JOURNAL OF POLYMER SCIENCE
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2026
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IF 3.9
Chenghua Yu,Xueyi Huang,Junjiang Teng,Hao Ma,Yanhui Qiao,Chaochao Yue,Yating Wang
In this work, superhydrophobic chitosan microspheres were fabricated via spray drying of chitosan aqueous solution followed by surface silanization modification. Characterization methods, namely laser particle size analysis, SEM, and FTIR, were adopted to systematically investigate the particle size distribution, micromorphology, and chemical composition of chitosan microspheres. Experimental results revealed the dissolution medium exerted a remarkable effect on the microscopic morphology of as-prepared microspheres. Hydrophobicity characterization verified the silanized chitosan microspheres possessed excellent hydrophobic performance with a water contact angle of 153.3°. Antibacterial assays confirmed that the modified chitosan microspheres exhibited an antibacterial efficiency of 95.42% against Escherichia coli . Furthermore, functional composite coatings were constructed by uniformly spraying the modified chitosan microspheres onto filter paper substrates. The coated filter paper presented a water contact angle of 152.1°, which enabled it to achieve efficient separation of oil–water mixtures. Notably, the modified filter paper retained a water contact angle over 150.0° after immersion in acidic, neutral, and weakly alkaline solutions and maintained stable superhydrophobicity even after 90 cycles of weighted friction tests. This study proposes feasible technical strategies for the functional modification of chitosan microspheres and offers valuable references for their practical deployment as coating materials in functional filter paper fabrication. Graphical Chitosan microparticles are prepared by spray drying and subsequent silane grafting. Silane modification provides superhydrophobicity, while the inherent amino groups of chitosan deliver favorable antibacterial properties, resulting in constructing multifunctional biomass materials.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Yanhui Li,Wenhu Zhou
A green fluorescent cholesterol biosensor (ChOx-MNH) was developed by immobilizing cholesterol oxidase (ChOx) within a nanomagnetic chitosan–polyacrylamide (CS–PAAm) hydrogel matrix. The structural, morphological, and magnetic properties of the biosensor were examined using FT-IR, XRD, TGA, FE-SEM, TEM, BET, MTT, and VSM analyses. The resulting ChOx-MNH acts as a metal-oxide/enzyme composite catalyst, thereby establishing a cascade-based sensing approach for cholesterol determination. ChOx catalyzes the oxidation of cholesterol, followed by the catalytic decomposition of generated hydrogen peroxide (H 2 O 2 ) into highly reactive hydroxyl radicals ( • OH) by Fe 3 O 4 nanoparticles. These radicals subsequently react with coumarin to form fluorescent 7-hydroxycoumarin, whose emission intensity increases proportionally with cholesterol concentration. During method development, the effects of coumarin concentration, reaction medium pH, and nanozyme (Fe 3 O 4 ) content on the fluorescence response were systematically evaluated, and suitable operating conditions were selected to ensure efficient signal generation. Under these conditions, the biosensor enabled selective and quantitative cholesterol detection over a linear range of 0.0996–12.93 mM with a limit of detection of 0.4638 mM. In addition to its analytical performance, the proposed platform offers advantages such as low cost, environmental compatibility, and convenient magnetic separation. The practical applicability of the ChOx-MNH was further demonstrated by the analysis of human serum samples, which showed good agreement with a commercial diagnostic kit. Download: Download high-res image (210KB) Download: Download full-size image
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Pharmaceutics
·
2026
·Vol. 18
·期 6
·682
·
IF 6.9
Shiyuan Lin,Feixian Lu,Qiao Li,Kefeng Zhang,Wei Zhang,Hui Chen,Jianxin Wang
Background : Hepatic fibrosis is characterized by the abnormal activation of hepatic stellate cells (HSCs) and excessive deposition of the extracellular matrix. Currently, effective clinical therapeutic strategies remain limited. Modulating ferroptosis-related pathways in activated HSCs has emerged as a promising therapeutic target for hepatic fibrosis treatment. Methods : An amphiphilic copolymer was synthesized by conjugating COS with ART, which spontaneously self-assembled into micelles; subsequent modification with retinoic acid (RA) yielded RA-functionalized ART–COS copolymer micelles. Curcumin was selected as a model drug to evaluate the potential of the micelles in enhancing intestinal epithelial transport, oral absorption and bioavailability. Meanwhile, in vitro targeting ability, capacity to modulate ferroptosis in HSCs and in vivo therapeutic efficacy were systematically investigated. Results : The RA-functionalized ART–COS micelles significantly enhanced intestinal epithelial drug transport, oral absorption, and bioavailability. In vitro experiments demonstrated that the micelles preferentially accumulate in activated HSCs, inhibit GPX4 expression, and induce excessive ROS production and ferroptosis, thereby effectively attenuating hepatic fibrosis. In vivo studies confirmed that the micelles regulated extracellular matrix metabolism, reduced collagen deposition, suppressed the activation and proliferation of HSCs, and ultimately helped attenuate hepatic fibrosis progression. Conclusions : This study successfully developed RA-functionalized ART–COS copolymer micelles. The micelles improve the accumulation of artesunate in liver tissue and yield favorable anti-fibrotic effects, thereby providing a promising translational strategy for anti-fibrotic therapy.
