ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Nanke Ma,Anqi Wei,Huiling Peng,Lixia Xie,Yuan Jin,Zhengzhi Yin,Guangli Li
Background Chirality plays a critical role in drug efficacy and environmental safety. The antibacterial activity of ofloxacin resides almost exclusively in its S-enantiomer (levofloxacin, LEV), while the R-enantiomer contributes little to therapeutic effects but may pose unnecessary risks. Rapid and reliable methods for enantioselective determination of ofloxacin enantiomers are therefore essential for pharmaceutical quality control, food safety monitoring, and environmental analysis. However, existing electrochemical sensors often suffer from limited enantioselectivity and insufficient sensitivity. To address this challenge, a novel enantioselective electrochemical platform is developed. Results A β-cyclodextrin/cerium-doped copper metal-organic framework/carboxylated multi-walled carbon nanotube composite (β-CD/Ce-doped Cu-MOF/MWCNTs-COOH) was fabricated on a glassy carbon electrode. The sensor achieves discrimination of ofloxacin enantiomers with an I L /I D ratio of 3.39. DFT calculations at pH 4.0 reveal that β-CD binds LEV with higher adsorption energy (−63.8 kJ/mol) than DEX (−58.3 kJ/mol), confirming the superior response for LEV originates from stereospecific inclusion. Quantitative analysis of LEV shows two linear ranges (0.03–1 μM and 1–10 μM) with a low detection limit of 0.01 μM. The sensor also enables accurate determination of LEV percentage in enantiomer mixtures across 0–100%. Excellent selectivity against common interferents, good reproducibility (RSD = 0.98%), repeatability (RSD = 1.26%), and long-term stability (95.2% retention after 21 days) are demonstrated. Practical applicability is validated by detecting LEV in commercial eye drops, honey, and tap water with satisfactory recoveries (96.0–108.0%). Significance and novelty This work presents the first application of Ce-doped Cu-MOF/β-CD/MWCNTs-COOH composites for the enantioselective electrochemical sensing of ofloxacin, a chiral fluoroquinolone antibiotic. The synergistic combination of high conductivity, abundant catalytic sites, and stereospecific host-guest recognition provides a generalizable strategy for high-performance enantioselective sensing, with promising applications in pharmaceutical, food, and environmental analysis.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Faman Lin,Jiaqi Geng,Yanxin Lv,Zhitan Huang,Daniel Scherman,Shuhai He,Hongji Li,Tingting Sun,Wei Sun
Pt@COOH-MWCNT/PVA/AM hydrogel is synthesized by in situ gelation method. • Hydrogel modified electrode is used to sensitive electrochemical analysis of BPA. • Good properties of conductivity, antibacterial and salt-resistant are realized. • The sensor has a wide range of 0.05–1000.00 μM and a low LOD of 0.045 μM. Bisphenol A (BPA), which is extensively employed in plastics and food-contact products, poses serious hazards to the ecological environment and human health because of its endocrine disruptor property. Owing to its wide usage and environmental persistence, sensitive, selective and rapid BPA detection is urgently required, particularly in seawater. In this work, a conductive hydrogel prepared by anchoring Pt nanoparticles (NPs) onto carboxyl-functionalized multi-walled carbon nanotubes (COOH-MWCNT) was used to modify a glassy carbon electrode (GCE) for BPA electrochemical detection. The morphology and structure of the resulting composite were characterized, which revealed a dense, three-dimensional porous conductive network with fast electron transport ability and good mechanical stability. The incorporation of Pt@COOH-MWCNT significantly improved both the electrical conductivity and the electrocatalytic oxidation performance toward BPA. The fabrication and electrochemical detection parameters were optimized. Under optimal conditions (0.1 M phosphate buffer solution, pH 6.0), the sensor exhibits a BPA linear response range of 0.05–1000.00 μM with a detection limit of 0.045 μM, along with superior anti-interference, good stability, reproducibility (RSD = 0.9%), excellent