Nature Communications
·
2026
·
IF 18.1
Li Pingping,Zhang Ming,Hu Yubin,Dai Xiangcheng,Asif Muhammad Mohtashim,Zhao Junjie,Kim Donghun,Celebi Kemal
Zeolite nanosheets offer promising opportunities to fabricate ultrathin molecular sieving platforms for energy-efficient and cost-effective gas separation. However, activating these nanosheets requires a high-temperature calcination process that opens the pores, causing drying and subsequent irreversible aggregation. Once aggregated, most nanosheets cannot be well-aligned to form a continuous thin membrane, which is a persistent bottleneck for mixed matrix membrane fabrication. In this study, we present a facile ultraviolet (UV)-ozone treatment that activates zeolite nanosheets (MFI and SAPO-34) in aqueous solution. This treatment prevents the drying and aggregation of the nanosheets, thereby ensuring high yields of solvent dispersion for open-pore nanosheets. Furthermore, the UV-ozone treatment also introduces hydroxyl groups on the nanosheet surface that enhance both CO 2 adsorption and interfacial compatibility with the polymer matrix. The activated nanosheets are then used to fabricate micrometer-thick, highly b -oriented MFI mixed matrix membranes on polymer substrates via solution casting. These membranes demonstrate high CO 2 /N 2 selectivity of 40 ± 6, with permeance of 194 ± 50 GPU (at 25 °C, ambient pressure). This method is thus substantiated as an effective and scalable approach for activating zeolite nanosheets and can be a cost-efficient approach for the fabrication of thin, flexible zeolite-nanosheet-based gas separation membranes.
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高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 5
·302
·
IF 5.4
Song Jinrong,Chen Junyu,Tian Rui,Li Haoyu,Bai Wanqiao,Yang Hua,Sun Xuehua
Metal nanoclusters have emerged as promising fluorescence nanomaterials, yet their practical sensing applications remain constrained by limited stability and suboptimal luminescence efficiency. We report a strategically designed nanocomposite, chitosan/silica-encapsulated gold nanoclusters (Au NCs/CSNPs), which integrates three functional components into the fluorescence sensing platform. Unlike conventional encapsulation strategies that merely serve as protective shells, our chitosan-functionalized silica matrix achieves multiple synergistic functions, where rigid confinement enhances quantum yield and photostability, chitosan-induced improvement analyte accessibility, and the tailored composite microenvironment enables analyte-specific response modulation. Remarkably, Au NCs/CSNPs exhibit opposite fluorescence responses toward two distinct contaminants, with enhancement for 2-nitroaniline (2-NA) and quenching for fluazinam (Flu), enabling selective detection with low limits of detection of 52.2 nM for 2-NA and 45.7 nM for Flu. Mechanistic studies reveal that this dual-response behavior originates from distinct pathways including excited-state rigidification for 2-NA versus static quenching coupled with the inner filter effect for Flu. The sensor demonstrates excellent selectivity and practical applicability in environmental and food matrices. This work establishes a new paradigm for nanocluster-based sensors where the encapsulating matrix is not merely protective but functionally integrated to achieve tunable multi-analyte sensing capabilities. Graphical abstract
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Science China-Technological Sciences
·
2026
·Vol. 69
·期 4
·1420501
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IF 5.1
Zhang Mingdong,Zhang Yan,Yuan Aocheng,Feng Meiling,Mu Jingli
