Applied Nanoscience
·
2019
·Vol. 10
·期 4
·1131-1139
·
IF 3.198
Xie Liqiang,Li Hengfeng,Yang Zhengchun,Zhao Xinhao,Zhang Honghao,Zhang Ping,Cao Zongsheng,He Jie,Pan Peng,Liu Jun,Wei Jun,Song Dianyou,Qi Wen
In this work, we have developed a rapid and simple approach for fabrication of graphene-like materials. It consisted of shearing commercial graphite in aqueous solution with the assistance of ultrasonication. The results showed that the graphene-like materials were successfully fabricated with not only similar flake structure of graphene, but also improved conductivity. For the applications of flexible supercapacitors, the as-prepared graphene-like materials showed better specific capacitance than commercial graphite as the working electrode. In addition, the rate capability of the flexible supercapacitor device is 80% and the capacitance retention reaches 90% after 10,000 cycles. The high flexibility of the as-fabricated graphene-like materials gives rise to high flexibility of all-solid-state supercapacitors, and the specific capacitance was not affected by bending state. The as-fabricated supercapacitor further demonstrated that it can drive the resistive pressure sensor and the voltage was stable at a fixed value under different values of pressure.
✓ 已验证
产品关联
DOI
高影响因子
ARCHIVES OF MICROBIOLOGY
·
2019
·Vol. 202
·期 1
·181-189
·
IF 1.642
Zhang Guo-fang,Huang Qiu-liang,Bi Xue-qin,Liu You-lin,Yuan Zong-sheng
The structure and diversity of microbial communities in the leaves of Cinnamomum camphora at different growth stages were studied by high-throughput sequencing. Moreover, the relationships between microbial communities and borneol content were analyzed in this paper. The results indicated that the community structure of endophytic bacteria in C. camphora exhibited temporal variations, with the microbial diversity presented as follows: T1 (low content period) > T3 (peak period) > T2 (small peak period). The population of endophytic bacteria and the ratio of primary metabolism in the leaves of C. camphora were T2 > T1 > T3, while the metabolic intensity of endophytic bacterial terpenoids and polyketides was T3 > T2 > T1, which had the same trend as borneol content in C. camphora . The metabolic ratio of terpenoids and polyketides in T3 was 7.44% higher than that in T1, while that in T2 was 4.10% higher than that in T1. The abundance and diversity of Clostridium_sensu_stricto_1 , Ochrobactrum, Escherichia-Shigella, Pseudomonas , and Massilia significantly promoted the content of terpenoids in C. camphora . Together, those results provide the first evidence that borneol content and potential metabolic intensity in leaves of C. camphora greatly depend on microbial communities composition and diversity.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-16
·
IF 17.694
Li Fangyuan,Sun Heng,Ren Jiafeng,Zhang Bo,Hu Xi,Fang Chunyan,Lee Jiyoung,Gu Hongzhou,Ling Daishun
Platinum (Pt) resistance in cancer almost inevitably occurs during clinical Pt-based chemotherapy. The spontaneous nucleotide-excision repair of cancer cells is a representative process that leads to Pt resistance, which involves the local DNA bending to facilitate the recruitment of nucleotide-excision repair proteins and subsequent elimination of Pt-DNA adducts. By exploiting the structural vulnerability of this process, we herein report a nuclease-mimetic Pt nanozyme that can target cancer cell nuclei and induce concurrent DNA platination and oxidative cleavage to overcome Pt drug resistance. We show that the Pt nanozyme, unlike