increases as confirmed by the surface tension and small angle X-ray scattering characterizations. More interesting things happen to the phase behaviours. Besides the micellar and lamellar lyotropic liquid crystal phases, a hexagonal lyotropic liquid crystal phase is formed in [Pmim]BF4 while hexagonal and bicontinuous cubic lyotropic liquid crystal phases are formed in [Bmim]BF4, [Hmim]BF4 and [Omim]BF4. It is surprising to observe richer phase behaviours in solvents of lower cohesive energy. The detailed structural information of various aggregates has been obtained by small-angle X-ray scattering. It is demonstrated that AILs work as not only solvents but also co-surfactants.
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Zhenghua Zhang,Jiugang Hu,Yang Hu,Hongmei Wang,Huiping Hu
Ni-rich LiNi x Co y Mn 1−x−y O 2 /graphite batteries with Ni ≥ 0.8 have aroused great interest in high-energy–density Li-ion batteries. However, their practical applications still face huge challenges owing to severe capacity fading on unstable cathodic solid electrolyte interfaces (SEI). Herein, we propose an advanced electrolyte additive , tri(2-furyl)phosphine (FuP), to induce the simultaneous formation of robust SEI films on cathode and anode surfaces. This interphase can significantly improve the cyclability of commercial LiNi 0.8 Co 0.1 Mn 0.1 O 2 /graphite pouch cells at 45 °C and reduce cell impedance during cycling. The capacity retention rate of the cells with the FuP-based electrolyte can reach 90 % after 600 cycles, which is considerably better than that of baseline batteries (70 %). Mechanistic studies indicate that FuP suppresses the formation of fragile Li 2 CO 3 to generate more stable LiF, Li x PO y F z , and additional organic phosphorus species on the electrode surface, thereby preventing cation disorder and irreversible phase transitions. These results provide a facile and efficient strategy for enhancing the performance of Ni-rich Li-ion batteries.
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高影响因子
SYNTHESIS-STUTTGART
·
2025
·Vol. 57
·期 14
·2241-2251
·
IF 2.3
Yilun Song,Deyang Liu,Shunxi Dong,Xiaoming Feng
A highly enantioselective alkoxylation reaction of 3-bromo-3-substituted 2-oxindoles with alcohols was achieved by a chiral Ni(II)/N,N′-dioxide complex. This strategy provided an efficient route to various enantioenriched 3-alkyl 3-alkyloxy-2-oxindoles with good yield and enantiomeric ratio (40 examples, up to 99% yield, 95:5 er). Moreover, phenol and benzenethiol were also compatible with the reaction conditions. The gram-scale synthesis of an optically active product and its further transformation into CPC-1 analogue demonstrated the potential utility of the method. In addition, a catalytic cycle as well as a possible working mode was provided to understand the enantioselectivity of the reaction.
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高影响因子
GREEN CHEMISTRY
·
2024
·Vol. 26
·期 20
·10383-10389
·
IF 9.3
Haibo Zhu,Ting Zhong,Liu Yang,Yajing Shen,Qiangwen Fan,Zhanggao Le,Zongbo Xie
The photocatalytic activation of oxygen molecules (O2) is an environmentally friendly and sustainable alternative to substituted benzofuran-3(2H)-one synthesis. Herein, lead-free Cs2AgBiBr6 nanocrystals were used to activate O2 efficiently and selectively for the photocatalytic transformation of 4-hydroxycoumarins to functional 2-hydroxy-benzofuran-3(2H)-ones under an air atmosphere. Polyfunctionalized benzofuran-3(2H)-ones with a quaternary carbon center can be selectively obtained in moderate to good yields at room temperature via one-pot synthesis. Perovskite crystal structures have significant influence on photocatalytic activity due to the different charge separation abilities. The reaction mechanism was further investigated to confirm the contribution of reactive oxygen species (ROS).
