Nature Communications
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2026
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IF 18.1
Han Zilong,Lu Yuchen,Yang Hua,Mu Yan,Li Siming,Wang Jiahao,Yang Wei,Qu Shaoxing
Water in hydrogels has often been overlooked or deemed detrimental to the mechanical properties of hydrogels due to the plasticizing effect of water, which weakens interchain interactions and accelerates crack propagation. Here, we propose a slow-water strategy that imparts enhanced fracture resistance to hydrogels. By converting free water into slowly migrating intermediate water, we suppress excess chain mobility by reducing the free volume around polymer chains, thereby enhancing interchain interactions and substantially extending the load-transfer length. Notably, even with only 13% polymer content and without additional network design, the hydrogels achieve orders-of-magnitude improvements in fracture toughness and fatigue threshold solely through medium design, and these enhancements are demonstrated to be dominated by the intermediate water. The strategy demonstrates versatility, providing insights into the role of intermediate water in biological systems and enabling innovative approaches to reinforcing biomimetic materials under complex stress conditions.
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高影响因子
Nature Communications
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2026
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IF 18.1
Tong Zebin,Yuan Rujing,Wu Xiangwei,Cai Hongyi,Xu Ziyu,Liu Lei,Ai Huasong
The giant E2–E3 chimera BIRC6 specifically engages ubiquitin-activating E1 enzyme UBA6, but not UBA1, enabling UBA6 to transfer activated ubiquitin to BIRC6, which then ubiquitinates downstream substrates such as caspases to regulate apoptosis. However, the molecular mechanism that underlies UBA6-mediated specific engagement of BIRC6 remains elusive. Here we use a Ub Dha probe to trap the transient E1–E2 transthioesterification intermediate and determine cryo-EM structures of singly and doubly loaded UBA6-BIRC6 UBC complexes at 3.3 and 3.4 Å resolution. Structural analysis reveals that an insertion loop (residues 4649–4653) in BIRC6 and the gate helix of UBA6 play a key role in the specific BIRC6-UBA6 pairing. Unlike UBA1, UBA6 avoids steric clash through a ~ 30° rotation and a 19 Å displacement of its gate helix, creating a compatible cavity for the insertion loop. Biochemical validation confirms that truncation of the BIRC6 insertion loop rescues UBA1‑mediated charging, and swapping the UBA6 gate helix into UBA1 confers activity toward BIRC6 UBC . Our study provides structural insights into E1–E2 pairing specificity and advances the mechanistic understanding of apoptotic signaling.
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高影响因子
Nature Communications
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2026
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IF 18.1
Xie Han,Chen Tucan,Yan Peiyu,Fu Yuqi,Lei Mengcheng,Liu Yuanyuan,Zhao Xudong,Du Wei,Feng Xiaojun,Liu Xin,Li Yiwei,Chen Peng,Liu Bi-Feng
Extracellular vesicles (EVs) are promising non-invasive biomarkers for early cancer detection, yet clinical translation is limited by membrane fouling during isolation and vesicle aggregation during single-vesicle imaging. Here, iEVIP (intelligent extracellular vesicle isolation and profiling), an integrated dual-inspired platform, combines intelligent pulsatile filtration, blood-smear-inspired nanoscale organization and machine-learning-based classification. Real-time transmembrane-pressure monitoring triggers back-aspiration pulses upon membrane fouling, promoting membrane regeneration and stable EV recovery from plasma. A wettability-assisted nano-smear array reduces aggregation and fluorescence overlap, enabling high-throughput multiplexed single-EV imaging. iEVIP achieves 95.32% classification accuracy for cell-line-derived EVs and up to 80.37% in exploratory clinical cohorts using random forest algorithm. By bridging macroscopic engineering principles with nanoscale bioanalysis, iEVIP provides a scalable framework for high-throughput single-EV analysis and exploratory clinical sample classification. However, the limited cohort size and absence of cross-center external validation constrain generalizability, and larger independent cohorts are needed to establish diagnostic robustness and clinical applicability.