Metal sulfide ion exchangers (MSIEs) are promising for radioactive wastewater treatment due to their soft S 2− -containing frameworks and ion-exchange capabilities. However, their fine powder form and susceptibility to competing ions limit practical application in complex water matrices. Herein, we developed a novel MSIE-based composite, K 2 ZnSn 2 S 6 nanosheets/cationic polyacrylamide (KZTS-NS/CPAM) flocs, integrated with an improved accumulative countercurrent adsorption (iACA) process for effective Cs + , Sr 2+ , and Co 2+ removal. The composite flocs exhibited good settling performance, achieving complete sedimentation within 40 s. Their maximum adsorption capacities ( q m ) reached 106.7, 43.54, and 40.54 mg/g for Cs + , Sr 2+ , and Co 2+ , respectively, close to or even higher than those of KZTS-NS. The adsorption kinetics were rapid, reaching equilibrium within 40 min. Furthermore, the flocs showed broad pH tolerance (removal efficiencies ⩾86.93% for Cs + at pH 4–11, ⩾95.10% for Sr 2+ at pH 3–12, and ⩾96.17% for Co 2+ at pH 1–8) and ultrahigh selectivity for Co 2+ (distribution coefficients up to 6.63×10 6 mL/g under competitive conditions). When integrated with the iACA process, >93% of Cs + and >99% of Sr 2+ and Co 2+ were removed from tap water. Notably, 93.76% of Co 2+ was removed from seawater without microfiltration, benefiting from both the composite’s strong selectivity and excellent settling behavior. The average turbidity of the effluents was as low as 28.6 NTU. Thus, no additional solid-liquid separation step was needed. Mechanistic studies confirmed three key pathways: (1) ion exchange between Cs + /Sr 2+ /Co 2+ and interlayer K + in KZTS-NS; (2) amide complexation by CPAM for Sr 2+ and Co 2+ ; and (3) surface precipitation for Co 2+ forming Co 1.2 Zn 2.8 S 4 . Overall, this material-process integration provides an innovative strategy for radionuclide remediation in actual and high-salinity water environments, offering new insights into the design of processable composite adsorbents and advanced treatment processes.
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npj Science of Food
·
2026
·
IF 9.7
Wang Xiaoran,Song Yagang,Zhao Wenyu,Liu Yuting,Fu Yiping,Zhang Yu,Zhao Quanyou,Miao Mingsan,Zhao Wenxia,Wang Xianbo,Li Zhanzhan
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health burden with limited therapeutic options. Cinnamomum cassia , a medicinal-food homologous plant, contains principal bioactive cinnamaldehyde (CA), whose anti-MASLD mechanisms require clarification. This study employed both a high-fat diet (HFD)-induced MASLD model and a free fatty acid (FFA)-stimulated cell model. CA administration attenuated intracellular lipid accumulation in vitro and ameliorated both hepatic steatosis and systemic hyperlipidemia in vivo, while inhibiting hepatic lipid peroxidation. Mechanistically, integrated RNA-seq, network pharmacology, siRNA, immunofluorescence, and transmission electron microscopy analyses identified the SIRT1/FOXO1–autophagy axis as CA’s key regulatory pathway. Gut microbiome profiling revealed CA’s capacity to ameliorate HFD-induced dysbiosis, particularly enriching Lachnospiraceae_NK4A136 . Fecal microbiota transplantation (FMT) and Spearman correlations link serum lipids and hepatic injury factors to gut microbiota, indicating partially microbiota-mediated metabolic modulation by CA. Collectively, CA ameliorates MASLD through coordinated autophagy enhancement and microbial homeostasis restoration, holding promise as a functional food ingredient for metabolic liver disease prevention.
