SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Wenjing Li,Bi Lin,Bixiao Li,Peifu Zhang,Ziyue Ju,Anees A. Ansari,Ruichan Lv
Nanorobots, with miniature size, wireless operation, and flexible mobility, can access narrow spaces and are widely used in biomedicine. High-precision transport is vital for targeted drug delivery, disease diagnosis, and treatment, yet current research has limitations like insufficient single-imaging diagnosis and active tumor targeting. In this research, a magnetic nanorobot platform is proposed, combining magnetic ferric oxide substrate with rare earth nanoparticles (RENPs). This magnetic nanorobot features multi-modal imaging including NIR II fluorescence, MRI, and PA with high moving target effect (<5 s). After conjugated with antibodies against MET and VEGF, this platform enables multi-molecular targeting. Under an external magnetic field, the dual-targeting (active and physical magnetic) allows in vitro and in vivo precise tumor cell targeting with tumor imaging. Moreover, its NIR II luminescence enables enhanced real-time temperature detection (Region: 24.6–41.5℃). Especially, the deep learning allows NIR II imaging to simultaneously perform increased fluorescence imaging for surgical boundary definition and temperature sensing display (R 2 = 0.973, RMSE = 1.50℃). With high penetration and spatial resolution, this proposed magnetic/rare earth hybrid nanorobots holds great promise for precision biomedicine.
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SENSORS AND ACTUATORS A-PHYSICAL
·
2026
·
IF 4.9
Esmaeil Heydari,Amirhossein Moradi,Javad AmirAhmadi,Mohammad Moeini,Hossein Zare-behtash,Gongxun Bai
Upconversion nanoparticles (UCNPs) hold strong promise for the development of durable, contactless, and implantable photonic sensors owing to the deep tissue penetration of their near-infrared (NIR) excitation source and minimal photodamage by NIR light. Here, we report a Ba 2 ErF 7 @Ba 2 La 4 F 7 @Ba 2 Yb 0.98 F 7 Tm 0.02 @Ba 2 La 4 F 7 UCNP-based glucose sensor that functions under 980 nm NIR laser excitation. The sensor is comprised of two layers, including an oxygen-sensitive bottom layer of PtTFPP-UCNPs doped in a xerogel film, and a top layer of glucose oxidase (GOx) immobilized within a hydrogel matrix. Excitation of oxygen-sensitive platinum (II) tetrakis(pentafluorophenyl)porphyrin (PtTFPP) complex is mediated by luminescence resonance energy transfer (LRET) from UCNPs. Glucose detection is based on oxygen consumption during the GOx-glucose reaction, which modulates the phosphorescence lifetime of PtTFPP. The glucose level is obtained from the slope of the time-dependent phosphorescence lifetime response instead of conventional end-point phosphorescence lifetime measurements, providing faster glucose quantification. The slope varies linearly with glucose concenrtation, which covers the physiologically relevant levels for detecting abnormalities in diabetic patients. Optical characterization of the sensors revealed a sensitivity of 13.4E-12 µs·dL·mg⁻¹ ·min⁻¹ , a limit of detection (LOD) of 11 ± 1.45 mg/dL, short-term and long-term instabilities of 0.25 ± 0.02 % and 1.6 ± 0.9 %, respectively, and a reproducibility of 1.4 %. An in vitro cytotoxicity assay using human dermal fibroblasts (HDFs) demonstrated 94 ± 7 % cell viability after 24 h incubation, confirming excellent biocompatibility of the sensor.