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高影响因子
MOLECULAR BIOLOGY REPORTS
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2026
·Vol. 53
·期 1
·1444
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IF 3.2
He Yalun,Ding Jie,Li Yangshuo,Sun Ji,Wei Cuiping,Sun Na,Jiang Runnan,Zhao Ziming,Liang Xiaolan,Chen Yiming,Cheng Wen,Zhang Litai,Song Di,Sun Shuai,Yu Chaoqin
Background Endometriosis (EMS) is an oestrogen-dependent chronic inflammatory disease that primarily manifests as chronic pelvic pain and infertility. EMS-associated infertility is closely linked to diminished ovarian function and oocyte quality, with the aberrant function of granulosa cells (GCs). Cellular senescence has a nonnegligible effect on female fertility. GCs in EMS patients may undergo senescence, subsequently compromising their nutritional support to oocytes and impairing ovarian function, ultimately contributing to infertility. Icaritin (Ica) possesses various biological activities including anti-tumour, anti-inflammatory, anti-oxidation and anti-aging. Methods Follicular fluid (FF) was collected from normal control females and EMS patients. GCs were extracted from FF for RNA sequencing and bioinformatic analysis. NADH: ubiquinone oxidoreductase core subunit S8 (NDUFS8)-knockdown KGN cells were established using shRNA-mediated lentiviral transduction. Pro-oxidants and oxidation scavengers were employed to modulate reactive oxygen species (ROS) levels. Network pharmacology was employed to analyse potential mechanisms of Ica in treating EMS. Ica was employed to intervene EMS-FF-treated KGN cells and EMS mice. Results Ica significantly reduced degrees of peritoneal adhesions, decreased quantities and volumes of ectopic lesions and improved reproductive capacity in EMS mice. Moreover, Ica may inhibit ovarian GC senescence and improve ovarian function in EMS mice by regulating NDUFS8/ROS/P53/P21 axis. In vitro experiments demonstrated that Ica may inhibit EMS-FF-induced KGN cell senescence by regulating NDUFS8/ROS/P53/P21 axis. Conclusions These findings identify Ica as a GC senescence-inhibiting agent with therapeutic potential in EMS-associated infertility.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Liang Lei,Aixiang Wang,Liping Dong,Tao Wu,Wenjuan He,Yonghui Yang,Jing Li,Xiaobin Bi,Yuan Cai,Xinlei Guan,Xiaoqiang Zhu
The use of titanium dioxide (TiO 2 ) as a food additive has persistently elicited concerns about its potential toxicity, primarily attributed to the significant presence of nanoparticles. Studies have recently demonstrated that nano- or micro-sized food-grade TiO 2 (fg-TiO 2 ) particles can disrupt gut microbial balance and weaken the intestinal barrier; however, the underlying mechanisms remain poorly understood. Furthermore, research on dietary interventions for repairing fg-TiO 2 -induced intestinal injury is limited. This study delved into the role of the interactions among gut microbes, indole-3-lactic acid (ILA) and mucin sulfation in fg-TiO 2 -induced intestinal mucosal barrier damage through multi-omics analysis, and revealed the protective effects of quercetin. Prolonged oral administration of fg-TiO 2 at doses pertinent to human exposure resulted in notable intestinal inflammation and mucosal barrier damage through diminishing mucin sulfation. Further analysis demonstrated that fg-TiO 2 caused significant gut microbiota dysbiosis and metabolite changes. It was found that Lactobacillus and its metabolite ILA, an aryl hydrocarbon receptor (AHR) agonist, was significantly downregulated following oral ingestion of fg-TiO 2 , which decreased the activation of AHR and ultimately led to a loss in mucin sulfation in colon tissues. Notably, experiments involving fecal microbiota transplantation (FMT) and ILA supplementation indicated gut microbial shifts and the consequent decrease in colonic ILA levels were accountable for the detrimental effects of fg-TiO 2 on mucin sulfation and intestinal barrier integrity. Moreover, this study found that dietary intervention with quercetin could effectively reverse the damage to the intestinal mucosal barrier induced by fg-TiO 2 through targeting gut microbiota-ILA-mucin sulfation axis. This research uncovered the adverse impacts of fg-TiO 2 on gut homeostasis and indicates the potential of quercetin to combat the intestinal toxicity of fg-TiO 2 . These findings enhanced our comprehension of the safety profile of fg-TiO 2 and proposed a nutritional approach to mitigate the health risks associated with fg-TiO 2 exposure.