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PHARMACEUTICAL RESEARCH
·
2026
·
IF 4.1
Mo Jiajia,He Emily M.,Zhao Yan,Shao Li,Yue Shaoyun,Xie Yanmei,Wu Shiqi,He Jianxun,Zou Yi,Chu Zhaoxing,He Guangwei,Xu Yungen
Purpose Patients with acute coronary syndrome (ACS) require rapid and potent antiplatelet therapy during percutaneous coronary intervention (PCI). Current first-line P2Y₁₂ inhibitors are limited by delayed efficacy or an ultrashort half-life. This study aims to characterize the metabolism and pharmacodynamics of HY-022619, a disodium phosphate ester salt of ticagrelor, to provide a theoretical basis for its clinical use in peri-PCI antithrombotic therapy. Methods The inhibitory activity of HY-022619 against the P2Y₁₂ receptor and ADP-induced platelet aggregation was evaluated in vitro . Molecular docking was performed to compare its receptor-binding mode with ticagrelor. Metabolic stability was assessed in whole blood, liver microsomes, and using recombinant enzymes. Pharmacodynamic profiles were investigated in rats and beagle dogs, with additional assessments of metabolic conversion and bleeding time in dogs. Results HY-022619 showed 22-fold greater P2Y₁₂ receptor inhibition and 15-fold stronger suppression of platelet aggregation than ticagrelor. Molecular docking revealed that enhanced activity was due to an additional salt bridge. HY-022619 remained stable in human and non-rodent whole blood (half-life > 60 min) and was primarily hydrolysed to ticagrelor in the liver by CES1 and CES2. In rats, intravenous administration produced rapid, dose-dependent platelet inhibition within 5 min. In dogs, HY-022619 acted rapidly with efficacy peaking at the end of infusion. It converted completely to ticagrelor within 5 min post-infusion, maintaining antiplatelet effects for 6 h, without significantly prolonging bleeding time compared to ticagrelor. Conclusion HY-022619 demonstrates rapid, potent, and sustained antiplatelet effects, supporting its potential clinical application. Graphical
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Liang Jing,Liang Zhongdan,Tang Li,Qin Guoxin,Jiang Cuiwen,Wang Yanli,Luo Lihong,Xie Liping,Li Tao,Huang Xiaochuan,Yan Feiyan,Huang Ke-Jing,Ya Yu
Current methods for detecting biotoxins are hindered by complex sample preparation and dependence on sophisticated instrumentation. Consequently, there is an urgent need for innovative solutions that facilitate efficient and portable detection capabilities. Herein, a self-powered biosensing platform based on enzyme-based biofuel cells (EBFCs) is reported for the first time for ultrasensitive detection of aflatoxin B1 (AFB1), utilizing gold-embedded hierarchical porous carbon (Au@HPC) and enzymatic signal amplification. Au@HPC was prepared to function as an electrode material of EBFCs for constructing superior EBFCs, representing a novel application of this composite in a self-powered sensing platform. An aptamer-based selective recognition strategy coupled with enzymatic signal amplification was further implemented to monitor the bioelectrocatalytic response toward AFB1. Synergy of enzymatic signal amplification and high-performance carrier material (Au@HPC) amplified electrical signals, markedly improving the sensitivity of the detection platform. As a result, AFB1 could be reliably identified over a wide concentration range of 0.01–10 4 pg/mL, with a detection limit reaching the femtogram level (1.52 fg/mL, S/N = 3). This study presents a highly accurate, sensitive, and portable detection method suitable for rapid analysis in real food samples. Graphical abstract
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Nature Communications
·
2026
·
IF 18.1
Ma Huijing,Wang Haifei,Cai Chengcheng,Song Hongyu,Guo Qianqing,Long Xia,Qian Xufang,Zhao Yixin
Low-platinum-loading electrocatalysts, offering both high activity and durability under practical conditions, are essential for sustainable hydrogen production. Here we report a scalable synthesis of a platinum single-site catalyst supported on Ni-N-doped carbon nanotubes, achieved via a facile Ni-driven one-step reduction-displacement of Pt 4+ . The catalyst NCNT-Ni/Pt features a N 2 -Pt-Cl 2 initial coordination, where the dynamic evolution of Pt-Cl bonds regulates the hydrogen evolution reaction performance. Excitingly, the catalyst demonstrates an overpotential of 7.78 ± 0.86 mV at 10 mA cm –2 . With a Pt loading of 6 μg cm –2 , it enables industrially relevant proton exchange membrane water electrolysis at 1.63 V@1 A cm –2 , with a degradation rate of 3.3 μV h –1 , sustained over 4500 h. Coupled with a 21%-efficient photovoltaic module, it delivers a 16.06% solar-to-hydrogen efficiency at industrial-level current density. This study presents a practical strategy for minimizing precious-metal use in the synthesis of industrial-grade hydrogen evolution electrocatalysts.