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Frontiers in Chemistry
·
2026
·
IF 4.2
Xuesheng Hu,Lu Han,Yiying Tan,Peitong Wu,Yajing Li,Wanjie Liu,Jiaming Shen,Yishan Li,Ming Yang,Chunnan Li,Jiaming Sun
Non-alcoholic fatty liver disease (NAFLD) represents a chronic liver disorder with widespread global prevalence, primarily attributed to hepatic lipid accumulation, oxidative stress, and inflammatory responses. In the realm of traditional Chinese medicine, Ganoderma lucidum is predominantly utilized for its hepatoprotective properties. The objective of this study was to isolate and identify novel bioactive compounds capable of mitigating hepatic fat accumulation. An in vitro steatosis model was established using oleic acid-induced HepG2 cells to evaluate the total triglyceride (TG) content across various components. Fractionation of the compounds was guided by the observed reduction in TG content, employing multiple chromatographic techniques to successfully isolate ten Ganoderma triterpenes. Structural elucidation was achieved through 1D and 2D NMR spectroscopy, supplemented by additional spectroscopic methods. This investigation led to the identification of two previously unreported lanostane-type triterpenes (1–2) alongside eight known analogues (3–10). Compound 1 and 2 exhibit structural distinctions from the other compounds, primarily in the substituents at positions C-3, C-7, and C-15, as well as in the spatial orientation of these substituents. In vitro experiments were conducted to assess the efficacy of various compounds in inhibiting lipid accumulation. Compound 1-5 demonstrated a significant reduction in TG levels within the OA-induced HepG2 cell model ( p < 0.05). In comparison to the model group, Compound 1 demonstrated a moderate lipid-lowering effect, (2.11 mmol/gprot vs. 2.70 mmol/gprot, p < 0.003). Conversely, Compound 2 exhibited a significantly more pronounced lipid-lowering effect, (1.27 mmol/gprot vs. 2.70 mmol/gprot, p < 0.0001). Furthermore, when compared with the positive control drug, the lipid-lowering efficacy of Compound 2 was significantly superior to that of Compound 1. Furthermore, the application of network pharmacology, molecular docking, and molecular dynamics simulations elucidated the mechanism of action underlying the effects of methyl ganoderenic acid A(2).
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ANALYTICAL CHEMISTRY
·
2026
·
IF 6.7
Jiabao Guo,Lei Xu,Jing Wang,Xinyu Miao,Xiawei Xu,Aochi Liu,Li Sun,Yujiao Xie,Zhiwei Hou,Tianxiang Chen,Aiguo Wu,Jie Lin,Tianan Jiang
Serous effusions, including pleural effusion and ascites, commonly occur in advanced cancers like lung and ovarian carcinomas. Detecting tumor cells in these effusions is crucial for assessing cancer metastasis. However, clinical methods mainly include cytological examination, which has limited sensitivity, and complex cell block technology that requires large volumes of serous effusion. Surface-enhanced Raman spectroscopy (SERS), with its high sensitivity and noninvasive nature, has emerged as a crucial tool for liquid biopsies. Building on this technology, a novel SERS bioprobe was specifically designed for the precise identification and capture of tumor cells in serous effusions, utilizing a composite material. The SERS bioprobes offer strong SERS enhancement, excellent spectral reproducibility, and molecular targeting, thereby enhancing detection specificity. Furthermore, SERS classification models were established to categorize samples based on tumor cell concentrations in serous effusions, enabling semiquantitative diagnostic capability. Notably, machine learning-assisted analysis enables rapid processing and classification of numerous Raman spectra and thorough feature extraction and greatly improves the SERS bioprobe’s diagnostic accuracy. Consequently, the combination of SERS bioprobes and machine learning provides a rapid and effective detection method that overcomes the low sensitivity of conventional cytological detection in serous effusions and enables assessment of tumor cell concentration ranges within these fluids.