salt tolerance, and antibacterial activity. When applied to real seawater samples, the recoveries were ranged from 97.50% to 106.00% with a relative standard deviation below 3.5%, confirming the sensor's favorable accuracy and reliability. The proposed sensor integrates robust structural integrity, enhanced conductivity, high catalytic activity, cost-effectiveness, and antibacterial performance, which offers a new strategy for on-site rapid monitoring of BPA in seawater environments with great application potential. The detection of bisphenol A (BPA) in seawater remains challenging due to complex matrices and the lack of simple, low-cost sensing platforms, as conventional electrochemical sensors often involve tedious fabrication or suffer from limited performance. Herein, a Pt@COOH-MWCNT/PVA/AM conductive hydrogel is fabricated via a straightforward in situ gelation strategy, providing a facile and cost-effective approach. Exploiting the high conductivity of COOH-MWCNT, the electrocatalytic activity of Pt nanoparticles, and the porosity, antibacterial property, and salt tolerance of the PVA/AM matrix, the constructed sensor achieves sensitive BPA detection over a wide linear range (0.05–1000 μM) with a low detection limit (0.045 μM), along with good reproducibility, anti-interference capability, and stability. Satisfactory recoveries (97.50%–106.00%) obtained in real seawater samples confirm its analytical reliability. This work offers a promising strategy for developing robust, low-cost electrochemical sensors suitable for on-site monitoring of BPA in complex marine environments. Download: Download high-res image (144KB) Download: Download full-size image
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ANALYST
·
2025
·Vol. 150
·期 14
·3217-3224
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IF 3.3
Jie Jiang,Xuening Wang,Kai Yu,Zhiping Sun,Qianyun Yu,Yang Chen
In order to achieve rapid extraction and sensitive detection of capsaicinoids, this study combined glass bead-assisted ultrasound extraction with a Bi2S3/rGO/MWCNT-COOH-modified screen-printed electrode. By integrating ethanol–water solvents and glass beads, the ultrasonic cavitation effect was enhanced, reducing the extraction time from 50 minutes to 22 minutes while maintaining high efficiency. The composite-modified SPE exhibited superior electrochemical performance, achieving a detection limit of 26 nM through differential pulse voltammetry (DPV). The response surface methodology optimized extraction parameters and real-sample validation demonstrated high reliability (recovery: 94.70–110.50%) and consistency with HPLC results. This approach offers a rapid, eco-friendly solution for on-site analysis of capsaicinoids in food safety and quality control applications.
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高影响因子
Current Research in Food Science
·
2025
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IF 7
Hai Chi,Yue Xiao,Houqi Ning,Xingzhong Zhang,Hongrui Chen,Jie Tang,Xuefei Wen
This study established a unified electrochemical sensing platform for the ultra-sensitive and rapid detection of foodborne pathogens. Targeting three representative pathogenic bacteria— Staphylococcus aureus , Escherichia coli , and Salmonella typhimurium —a composite sensing interface was fabricated by integrating MWCNT-COOH with MOF-818. Highly specific aptamers were directionally immobilized onto the MWCNT-COOH/MOF-818 composite surface through thiol-ene click chemistry, yielding an electrochemical biosensor with superior performance. Experimental results revealed detection limits of 3, 6, and 4 CFU mL −1 for the three target bacteria, respectively. Moreover, the sensor displayed strong detection capabilities in authentic food samples (pork paste). This detection strategy by integrating sample recognition and signal transduction within a single interface can be generalized to multiple pathogens via aptamer substitution, offering a novel technical approach for on-site rapid screening in food safety. This platform holds considerable potential for the prevention and control of foodborne diseases.