cisplatin and conventional Pt nanoparticles, specifically induces the nanozyme-catalyzed cleavage of the formed Pt-DNA adducts by generating in situ reactive oxygen species, which impairs the damage recognition factors-induced DNA bending prerequisite for nucleotide-excision repair. The recruitment of downstream effectors of nucleotide-excision repair to DNA lesion sites, including xeroderma pigmentosum groups A and F, is disrupted by the Pt nanozyme in cisplatin-resistant cancer cells, allowing excessive accumulation of the Pt-DNA adducts for highly efficient cancer therapy. Our study highlights the potential benefits of applying enzymatic activities to the use of the Pt nanomedicines, providing a paradigm shift in DNA damaging chemotherapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 30
·期 10
·28247-28258
·
IF 5.19
Shi Guangyu,Hu Jiayuan,Cheng Yuanyuan,Shi Weilin,Chen Yan
The effect of Pseudomonas aeruginosa ( P. aeruginosa ) on the phytoremediation efficiency of ryegrass on soil contaminated with nonylphenol (NP) and cadmium (Cd) was investigated by pot experiments. Pseudomonas aeruginosa application stimulated the adsorption of Cd by ryegrass and facilitated the biodegradation of NP in the soil. Exogenous P. aeruginosa inoculation increased the activities of urease, dehydrogenase, and polyphenol oxidase in the soil of the T4 treatment by 38.5%, 50.0%, and 56.5% compared to that of the T2 treatment, respectively. There was a significant positive correlation between the activities of dehydrogenase and polyphenol oxidase and the NP removal rate ( P < 0.001). The relative abundances of beneficial microorganisms (such as Sphingomonas , Lysobacter , Streptomyces , Chloroflexia, Deltaproteobacteria, and Alphaproteobacteria) were increased as a result of P. aeruginosa inoculation. These microorganisms play important roles in nutrient cycling, Cd adsorption, and NP degradation. Additionally, P. aeruginosa was not the dominate bacterial species at the end of the experiment. According to this study, P. aeruginosa application improved the phytoremediation efficiency of ryegrass on soil contaminated with NP and Cd, with a minimal risk of alien microbial invasion.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CELLULOSE
·
2022
·Vol. 30
·期 2
·1245-1264
·
IF 6.123
Ren Jinyong,Piao Junxiu,Wang Yaofei,Wang Yaxuan,Feng Tingting,Liu Lei,Jiao Chuanmei,Chen Xilei
The high flammability of cotton fabric limits its wide application in interior decoration and clothing. In this work, a phosphorus/nitrogen compound named chitosan modified ammonium polyphosphate (CS@APP) was facilely prepared by mechanochemical strategy and used for flame retardant finishing of cotton fabric (CF). The characterization results showed that CS@APP was successfully synthesized through the –NH 3 + –O − P– bond. The CF with CS@APP showed remarkable reductions of 88.7% and 61.3% in peak heat release rate (pHRR) and total heat release rate than CF. Also, the limiting oxygen index of flame retardant CF reached 53.5%, and the damaged length during the vertical flammability test was 84 mm. The flame-retardant mechanism was speculated on char residues and pyrolysis gas. The work provides new sights on the facile synthesis of phosphorylated chitosan and explores a new way to the utilization of biological resources. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
Scientific Reports
·
2022
·Vol. 12
·期 1
·1-23
·
IF 4.996
Saleh Ahmed K.,El-Gendi Hamada,El-Fakharany Esmail M.,Owda Medhat E.,Awad Mohamed A.,Kamoun Elbadawy A.