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JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
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2026
·
IF 3.4
Wu Wei-tong,Huang Jia-yi,Lai Yi-shan,Tan Hui-lan,Wang Lang-hong,Zeng Xin-An,Huang Yan-yan
Colitis is an intestinal disorder characterized by colonic mucosal or submucosal inflammation. Probiotic intervention is a potential biotherapeutic strategy for adjuvant colitis management. This study evaluated the effects of Lactiplantibacillus plantarum HYY-DB36 ( L. plantarum DB36) using a dextran sulfate sodium (DSS)-induced murine colitis model. Key findings: compared with the DSS model group, L. plantarum DB36 significantly ameliorated colonic histopathological damage and inflammation, elevated intestinal short-chain fatty acid levels, suppressed harmful bacteria proliferation, and promoted beneficial bacteria enrichment. In conclusion, L. plantarum DB36 has great potential for adjuvant colitis therapy, with its role in modulating intestinal microbial homeostasis supporting its promise as a probiotic resource for alleviating colitis symptoms. Graphical abstract The Potential Specific Mechanism by Which L.plantarum DB36 Alleviates DSS-Induced Colitis Through Modulation of the Gut Microbiota.
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JOURNAL OF MATERIALS SCIENCE
·
2026
·Vol. 61
·期 44
·34915-34934
·
IF 4.4
Hu Yiting,Liu Zhixiong,Liu Bei,Zou Qiuling,Li Fei,Xiang Yanhong,Liu YanHong
This study aimed to develop a dual-functional one-pot strategy for spent LiNi 0.5 Co 0.2 Mn 0.3 O 2 (NCM523) cathode scraps by integrating selective lithium recovery with the in-situ conversion of residual transition metals into value-added functional materials. A sodium persulfate (SPS)-assisted reaction system was constructed, and methylene blue (MB) was selected as a model organic pollutant to evaluate the photocatalytic performance of the converted products. The effects of calcination pretreatment, SPS dosage and initial pH were optimized, while reactive species and degradation pathways were investigated through mechanistic analysis and LC-MS/MS. Under the optimized conditions of calcination at 420 °C, SPS dosage of 1.0 g/L and initial pH 7.0, the lithium leaching efficiency reached 97.38%, lithium selectivity over co-leached Ni, Co and Mn reached 79.90%, and MB degradation efficiency in the one-pot system reached 91.50%. The delithiated residue was directly transformed into a ternary mixed-phase catalyst containing NiO, CoO and MnO 2 /MnO x , which achieved 98.29% MB degradation in an independent SPS-activation photocatalytic system. Mechanistic results indicated that photogenerated holes and multivalent Ni/Co/Mn redox cycles promoted the formation of singlet oxygen and superoxide radicals. Overall, this integrated route enables efficient lithium recovery, high-value utilization of residual metals and pollutant degradation, providing a promising waste-to-resource strategy for spent LIB cathode recycling and environmental remediation. Graphical abstract
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FIBERS AND POLYMERS
·
2026
·
IF 3.1
Hu Shen,Xie Jinlin,Zhang Boxuan,Wang Weiye,Ran Xuqin,Yang Ming,Li Xinyu,Kobesy Osama,Wei Guoke,Qiu Hua,Gu Peng
The rapid development of smart wearable technology has driven innovation in the field of flexible strain sensors. Carbon nanotube (CNT) fibers have emerged as promising candidates for the fabrication of flexible strain sensors due to their exceptional flexibility, remarkably high specific surface area, outstanding mechanical properties, and excellent electrical conductivity. However, interstitial voids between CNT bundles constitute structural defects that impair both load-bearing capacity and electron transport efficiency. This limitation can be effectively mitigated by incorporating metal nanoparticles, which not only fill these voids but also enhance composite performance through their intrinsic low electrical resistance and exceptional chemical inertness. In this study, MXene was utilized as a reducing agent to directly reduce platinum particles from chloroplatinic acid and autonomously grow into the voids of carbon nanotube yarns without the need for additional reducing agents. This modification strategy resulted in substantial enhancements in both mechanical and electrical properties: The tensile strength of platinum-modified CNT yarns increased from 121.2 to 137.27 MPa (13.3% increase), while electrical conductivity demonstrated an 85.3% improvement from 6.18×10 4 S/m to 11.45×10 4 S/m. The prepared flexible and stretchable strain sensors exhibit a resistive change of 380%, a tensile strain range of 0–30%, a GF sensitivity of 23.8, a fast response time of 0.6 s, a recovery time of 0.8 s, and dynamic sensing stability under varying conditions. Significantly, the sensor enables multi-channel synchronous monitoring of biomechanical signals at major human joints, establishing a new design framework for CNT yarn-based elastic strain sensors.