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PubMed
高影响因子
Nature Communications
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2026
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IF 18.1
Huang Jun-Dan,Tan Xiao,Liu Jun,Zhao Bo,Li Hong-Qiang,Ren Ying-Yi,Tian Rui,Xiong Yisi,Li Chong,Wang Ming-Kui,Xiang Shi-Li,Zhu Ming-Qiang
We propose an exposure dose-dependent multi-tone photolithographic strategy based on competing photoacid-induced crosslinking and degradation within a single homopolymer system. Poly(2,3-dihydrofuran) (PDHF), synthesized via ring-opening metathesis polymerization, integrates acid-triggered inter-chain cationic crosslinking and main-chain acid-catalyzed scission through enol ether moieties, enabling negative-tone, positive-tone, and edge-retained patterning without post-exposure baking. At low exposure doses, crosslinking dominates to generate negative-tone features, whereas high doses induce degradation to produce positive-tone patterns. Unlike conventional chemically amplified resists, the developed patterns consist of crosslinked networks, suppressing photoacid migration and reducing pattern blurring. This work demonstrates a dose-dependent multi-tone lithographic strategy based on photoacid-induced crosslinking and degradation within a single polymer system, offering insights into exposure-controlled pattern formation.
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高影响因子
BMC Pregnancy and Childbirth
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2026
·Vol. 26
·期 1
·363
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IF 3.1
Xie Xinping,Yan Jianying,Chen Xiaoyun,He Lidan,Wu Jianbo,Lu Lin
Background Insulin resistance (IR) is a pivotal determinant in the pathophysiological processes underlying gestational diabetes mellitus (GDM). Angiopoietin-like protein 8 (ANGPTL8) exhibits an ambiguous influence on glucose metabolism in the onset and progression of GDM. However, the functions of ANGPTL8 in the metabolic profiles of insulin-resistant (IR) HepG2 cells, glucose tolerance in GDM mice, and the possible underlying mechanisms require further exploration. Methods ANGPTL8 knockout and over-expressing HepG2 cell lines were established. Glucose uptake capacity in three clones (wild-type, ANGPTL8 knockout, and over-expressing) of insulin-resistant HepG2 cells was detected. Proteomic analysis of the IR HepG2 cells identified a cluster of relevant signaling pathways, and the effect of ANGPTL8 on metabolomic changes was evaluated. The GDM model was induced by a high-fat diet (HFD) and intraperitoneal injection of Streptozotocin (STZ) in pregnant mice. An oral glucose tolerance test (OGTT) was performed in both GDM mice and ANGPTL8 over-expressing GDM mice. Results The PI3K/Akt signaling cascade was stimulated by insulin resistance, and this activation could be effectively suppressed by inhibitors targeting PI3K, Akt, and GSK-3β. HepG2 cells over-expressing ANGPTL8 and exposed to high insulin concentrations demonstrated a marked enhancement in glucose uptake capacity, as opposed to their wild-type counterparts or ANGPTL8 knockout cells under IR conditions. The most substantial down-regulation was observed in lactate and branched-chain amino acids (BCAAs), which exhibited a positive correlation with IR. Promoted translation of ANGPTL8 was found in the liver, pancreas, and placental tissues of GDM mice. Significantly better glucose tolerance was observed in GDM mice transfected with m-ANGPTL8 compared with those that were not. Furthermore, the activation of Akt was observed in the primary hepatocytes of ANGPTL8 over-expressing GDM mice. Conclusion Over-expression of ANGPTL8 may increase glucose uptake capacity and influence the metabolic profiles in IR HepG2 cells, enhancing the insulin-mediated activation of the PI3K/Akt/GSK-3β pathway. ANGPTL8 may improve glucose tolerance in GDM mice. These findings might contribute to a new understanding of the roles of ANGPTL8 in glucose metabolism during the onset and progression of insulin resistance, providing novel insights for the clinical therapy of GDM.