The promising features of most bacterial celluloses (BC) promote the continuous mining for a cost-effective production approach toward wide and sustainable applications. Herein, cantaloupe peels (CP) were successfully implemented for sustainable BC production. Results indicated that the enzymatically hydrolyzed CP supported the maximum BC production of approximately 3.49 g/L when used as a sole fermentation media. The produced BC was fabricated with polyvinyl alcohol (PVA) and chitosan (Ch), and loaded with green synthesized copper oxide nanoparticles (CuO-NPs) to improve its biological activity. The novel composite showed an antimicrobial activity against several human pathogens such as Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, and Pseudomonas fluorescens . Furthermore, the new composite revealed a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells, with low IC 50 of 0.48, 0.27, and 0.33 mg/mL for the three cell lines, respectively. On the other hand, the new composite was remarkably safe for human skin fibroblast (HSF) with IC 50 of 1.08 mg/mL. Interestingly, the composite membranes exhibited lethal effects against all stages of larval instar and pupal stage compared with the control. In this study, we first report the diverse potential applications of BC/PVA/Ch/CuO-NPs composites based on green synthesized CuO-NPs and sustainably produced BC membrane.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2022
·Vol. 189
·期 11
·1-10
·
IF 6.408
Bu Yiming,Yin Ranhao,Yu Long,Su Pengchen,Li Zibiao,Ye Enyi,Loh Xian Jun,Zhu Houjuan,Wang Suhua
An enhanced ratiometric fluorescence sensor was built for on-site visual detection of doxycycline (DOX) through the interaction with bovine serum albumin on the surface of red emissive copper nanoclusters. Upon the addition of weakly fluorescent DOX, the red fluorescence from copper nanoclusters gradually decreased through the inner-filter effect (IFE), while a green fluorescence appears and significantly increases, forming an interesting fluorescent isosbestic point, which was assigned to DOX due to sensitization effect of bovine serum albumin. On the basis of this ratiometric fluorescence, the system possessed good limit of detection (LOD) of 45 nM and excellent selectivity for DOX over other tetracyclines. Based on these findings, a paper-based sensor has been fabricated for distinct visual detection of trace DOX and combined with smartphone color recognizer for quantitative detection of DOX (LOD = 83 nM). This method shows broad application prospects in environmental monitoring and food safety. Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano-Micro Letters
·
2022
·Vol. 14
·期 1
·1-15
·
IF 23.655
Guo Cong,He Lu,Yao Yihang,Lin Weizhi,Zhang Yongzheng,Zhang Qin,Wu Kai,Fu Qiang
The phase change materials possess conformable configuration to the structure of Li-ion batteries in macro-scale and multidirectional thermal pathways for rapid and uniform heat transfer in micro-scale.
Hierarchically structured phase change materials achieve dual-mode thermal management ability for heating and cooling Li-ion batteries.
Excellent practical battery thermal management performance was verified by 18,650 Li-ion batteries in both cold and hot environments.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Microbial Cell Factories
·
2022
·Vol. 21
·期 1
·1-14
·
IF 6.352
Guo Fei,Zhang Xingwang,You Cai,Zhang Chengjie,Li Fengwei,Li Nan,Xia Yuwei,Liu Mingyu,Qiu Zetian,Zheng Xianliang,Ma Li,Zhang Gang,Luo Lianzhong,Cao Fei,Feng Yingang,Zhao Guang-Rong,Zhang Wei,Li Shengying,Du Lei
Background Glucoside natural products have been showing great medicinal values and potentials. However, the production of glucosides by plant extraction, chemical synthesis, and traditional biotransformation is insufficient to meet the fast-growing pharmaceutical demands. Microbial synthetic biology offers promising strategies for synthesis and diversification of plant glycosides.Results In this study, the two efficient UDP-glucosyltransferases (UGTs) (UGT85A1 and RrUGT3) of plant origin, that are capable of recognizing phenolic aglycons, are characterized in vitro. The two UGTs show complementary regioselectivity towards the alcoholic and phenolic hydroxyl groups on phenolic substrates. By combining a developed alkylphenol bio-oxidation system and these UGTs, twenty-four phenolic glucosides are enzymatically synthesized from readily accessible alkylphenol substrates. Based on the bio-oxidation and glycosylation systems, a number of microbial cell factories are constructed and applied to biotransformation, giving rise to a variety of plant and plant-like O-glucosides. Remarkably, several unnatural O-glucosides prepared by the two UGTs demonstrate better prolyl endopeptidase inhibitory and/or anti-inflammatory activities than those of the clinically used glucosidic drugs including gastrodin, salidroside and helicid. Furthermore, the two UGTs are also able to catalyze the formation of N- and S-glucosidic bonds to produce N- and S-glucosides.Conclusion sTwo highly efficient UGTs, UGT85A1 and RrUGT3, with distinct regioselectivity were characterized in this study. A group of plant and plant-like glucosides were efficiently synthesized by cell-based biotransformation using a developed alkylphenol bio-oxidation system and these two UGTs. Many of the O-glucosides exhibited better PEP inhibitory or anti-inflammatory activities than plant-origin glucoside drugs, showing significant potentials for new glucosidic drug development.