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Polymers
·
2026
·Vol. 18
·期 10
·1237
·
IF 5.8
Danyun Lei,Weiyi She,Xiaoyu Chen,Lei You,Ying Zheng,Byoung-Suhk Kim
Chitosan (CS) was employed to modify coconut shell activated carbon (CAC) to fabricate a composite adsorbent for wastewater treatment. By integrating the functional groups of CS with the high specific surface area of CAC through chemical modification, the resulting CS-AC composite exhibited significantly enhanced adsorption performance toward hexavalent chromium (Cr(VI)) in aqueous solutions. The effects of key parameters, including adsorbent dosage, initial Cr(VI) concentration, contact time, temperature, and solution pH on the adsorption efficiency were systematically investigated. Under optimal conditions, the CS-AC composite achieved a Cr(VI) removal efficiency of up to 99.04%. Kinetic and isotherm modeling revealed that the adsorption process followed the pseudo-second-order kinetic model and was well described by the Langmuir isotherm. Regeneration studies conducted over five consecutive adsorption-desorption cycles demonstrated that the composite retained a high removal efficiency of 98.10%, indicating excellent reusability. These findings suggest that the CS-AC composite is a promising and effective adsorbent for the removal of Cr(VI) from contaminated water.
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JOURNAL OF BIOMATERIALS APPLICATIONS
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2026
·
IF 2.4
Jiajie Li,Huanyu Zhong,Danyang Li,Na Peng
Post-traumatic wound management is a critical issue that needs to be addressed. Chitosan (CS) with inherent biocompatibility and biodegradability is widely applied in wound healing, but the products of CS often suffer from poor water solubility and mechanical strength. Herein, we developed new double-crosslinked CS-based cryogels. Firstly, glycidyl methacrylate (GMA) was used to modify CS for the crosslinking of double bonds, followed by further crosslinking with 1,4-butanediol diglycidyl ether (BDDE). A series of CS-based cryogels were prepared by adjusting the concentration of CS from 2wt% to 4wt% and the content of BDDE from 0.1vol% to 0.4vol%. The CS-based cryogels demonstrated enhanced mechanical properties as the concentration of CS increased, higher swelling capacity as the content of BDDE increased and potent antioxidant activity around 80%. The CS-based cryogels exhibited broad-spectrum antibacterial performance, with antibacterial rates over 90% against both S. aureus and E. coli. Cytotoxicity and hemolysis assays confirmed the biocompatibility and hemocompatibility of the cryogels. The CS-based cryogels reduced blood loss in mice tail amputation models and accelerated tissue regeneration in full-thickness wound models demonstrating potential for clinical application. Among them, the CS3-GB3 cryogel demonstrated the most effective promotion of wound healing.