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高影响因子
Journal of Materials Chemistry A
·
2016
·Vol. 4
·期 29
·11430-11438
·
IF 8.262
Hua Tian,Lin Wang,Yang Jiang,Lin Zhang,Yan Li,Li Hou,Cunqi Wu,Faming Gao
Graphene has great potential to significantly enhance the electrochemical activity of redox-active materials for supercapacitors. However, the agglomeration of graphene sheets remains a critical challenge to excellent energy storage performance of hybrid composites supported by graphene. Herein, a facile hydrothermal approach for the synthesis of porous Ni2CO3(OH)2/functionalized graphene (NCB/FGN) composites is developed. To improve the dispersion properties of graphene, sulfonated salicylic acid serving as a functionalized composition is covalently anchored to the surface of functionalized graphene. The systematic investigation indicates that the presence of functionalized graphene plays a crucial role in establishing the porous structure of hybrid composites. Compared to reduced graphene oxide (rGO), functionalized graphene is more beneficial to accommodate the expansion of the surface area and the reduction of the pore length in hybrid composites. The detailed electrochemical characterization demonstrates that the unique porous structure of NCB/FGN composites encompasses the great capability of rapid kinetic diffusion of active ions in electrolytes during the electrochemical reaction. The specific capacitance of NCB/FGN composites is 1508 F g−1 at a current density of 1 A g−1, higher than 1258 F g−1 for NCB/rGO composites and 1039 F g−1 for pristine NCB. After 3000 charge–discharge cycles at a current density of 10 A g−1, the specific capacitance of NCB/FGN composites still approaches their initial capacitance.
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DOI
高影响因子
MINERALS ENGINEERING
·
2019
·
IF 3.315
Cheng Liu,Wencai Zhang,Hongqiang Li
In this study, 2-phosphonobutane-1,2,4-tricarboxylic acid (PBTCA) was introduced as a depressant for the flotation separation of apatite from calcite. The micro-flotation test results showed that good floatability of both apatite and calcite were obtained at around pH 8.5 when using sodium oleate (NaOl) as collector. Mixed minerals flotation test results showed that an efficient separation of apatite from calcite was achieved using PBTCA as depressant, which presented a selective depression for the calcite. Zeta potential measurements indicated that the addition of PBTCA prior to NaOl did not interfere the interaction between NaOl and apatite while it decreased NaOl adsorption on calcite surface.
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DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Runhua Gao,Handing Liu,Bowen Fu,Shuyang Li,Ziyao Long,Dalin Sun,Yun Song
Germanium-based materials possess high theoretical capacity of approximately 1000 mAh·g −1 , nevertheless, the practical electrochemical performance is severely hampered by poor cyclability due to volumetric expansion of Ge upon cycling. Herein, novel hydrangea-like CoGeO 2 (OH) 2 constructed by 2D nanoplates has been facilely synthesized with the assistance of ethylene glycol and further applied to anode materials for lithium ion storage. The hydrangea-like CoGeO 2 (OH) 2 anode exhibits an enhanced specific capacity of 1174 mAh·g −1 at a current density of 0.5 A g −1 after 100 cycles. Such outstanding electrochemical performance could be accredited to the rationally designed hydrangea-like structure, which can relieve the interval stress aroused by lithiation/de-lithiation, shorten the pathway of electron/ion transportation and take advantage of the pseudocapacitive nature of two dimensional nanosheets that could improve the reaction kinetics and endow the material with remarkable rate capability. Moreover, the inherent Co-bonded hydroxyl groups facilitate the pseudocapacitive effect, and Ge-based component contributes to the capacity. These advantages help CoGeO 2 (OH) 2 hydrangeas gain a competitive edge over other candidates of anode materials for lithium-ion batteries.
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高影响因子
JOURNAL OF CHEMICAL CRYSTALLOGRAPHY
·
2016
·Vol. 46
·期 3
·128-136
·
IF 0.572
Peng Jun-Ling,Gao Ming-Juan,Wu Jian-Zhong,Ou Yong-Cong,Yu Ying
Two IIB group metal complexes based on 2-hydroxypyrimidine-4,6-dicarboxylic acid (H 3 L), formulated as {[Zn 3 L 2 (H 2 O) 4 ]·2H 2 O}
n
( 1 ) and {[Cd 3 L 2 (H 2 O) 6 ]·H 2 O}
n
( 2 ), have been synthesized solvothermally. Structural studies reveal that 1 and 2 are two- and one-dimensional polymeric networks, respectively, both of which are expanded to three-dimensional supramolecular structures by hydrogen bonds. The L 3− ligand takes the same μ 4 κ 5 ligation mode in both complexes. The Zn(II) coordination polyhedron in 1 is either octahedral or square pyramidal, but the Cd(II) atoms in 2 adopt two different octahedral polyhedra. Both 1 and 2 display remarkably strengthened fluorescence compared to the free H 3 L, and 1 emits much stronger than 2 , consistent with the structural features. Graphical Zn(II) and Cd(II) coordination polymers of 2-hydroxypyrimidine-4,6-dicarboxylic acid with 2D and 1D dimensions respectively exhibit different photoluminescence behavior.
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DOI
高影响因子
危险品化学品经营许可证（带存储）