研究领域:
生物传感器
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食品安全
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纳米技术
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分析化学
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微生物学
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电化学
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材料科学
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高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 8
·1-16
·
IF 5.3
Yan Ruixue,Guo Hao,Yang Zeyun,Niu Wenting,Yan Yu,Ma Jianpeng,Wang Mingyue,Yang Wu
A sensitive electrochemical sensor was constructed for tyrosine detection by collaborating a highly conductivity, excellent electrocatalysis and large surface of nitrogen-rich porous covalent organic framework in situ grown on three-dimensional conductive carboxylated multi-walled carbon nanotubes network and catalytic activity of triangular silver nanosheets. The prepared electrochemical sensing platform exhibited satisfactory results for detection of tyrosine with a wide linear range of 0.6–280 μM and a low detection limit of 0.017 μM, which were significantly superior to those of most existing electrochemical methods. At the same time, the developed sensor was successfully applied to the detection of tyrosine in real samples including human serum and urine and displayed high recoveries, good stability, reproducibility, and anti-interference ability. This study not only provides a novel sensing platform for tyrosine monitoring but also offers an innovative design concept for leveraging multifunctional nanocomposites in biosensing applications. Graphical
研究领域:
分析化学
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材料科学
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生物化学
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纳米技术
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电化学
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2024
·
IF 4
Xiaoxue Liu,Yangping Wen,Wentao Hu,Xinyu Lu,Lili Chen,Li Zhao,Qian Zeng,Huiyi Tang,Yanping Hong,Kaijie Tang
The label-free immunosensing technique is highly valued for its sensitivity and specificity, and advantages of simple preparation, fast detection (one-step), and rapid signal response. However, the sensitivity, stability, and specificity of this technique not only depend on the performance of antibodies, but also on the immunosensing interface of the bare glassy carbon electrode (GCE). This includes factors such as electrical conductivity , biocompatibility , and antibody loading capacity. In this study, carboxyl multiwalled carbon nanotubes-ferrosoferric oxide-graphene oxide (COOH-MWCNTs-Fe 3 O 4 -GO) was screened as the modified material of GCE to create an ideal immunosensing interface for the biological reaction between antibody-sulfadimidine (anti-SM2) and SM2. The structure of both nanomaterials and the immunosensor were characterized. The nanohybrid exhibited a uniform interwoven structure of laminar and tubular components. This unique structure allows for a higher capacity for antibody loading. Based on this, a novel electrochemical immunosensor was constructed using COOH-MWCNTs-Fe 3 O 4 -GO/GCE, which exhibited a high anti-SM2 loading capacity and a rapid detection time of 30 min. The immunosensor exhibited a linear detection range of 0.01–100 ng/mL for SM2, with a limit of detection (LOD) of 0.003 ng/mL and a limit of quantification (LOQ) of 0.01 ng/mL. Additionally, satisfactory recoveries ranging from 94.40% to 109.00% were achieved in crayfish samples, with a relative standard deviation (RSD) of 4.97–8.64%. A novel immunosensors for highly sensitive detection of SM2 has been developed, which may provide an alternative idea for determination of SM2 in crayfish and other seafood.
研究领域:
食品科学
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分析化学
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生物技术
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CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Yuan Gao,Peng He,Jingwen Yang,Bo Liu,Qiong Zhang,Qi Zhou,Hanlu Xu,Rongli Jiang,Zhongran Dai,Shaorong Wang
We focus on optimizing acid-base interactions and hydrogen bonding networks to achieve enhanced proton conductivity under low relative humidity (RH) and high temperature. By functionalizing UiO-66-(COOH) 2 with glutamic acid (Glu) and lysine (Lys), we generate Glu-UiO-66-(COOH) 2 and Lys-UiO-66-(COOH) 2 . These modified materials are subsequently incorporated into chitosan (CS) to produce the composites Glu-UiO-66-(COOH) 2 @CS and Lys-UiO-66-(COOH) 2 @CS. The successful incorporation of amino acids and cross-linking between -COOH and -NH 2 groups in the composites, confirmed by FTIR and PXRD analyses, significantly enhances the structural integrity and durability by strengthening the network, and reducing polymer chain mobility. Proton conductivity assessments reveal that Lys-UiO-66-(COOH) 2 @CS-7 exhibits a remarkable conductivity of 0.022 S/cm at 100 % RH and 363 K, outperforming Glu-UiO-66-(COOH) 2 @CS-7. The lower activation energy ( E a ) of 0.28 eV for Lys-UiO-66-(COOH) 2 @CS-7, compared to 0.336 eV for Glu-UiO-66-(COOH) 2 @CS-7, highlights the significant improvement in intramolecular acid-base interactions and hydrogen bonding. Furthermore, Lys-UiO-66-(COOH) 2 @CS-7 maintains notable proton conductivity at 43 % RH, with an E a of 0.216 eV, demonstrating its efficacy in low-humidity conditions. These findings underscore the profound impact of amino acid modifications and cross-linking on proton conductivity by reinforcing acid-base interactions, hydrogen bonding networks, and proton transfer efficiency.