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Biomimetics
·
2026
·Vol. 11
·期 9
·639
·
IF 4.2
Lei Nie,Yingying Liang,Yiran Lin,Wei Guo
Rapid hemostasis, oxidative stress resistance, and minimally invasive administration are crucial performance requirements for high-performance wound covering. Inspired by the dynamic remodeling properties of the native extracellular matrix, we fabricated a multifunctional injectable hydrogel through dynamic Schiff-base crosslinking between oxidized hyaluronic acid (OHA) and carboxymethyl chitosan (CMCS), combined with magnesium ion (Mg2+) coordination. The effects of Mg2+content on hydrogel properties were systematically investigated. The hydrogels gelled rapidly under physiological conditions and showed good injectability, self-healing behavior, and favorable adhesion to moist tissues. Notably, Mg2+incorporation significantly enhanced hemostatic performance in a mouse tail amputation model, reducing blood loss from 391.7 mg to approximately 75 mg and shortening hemostasis time from 151.7 s to 50.3 s. The 2, 2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging efficiency reached approximately 80%, and the hydrogel effectively scavenged intracellular reactive oxygen species (ROS) without compromising cytocompatibility or fibroblast activity. This study presents a biomimetic and easily prepared hydrogel platform that integrates pro-coagulant activity, redox regulation, and on-demand injectability, showing translational potential as bioactive wound covering for bleeding control and oxidative microenvironment regulation.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2026
·
IF 5.2
Chao Hao,Keke Xie,Jie He,Guangrui Liu,Anqi Zhu,Xiao Han,Yimeng Yang,Linshan Fan,Guisen Zhang,Jian Zhang
A long-acting Taphalgin-loaded thermoresponsive chitosan hydrogel (TAP-CS/β-GP) depot was developed. • TAP-CS/β-GP rapidly undergoes sol-gel transition within 3 min at 37 °C. • TAP-CS/β-GP showed a first-order release profile with 72 h cumulative release ratio of 93.96%. • TAP-CS/β-GP extended the analgesic duration by 36-fold compared to free TAP. • Subcutaneous TAP-CS/β-GP depot showed a degradation ratio of > 85% within 14 days. The clinical application of Taphalgin (TAP), a tetrapeptide analgesic targeting μ 1 -opioid receptor, was greatly limited owing to fast systemic clearance. In this study, a TAP-loaded in situ injectable thermoresponsive chitosan (CS) hydrogel via β-glycerophosphate (β-GP) crosslinking (TAP-CS/β-GP) was prepared for long-term postoperative analgesia management. The porous microstructure of TAP-CS/β-GP was characterized by scanning electron microscopy (SEM). Rheological analysis further revealed that TAP-CS/β-GP precursor solution showed favorable injectability and shear-thinning behavior, which rapidly approached the solution to gel (sol-gel) transition within 3 min at 37 °C. Furthermore, TAP-CS/β-GP showed a first-order drug release profile with 72 h cumulative TAP release ratio of 93.96 ± 3.18%. The analgesic efficacy of TAP-CS/β-GP was thoroughly evaluated using the rat incisional pain model, mouse acetic acid-induced writhing test and mouse hot-plate test. TAP-CS/β-GP demonstrated fast, potent and sustained analgesia with paw withdrawal threshold (PWT) increase by 3.49-fold at 1 h and effectively prolonged the analgesic efficacy to 144 h for incisional pain. In addition, CS/β-GP demonstrated a degradation ratio of > 85% within 14 days. This TAP-CS/β-GP system provides a prolonged TAP release profile with potent analgesia and favorable safety profile, presenting an alternative strategy for postoperative analgesia. Download: Download high-res image (359KB) Download: Download full-size image
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ACS Applied Electronic Materials
·
2025
·
IF 4.7
Peixuan Wu,Hao Zhuang,Ziyu Qin,Rohan S. Dassanayake,Tawfik A. Khattab,Zeyu Liu,Yang Zhou,Yuanyuan Liu
Conductive hydrogel-based flexible wearable sensors are considered one of the best candidates for next-generation flexible wearable devices due to their flexibility, stretchability, and biocompatibility. However, most of the conventional conductive hydrogels do not possess antimicrobial properties, limiting their application in emerging flexible wearable devices. To address this issue, we successfully developed an antimicrobial and conductive composite hydrogel (QCS-PVA-C-MWCNTs) by the freeze–thawing method, which mainly consists of poly(vinyl alcohol) (PVA), antimicrobial chitosan modified by dimethyloctadecyl-(3-trimethoxysilylpropyl) ammonium chloride (TSA) (QCS), and hydroxylated multiwalled carbon nanotubes (C-MWCNTs). QCS-PVA-C-MWCNTs hydrogels exhibit excellent mechanical properties with high stretchability, excellent self-healing ability (<1 h), and reproducible adhesion performance. QCS-PVA-C-MWCNTs hydrogel-based flexible wearable sensors accurately and quickly monitor human activity (e.g., finger flexion, elbow flexion, mouth opening, and saying “thank you”). The conductivity of QCS-PVA-C-MWCNTs3 hydrogel is ∼7.4 S·m–1, and it also features a fast response (<0.24 s) and high stability (up to 5000 cycles). Moreover, QCS-PVA-C-MWCNTs hydrogels can effectively inhibit the growth of both Escherichia coli (>99.3%) and Staphylococcus aureus (>99.8%) bacterial strains. We envision that this work broadens the avenues for designing multifunctional chitosan-based hydrogels with a wide range of applications in human-computer interaction, sports training, and personal healthcare.