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高影响因子
Advanced Composites and Hybrid Materials
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2026
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IF 15.5
Yin Weimin,Li Yang,Chen Shiyu,Zhi Hui,Chang Jiao,Chen Nana,Yang Zichen,Xiao Yaping,Li Yan,Li Yongyong,Ma Bin,Dong Haiqing
Ferroptosis-based cancer immunotherapy is often limited by insufficient intracellular iron and inherent antioxidant defense. Inspired by heme oxygenase 1 (HMOX1), which catalyzes heme to release endogenous Fe 2+ , and informed by bioinformatics hints indicating a potential correlation between hypoxia-inducible factor-1α (HIF-1α) and HMOX1, as well as the critical role of glutaminase activity in redox metabolism. We rationally designed a hypoxia nanoalleviator (MPCC) co-loaded CaO 2 and the glutaminase inhibitor C968 onto mesoporous polydopamine nanocarriers. Under acidic condition, CaO 2 can generate O 2 and H 2 O 2 . The alleviation of hypoxia by the generated O₂ upregulates HMOX1 expression, which subsequently catalyzes heme degradation into Fe 2+ while simultaneously downregulating the iron exporter SLC40A1. This dual action disrupts iron homeostasis and promotes intracellular Fe 2+ accumulation. The accumulated Fe 2+ reacts with H 2 O 2 via a Fenton-like reaction, producing ROS to induce ferroptosis. Concurrently, hypoxia alleviation reduces HIF-1α expression, and thereby inhibiting glutamate transporter SLC1A1 expression, combining with glutaminase inhibitor C968, dual suppressing glutathione production to disrupt redox metabolism, causing ROS storms, thereby robustly enhancing ferroptosis. Enhanced ferroptosis effectively triggers immunogenic cell death, thereby activating T-cell immune responses and potently suppressing tumor growth and metastasis.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
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2026
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IF 4.4
Yuxuan Huang,Hongwei Lu,Shijia Yang,Weitao Su
High dielectric constant and high breakdown strength of nanodielectrics are difficult to achieve simultaneously, which is a challenge that must be faced in the current research, and a single-scale control strategy is difficult to solve the current problem. This study introduced hexafluorobutyl methacrylate (HFBMA) as a crosslinking modifier to prepare HFBMA/PVDF composite films by UV in situ crosslinking strategy. Through the study of multiscale control strategy, it was found that the FTIR results support the occurrence of UV-induced crosslinking, which is likely associated with the formation of a crosslinked network that restricts polymer-chain motion under high electric fields, inhibits the migration of molecular segments, significantly reduces the free-volume defects, and significantly increases the breakdown strength to 587.88 MV/m, which is 150% of PVDF (391.33 MV/m). The fluorinated side groups in HFBMA may contribute to deeper trapping states and charge-blocking effects because of their strong electronegativity, which is consistent with suppressed carrier migration and reduced space-charge injection, cutting conductivity loss and lowering the leakage current to 5.46 × 10 −7 A/cm 2 —one order of magnitude below that of pure PVDF. As a result, the energy storage density reaches 7.46 J/cm 3 , nearly double the value of PVDF. Graphical abstract
The alternative text for this image may have been generated using AI.