研究领域:
材料科学
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化学工程
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EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
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2014
·Vol. 2014
·期 20
·3172-3177
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IF 2.965
Zhiming Chen,Zhirong Geng,Zhiyang Zhang,Lianbing Ren,Tingxian Tao,Renchun Yang,Zuxiang Guo
Graphical Core–shell magnetic Fe 3 O 4 @C nanoparticles are functionalized with sulfonic and carboxylic acid groups and employed to capture heavy metal ions in aqueous media. The magnetic Fe 3 O 4 @C nanoparticles can be easily separated with an external magnet and possess rapid removal kinetics, high adsorption capacities, and removal efficiencies for Pb 2+ , Hg 2+ , and Cd 2+ ions from aqueous solution. Core–shell magnetic Fe 3 O 4 @C nanoparticles functionalized with sulfonic and carboxylic acid groups were synthesized and employed to capture heavy metal ions in aqueous media. The Fe 3 O 4 cores possess unique magnetic properties for adsorbent separation, and the –SO 3 H and –COOH groups attached to the surface of the carbon shells determine the efficiency of heavy metal ion removal. Batch adsorption experiments showed that Pb 2+ , Hg 2+ , and Cd 2+ ions can be completely and quickly removed by the Fe 3 O 4 @C nanoparticles. The equilibrium was established within 5 min, and the maximum adsorption capacities of the Fe 3 O 4 @C nanoparticles toward Pb 2+ , Hg 2+ , and Cd 2+ ions were 90.7, 83.1, and 39.7 mg/g, respectively. The removal efficiencies were 96.3, 98.1, and 93.8 % for Pb 2+ , Hg 2+ , and Cd 2+ ions, respectively. This work provides a facile and general approach to synthesize magnetic functional nanocomposites for wastewater treatment.
研究领域:
环境科学
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材料科学
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2016
·
IF 5.31
Xiaoling Zhang,Mingbao Feng,Liansheng Wang,Ruijuan Qu,Zunyao Wang
Recently, the toxicity of sunscreen has received extensive attention due to their potential endocrine disrupting effect. In the present study, nitrogen and sulfur co-doped multi-walled carbon nanotubes loaded CuFe 2 O 4 (NS-CNTs/CuFe 2 O 4 ) catalyst was rationally designed and synthesized by co-precipitation method for the degradation of 2-phenylbenzimidazole-5-sulfonic acid (PBSA, a typical sunscreen addition). The catalyst was fully characterized by scanning electron microscope, transmission electron microscope, X-ray diffraction, Fourier transform infrared spectroscopy, nitrogen gas uptake, and X-ray photoelectron spectroscopy. Then the kinetics, pathways and mechanisms of catalytic degradation of PBSA were studied in NS-CNTs/CuFe 2 O 4 activated peroxymonosulfate (PMS) solution. The catalyst showed high catalytic activity, stability and reusability in PBSA removal. The results of electron paramagnetic resonance (EPR) and quenching experiments suggested that sulfate radicals (SO 4 − ) predominated in the activation of PMS by NS-CNTs/CuFe 2 O 4 . The synergistic effect between CuFe 2 O 4 and NS-CNTs was proposed in PMS activation. In addition, eight degradation intermediates of PBSA were identified by liquid chromatography mass spectrometry (LC–MS), and degradation pathways were further proposed. Overall, this study provides insights of PBSA removal by NS-CNTs/CuFe 2 O 4 activated PMS at ambient temperature.