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JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2025
·
IF 3.6
Xiaoguang Liu,Qi Lin,Yi Zhong,Yanling Li,Ji’e Zhang,Yuhua Zhan,Yijia Sun,Ruixia Hou
Catheter-associated urinary tract infections (CAUTIs), the most prevalent hospital-acquired infections globally, remain unresolved despite the development of antimicrobial catheters incorporating silver or antibiotics. To address this challenge, a quaternized chitosan (HTCC)-functionalized catheter was developed through oxygen plasma activation of polyvinyl chloride (PVC) surfaces, followed by polydopamine (PDA) coating and HTCC grafting. This process improves the hydrophilicity of the PVC surface, which is beneficial for reducing urethral mucosal damage in patients, inhibiting the formation of bacterial biofilms, reducing friction and improving patient comfort. This approach eliminated the need for potentially toxic silver nanoparticles and the issue of antibiotic resistance while enhancing surface hydrophilicity. The modified catheter demonstrated superior antibiofilm and antimicrobial efficacy against key uropathogens, including Staphylococcus aureus and Escherichia coli, compared to commercial PVP-urea coated PVC catheters. With its combined advantages in surface wettability, antimicrobial performance, and biocompatibility, this HTCC-based design presents a promising solution for CAUTI prevention and establishes a new paradigm for medical device coatings.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Yubo Liu,Zhenghao Li,Shiwen Xie,Dezhi Lu,Daoyuan Liu,Huiping Xu,Peifeng Wu,Boyu Si,Chaoyi Zhang,Xiangde Lin,Hui Yang
Green hydrogels hold promise for biomedical applications but are limited by weak mechanical properties. Here, we report a chitosan (CS)–reinforced polyvinyl alcohol hydrogel (PVA) fabricated via eco-friendly freeze–thaw cycles, achieving dual enhancement in mechanical strength and antibacterial efficacy. Incorporating 3 wt% chitosan increased compressive strength from 0.36 MPa in pure PVA to 2.92 MPa at 80% strain, while maintaining over 80% recovery after cyclic compression. The porous structure of the fabricated hydrogel and hydrogen-bonded network enabled sustained ciprofloxacin (CIP) release over 72 h. Antibacterial performance against Escherichia coli and Staphylococcus aureus improved significantly with CS addition, reaching 99% efficiency at 3% CS content, while CIP integration achieved complete bacterial eradication (100% efficiency). Synergistic action between the contact-based bactericidal activity of CS and CIP sustained release eliminated colony formation, demonstrating superior inhibition of both Gram-negative and Gram-positive bacteria. This green strategy delivers a mechanically robust, multifunctional hydrogel for infection-resistant biomedical applications.
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Desalination and Water Treatment
·
2024
·
IF 1
Jian Wu,Dajun Ren,Shuqin Zhang,Wenting Liu,Xiaoqin Zhang,Xiangyi Gong
Organic pollutants in aqueous solutions may potentially be adsorbed on biochar. In this study, biochar was derived from the pyrolysis of chitosan at 800°C. The removal rate of 2,4-dichlorophenol (DCP) exceeded 80%. Investigations by Fourier transform infrared spectroscopy and Brunauer– Emmett–Teller indicated that the adsorption of organic pollutants on biochar tends to be a physical process. The optimized pH was 5. All three isotherm models involved (Freundlich, Koble–Corrigan, and Henry) could describe the adsorption process of 2,4-DCP well on chitosan-biochar, which was non-uniform surface adsorption in a diluted solution. The adsorption was an endothermic process. It took 40 min to reach the adsorption equilibrium, and kinetics of the Elovich equation and intraparticle diffusion (IPD) model indicated that the adsorption rate at the rapid adsorption stage was simultaneously controlled by surface diffusion and IPD and that at slow adsorption stage was controlled by surface diffusion. The ionic strengths suggested that electrostatic interaction was not the dominant mechanism during this process.
研究领域:
环境科学
·
环境工程
·
材料科学
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污染控制化学
·
吸附技术
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Jing Luo,Yihui Gu,Yufeng Yuan,Wenjuan Wu,Yongcan Jin,Bo Jiang
As a natural green polymer, chitosan is a promising material for plastic replacement. However, the mutually exclusive strength and toughness severely limit its commercial application, and the improved strength of chitosan-based materials is typically achieved at the expense of elongation or toughness. Herein, inspired by the existed multiple non-covalent interactions in biosynthesized fibers, we successfully fabricated a high-performance lignin/chitosan composite film by constructing sacrificial conjoined-network (hydrogen bonds, electrostatic interaction , etc.), which results in an impressive enhancement in tensile strength (50.2 MPa), elongation (73.6 %), and toughness (2.7 MJ/m 3 ) simultaneously, much superior to the pure chitosan film. In addition, the composite film also demonstrates excellent UV resistance, thermal stability , low oxygen permeability (3.9 cm 3 /(m 2 ·24h‧0.1 MPa)) and food preservation (with no negligible change for grape, apple, and cherry tomato after 5–10 days). Such developed lignin/chitosan with both components from biomass represents a promising alternative for plastic replacement.
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危险品化学品经营许可证（带存储）