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高影响因子
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
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2026
·Vol. 41
·期 2
·346-352
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IF 1.4
Zheng Chenxi,Chen Cheng,Liao Jun,Zhang Haining
Silica nanoparticles-stabilized cobalt and nitrogen-doped carbon materials were synthesized through pyrolysis of metal-organic-framework of ZIF-67 supported by silica nanoparticles. The experimental results reveal that the introduction of the silica nanoparticles can stabilize the microstructure of the derived Co-N-C materials, which in turn exhibits the promising electrocatalytic activity towards both oxygen reduction and oxygen evolution reactions. The optimized sample exhibits a better oxygen reduction activity than commercial Pt/C catalyst as confirmed by the positive shift of half-wave potential by 20 mV while it has a low overpotential of 273 mV for oxygen evolution reactions with the retained performance over 80% after 25,000 s of continuous operation. It is demonstrated that the introduction of support frame might be an effective way to improve the activity and stability of metal-organic-framework derived electrocatalyst with stabilized microstructure.
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高影响因子
Nature Communications
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2026
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IF 18.1
Cao Fengliang,Feng Wenting,Kong Debin,Hai Xiao,Zhao Qingshan,Wu Mingbo,Xue Song,Zhi Linjie
Electrocatalytic acetylene semi-hydrogenation is an attractive route for ethylene production, but competing side reactions like hydrogen evolution, over-hydrogenation, and C–C coupling severely compromise its industrial viability. Here, we present a carbon-nanotube-supported metal phthalocyanine platform, MPc/XCNT (M = Cu, Co, Ni, Fe; X = O, N, S), to investigate the roles of metal centers and local coordination environments. Among these catalysts, CoPc-based structures exhibit markedly enhanced water dissociation kinetics and elevated C–C coupling energy barriers compared to conventional CuPc-based catalysts, thereby effectively suppressing undesired C 4 by-products. Furthermore, molecular regulation of the Co center optimizes active hydrogen adsorption and utilization, mitigating both hydrogen evolution and over-hydrogenation. As a result, the optimized CoPc/NCNT catalyst delivers competitive performance under both high current densities and ethylene-rich conditions. At an industrially relevant −500 mA cm −2 under a pure ethylene feed, it achieves 86.7% Faradaic efficiency with a turnover frequency of 7019 min −1 . Under simulated industrial crude conditions, it maintains 99.7% conversion and 99.5% selectivity during 110-hour continuous operation. This work provides a well-defined molecular strategy for advancing selective electrocatalytic transformations.
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PubMed
高影响因子
JOURNAL OF MATERIALS RESEARCH
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2026
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IF 2.9
Li Xiaolan,Li Yang,Li Xuexin,Zhang Jihao,Wang Haozhang,Hu Siheng,Lei Ruixin,Liao Wenyong,Li Chunchun,Li Fei,Li Jinglei
High-power pulse systems demand dielectric ceramics with high recoverable energy storage density ( W rec ), efficiency, and stability. Relaxor ferroelectrics are promising due to high polarization and low loss. In this work, a binary solid solution of 0.7Na 0.5 Bi 0.5 TiO 3 -0.3Sr 0.7 Bi 0.2 TiO 3 was used as the base composition. A series of high-entropy relaxor ferroelectric ceramics, (1- x )(0.7NBT-0.3SBT)- x (Ca 0.5 Ba 0.5 )(In 0.5 Ta 0.5 )O 3 ( x = 0.05 ~ 0.30), featuring highly disordered crystal structures, were synthesized via a solid-state reaction method through simultaneous multi-cation doping at both the A- and B-sites. Characterization techniques including structural analysis, morphology observation, and basic electrical property measurements demonstrated that this A/B-site co-doping strategy effectively enhanced the relaxor characteristics. Systematic evaluation of energy storage performance identified the optimal composition ( x = 0.1), which achieves a W rec of 1.1 J·cm −3 at 110 kV·cm −1 , representing a relatively high value for bulk ceramics under moderate electric fields. These findings provide experimental support and a technical reference for developing high-performance energy storage ceramics. Graphical abstract The alternative text for this image may have been generated using AI.
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高影响因子
危险品化学品经营许可证（带存储）