研究领域:
环境科学
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材料科学
·
化学工程
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2021
·Vol. 414
·期 2
·1129-1139
·
IF 4.157
Zhang Xue,Liao Xiaoning,Wu Yongfa,Xiong Wanming,Du Juan,Tu Zhui,Yang Wuying,Wang Dan
A label-free electrochemical immunosensor has advantages of real-time and rapid detection, but it is weak in detection of small molecular toxins such as aflatoxin B 1 (AFB 1 ). The greatest obstacle to achieving this is that small molecules bound to a common immunosensing interface cannot interfere with electron transfer effectively and the detection signal is so weak. Therefore, a sensitive electrochemical immunosensing interface for small molecules is urgently needed. Here, we employed functionalized black phosphorene (BP) as electrode modification materials and anti-AFB 1 nanobody (Nb) as a biorecognition element to construct a very sensitive immunosensing interface towards small molecular AFB 1 . The BP functionalized by carboxylic multi-walled carbon nanotubes (MWCNTs-COOH) via P–C bonding behaved with a satisfactory stability and good catalytic performance for the ferricyanide/ferrocyanide probe, while the small-sized Nb showed good compatibility with the functionalized BP and also had less influence on electron transfer than monoclonal antibody (mAb). Expectedly, the as-prepared immunosensing interface was very sensitive to AFB 1 detection by differential pulse voltammetry (DPV) in a redox probe system. Under optimized conditions, a linear range from 1.0 pM to 5.0 nM and an ultralow detection limit of 0.27 pM were obtained. Additionally, the fabricated immunosensor exhibited satisfactory stability, specificity, and reproducibility. The strategy proposed here provides a more reliable reference for label-free sensing of small molecules in food samples. Graphical abstract
研究领域:
分析化学
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纳米技术
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食品科学
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生物技术
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高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2022
·
IF 6.76
Xinling Zhang,Ning Yuan,Shuo Xu,Yi Li,Qibao Wang
The removal of organic pollutants was examined by new zeolitic imidazolate framework-8/carboxyl-functionalized multi-walled carbon nanotubes (ZIF-8/MWCNTs-COOH) nanoadsorbents, which were prepared via controlling the reaction sequence of MWCNTs-COOH with the precursors of ZIF-8. Structural morphology and chemical composition characterizations confirmed the successful preparation of ZIF-8/MWCNTs-COOH nanoadsorbents. The obtained samples manifested a preferable adsorption capacity for Congo red with the maximum adsorption capacity of 1185.58 mg g −1 with an adsorption removal rate of 97.93% at equilibrium adsorption. Further analyses indicated that the adsorption process conformed to the pseudo-second-order kinetic model and Langmuir adsorption isotherm. The thermodynamic analyses were depicted as endothermic, entropy-increasing, and spontaneous. The effects of pH value, interfering ions, and dosage on the adsorption properties were systematically explored. The nanoadsorbent can be expediently reused for eight cycles without a prominent reduction in adsorption activity. The improved performance and high reusability can be ascribed to the increasing specific surface, the presence of electrostatic interaction, hydrogen bonding, and π–π interaction between ZIF-8/MWCNTs-COOH and organic molecules. In addition, the prepared composites also showed a better adsorption performance for tetracycline with the equilibrium adsorption capacity of 471.22 mg g −1 compared to pure ZIF-8 and MWCNTs-COOH.
研究领域:
环境科学
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材料科学
·
化学工程
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高影响因子
POLYMER COMPOSITES
·
2023
·
IF 5.2
Chengde Liu,Pengxin Mei,Xitong Cheng,Cheng Liu,Nan Li,Xigao Jian
Improving the interfacial adhesion of carbon fiber (CF)/polymer composite is an urgent demand to enhance its mechanical properties. A kind of poly(aryl ether ketone) with carboxyl groups (PAEK-COOH) was newly synthesized. PAEK-COOH is similar to the thermal properties of PPEK matrix. Hydroxyapatite (HAp) was easily dispersed in an NMP solution containing PAEK-COOH. Different kinds of hybrid sizing agents were obtained for preparing the prepreg through the solution impregnation. The hot-pressing method was employed to produce the laminated composites. Flexural strength, flexural modulus and interlamellar shear strength (ILSS) of 0HP@CF/PPEK composites were improved by 8.8%, 17.3%, and 14.7%, respectively, in comparison to desized CF/PPEK. The interface bonding between CF and PPEK was improved by the addition of PAEK-COOH sizing agent. Meanwhile, compared with desized CF/PPEK laminates, flexural strength, flexural modulus and ILSS of 5HP@CF/PPEK composites were enhanced by 63.5%, 87.4%, and 40.9%, respectively. The crack propagation path became dispersed and the stress was effectively absorbed when the sizing agent containing nano-hydroxyapatite particles. By characterizing and reconstructing the transverse and longitudinal fracture in composite materials, the failure process of the composites under the action of stress was explained, and the interface theories of CF reinforced polymer were further explored. Highlights A kind of polyaryl ether ketone containing carboxyl functional group (PAEK-COOH)was newly synthesized. HAp was distributed in the polymer sizing agent to obtain a HAp/PAEK-COOH hybrid sizing agent. The interfacial adhesion of CF/PPEK composite was greatly improved by the hybrid sizing agent.
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