✓ 已验证
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2022
·Vol. 415
·期 5
·887-897
·
IF 4.478
Ren Rongfan,Li Hongli,Jiang Qing,Wang Xing,Chen David Da Yong
Characterization of structural isomers of bioactive molecules is important for recognizing their functions, but it has been challenging due to their highly similar structures. As the main bioactive constituents of Panax ginseng , ginsenosides have different structural isomers attributed to the aglycone structure and glycosylation sites as well as stereochemistry of sugar groups attached. This work demonstrated a simple and robust in situ methylation reaction with tetramethylammonium hydroxide (TMAH) using ambient ionization source of direct analysis in real time (DART) to characterize saponin structural isomers. The DART ion source provides favorable conditions to methylate hydroxyl groups of ginsenoside instantaneously with TMAH, and it can ionize the methylated products at the same time. Methylated ginsenoside stereoisomers even with subtle structure differences generated very different mass signals from full-scan MS and tandem MS. High-resolution mass spectrometry aided the assignment of molecular structures of the various precursor and fragment ions from different ginsenosides, which provided structural information for both the aglycone skeleton and the sugar moieties in ginsenosides. The presented method was successfully used for the identification of ginsenosides in Panax ginseng , and saponin isomers were characterized without the need for chromatographic separation and/or tedious offline sample pretreatment. Graphical Abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Analysis and Testing
·
2022
·Vol. 7
·期 2
·147-156
·
IF 0
Yang Xiaohua,Zhang Peigang,Tan Jie,Li Xuebing,Zhang Weidong,Bian Wei,Choi Martin M. F.
Owing to the excellent stability, biocompatibility and photoluminescence property, graphene quantum dots (GQDs) are emerging as a kind of potential materials to be applied in a series of fields ranging from sensor to drug delivery. As the growing concern for human and environmental safety, selective detection of metal ions has been paid more and more attention. GQDs, as nanoparticles with superior optical properties, have been attracting growing attention in the field of metal ions detection. In this work, glutathione(GSH) functionalized boron doped graphene quantum dots (B-GQDs@GSH) were successfully synthesized with stable bright blue fluorescence and has been used for the detection of Fe 3+ . A good linear relationship between 1/( F 0 ‒ F ) and 1/ c with the concentration ranging from 0.70 to 53 μmol/L was obtained with a detection limit of 5.5 nmol/L. The application of B-GQDs@GSH for Fe 3+ detection in water samples was demonstrated and the quenching mechanism was further explored. Due to low cytotoxicity and favorable biocompatibility, B-GQDs@GSH were successfully applied for cell fluorescence imaging and intracellular determination of Fe 3+ .
✓ 已验证
产品关联
DOI
JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 41
·19381-19395
·
IF 4.682
Tian Zhongqing,Wang Dandan,Zhang Chunyan,Meng Fancheng,Cao Liangliang,Lin Huixing
Fabricating flexible, solid, miniature and low-cost energy storage units has received growing attention as the rapid development of flexible electronic devices. Herein, we demonstrate the easy manufacturing of all-solid-state flexible supercapacitor with in-plane interdigital electrode architecture based on nickel–cobalt bimetallic sulfide NiCo 2 S 4 . With the help of a shadow mask printing technique, the NiCo 2 S 4 -based electrodes were printed on a flexible PET substrate using the home-made ink comprised of NiCo 2 S 4 , carbon nanotubes, PTFE and terpineol. Then a PVA-KOH gel electrolyte was coated and cured to complete the assembly of interdigital supercapacitor. The NiCo 2 S 4 electrode exhibits a high specific capacitance of 1401 F/g. After 3000 cycles, the capacitance retention maintains 90%, showing a remarkable cycle stability. The assembled interdigital device delivers a high specific areal capacitance of 13.6 mF/cm 2 at a current density of 0.35 mA/cm 2 and an excellent energy density of 2.1 μWh/cm 2 at a power density of 0.189 mW/cm 2 , with both long-term cycling and high rate stability. The electrochemical performance remained consistent at different bending angles (0°, 90° and 180°). This work demonstrates a simple and low-cost preparation of printable supercapacitor based on NiCo 2 S 4 interdigital electrodes, which has a great potential to be used for flexibility, wearable and portable devices. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）