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WATER AIR AND SOIL POLLUTION
·
2026
·Vol. 237
·期 21
·1249
·
IF 3.5
Liu Guowei,Liu Baolong,Peng Xiaoqian,Gao Ning,Wang Sheng,Yuan Zhongshan,Chen Yingwen,Fan Mengjie
High-concentration N,N-dimethylformamide (DMF) wastewater presents a major challenge in hazardous chemical waste treatment due to its chemical stability, poor biodegradability, and significant biotoxicity. To address the insufficient thermal stability of conventional catalyst supports, limited activity of single metals, and the lack of synergistic catalyst–reactor process studies in thermocatalytic oxidation, this thesis focuses on multiphase fluidized-bed catalytic cracking and establishes an integrated “catalyst–reactor–process” technical system. Transition metal-doped alumina aerogel catalysts were prepared via a sol–gel method, with Ni and Cu identified as the optimal active components. The optimized Ni 3 Cu 2 O x –Al 2 O 3 catalyst (Ni/Cu oxide mass ratio of 3:2, calcined at 550 °C for 5 h) achieved 99.96% DMF cracking and 98.66% chemical oxygen demand (COD) removal for 8000 mg/L DMF at 380 °C. Characterization revealed a three-dimensional mesoporous structure with a specific surface area of 236.44 m 2 /g. The fluidized-bed operating parameters were systematically optimized, and good catalytic performance was obtained over a DMF concentration range of 8000–32000 mg/L. No apparent competitive inhibition was observed in DMF–phenol mixed wastewater, demonstrating the general applicability of the catalytic process. The constructed fluidized-bed/fixed-bed two-stage series process achieved deep purification, with DMF cracking approaching 100% and a maximum COD removal of 99.33%. This study provides an efficient catalytic process scheme for the harmless treatment of high-concentration DMF wastewater. Graphical
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WATER AIR AND SOIL POLLUTION
·
2026
·Vol. 237
·期 22
·1284
·
IF 3.5
Feng Xiaojian,Wang Haoxin,Xu Yanjun,Wu Chi,Pang Sen,Chen Yajie
Pyrethroids (PYRs) frequently occur in aquatic environments, but their distribution and accumulation in multi-compartment systems remain poorly understood. Permethrin (Per), fenpropathrin (Fen), and bifenthrin (Bif) were investigated in a 21-day water–sediment-zebrafish ( Danio rerio )- Myriophyllum spicatum microcosm. Per was added to water, whereas Per, Fen, and Bif were separately added to sediment. Concentrations in oleic acid-embedded cellulose acetate membranes (OECAMs) were converted to equivalent aqueous exposure concentrations using compound-specific OECAM-water partition coefficients. These values were used to derive apparent bioconcentration factors (BCFs) for zebrafish and accumulation factors for M. spicatum during the late exposure phase. At 504 h, sediment accounted for 58.46% of recovered Per in the water-spiked treatment, while zebrafish and M. spicatum accounted for 18.46% and 17.16%, respectively. In the sediment-spiked treatments, 99.43%-99.87% of recovered PYRs remained in sediment. After correction for pesticide removed by repeated sampling, recoverable parent mass decreased by 67.90% in the water-spiked treatment and by 27.64%-39.27% in the sediment-spiked treatments. OECAM-normalized apparent BCFs ranged from 389.31 to 970.11 L kg −1 wet weight in zebrafish, while accumulation factors ranged from 262.94 to 769.58 L kg −1 wet weight in M. spicatum . The OECAM-derived metric provided an exposure-related basis for interpreting organism accumulation under dynamic aqueous conditions, particularly when conventional water measurements became limited by low concentrations.
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危险品化学品经营许可证（带存储）