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Foods
·
2026
·Vol. 15
·期 3
·479
·
IF 5.1
Baizhi Cen,Juge Liu,Mengyuan Tan,Bo Wang,Lu Gao,Zhenquan Yang,Genxi Zhang,Tao Zhang,Xuechao Xu
In this study, a silver-based metal–organic framework (Ag-MOF) nanozyme was synthesized for the synergistic eradication of drug-resistantSalmonellaenteritidisin food matrices. Ag-MOF exhibits multiple enzyme-like activities, namely oxidase (OXD)-, peroxidase (POD)-, and superoxide dismutase (SOD)-like activities. It demonstrated excellent antibacterial and antibiofilm activities against erythromycin- and chloramphenicol-resistantS. enteritidisstrains (N29 and P23). Specifically, treatment with 20 mg mL−1Ag-MOF resulted in nearly complete eradication ofS. enteritidisin in vitro suspension assays, including 1 × 107CFU mL−1N29 strain and 6 × 106CFU mL−1P23 strain. Moreover, treatment with 1 mg mL−1Ag-MOF led to 80~90% biofilm inhibition ofS. enteritidis. Mechanistic investigations revealed that Ag-MOF effectively interacted with amino-rich structures on the bacterial surface (such as membrane proteins and peptidoglycan components), generated abundant reactive oxygen species (ROS), released Ag+ions, and depleted intracellular glutathione, which collectively disrupted cell membrane integrity and induced severe leakage of intracellular proteins and nucleic acids. Importantly, Ag-MOF maintained high antibacterial efficacy in complex simulated food matrices (pork, milk, and egg shell). Overall, this study offers key insights into enzyme-mimicking antibacterial materials and a promising strategy to combat multidrug resistant foodborne pathogens.
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APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Wanwan Wu,Linjie Song,Yinqi Qiao,Yan Bai,Xue Liu,Haiyan Li,Dongbin Dang
Developing efficient photocatalysts for the conversion of CO 2 into value-added chemicals is considered as an ideal strategy to handle the energy crisis and environmental pollution. Among the numerous candidate materials, lead-free perovskite Cs 3 Bi 2 Br 9 has attracted significant research interests in CO 2 photoreduction because of its excellent reducing power and controllable product selectivity. In this work, we developed a novel Cs 3 Bi 2 Br 9 /Ta 2 O 5 composite via the in-situ growth of Cs 3 Bi 2 Br 9 on the porous Ta 2 O 5 , which exhibits excellent dual functionalities of CO 2 capture and conversion. The optimized sample T2 achieved a CO photoreduction yield of 413.45 μmol g −1 h −1 without adding any sacrificial agents, which is 4.7 and 22.3 times higher than that of pure Cs 3 Bi 2 Br 9 and Ta 2 O 5 , respectively. The markedly improved photocatalytic performance arises from a type-II heterojunction charge transfer pathway generated between Cs 3 Bi 2 Br 9 and Ta 2 O 5 , which drives the highly efficient separation and transfer of charge carriers, as confirmed by the enhanced photocurrent response and quenched PL intensity. Furthermore, the achieved composite also exhibited remarkable stability, as evidenced by the well-maintained structural integrity of the material after a 24-hour cycling test. This study provides key insights for developing novel lead-free perovskite-based photocatalysts, which has significant scientific and application value for achieving carbon neutrality goals.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Ru Yan,Hongyang Wang,Rui Dong,Ping Wen,Mingjin Fan
Conventional solvent-free nanofluids hold promise as lubricants but often face challenges in intricate preparation and unadjustable performance. Herein, we developed a facile one-pot strategy for synthesizing MoS 2 quantum dots (QDs) nanofluids (MoNFs) via a coordination-confined growth approach, which features cyan-fluorescent with an average size of 3.8 nm, homogeneously dispersed in a tailored ionic liquid matrix. The resulting MoNFs exhibit tunable viscosity and desirable shear-thinning behavior. When evaluated as lubricants, the optimal formulation (3MoNFs) decreases wear volume by 73.8% compared to the base fluid. Comprehensive characterization of worn track reveals a triplex synergistic lubrication integrating an electric-double-layer film, tribochemical reaction film and solid-like nanofluid layer, concurrently assisted with repairing pre-existing wear scars. Impressively, blending merely 0.7 wt% 3MoNFs into commercial SN 0 W-30 engine oil enhances its anti-wear performance by 47.5%, demonstrating outstanding potential for high-performance lubricants.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Yue Feng,Puxiang Zhao,XueChang Pei,Di Liu,Pengfei Ma,Chuanxi Wang,Mingxian Liu
Diabetic wounds frequently develop infections and impaired healing due to the hyperglycemic microenvironment, creating a need for dressings with combined antibacterial and tissue-regenerative functions. Here, the lumens of halloysite nanotubes (HNTs) were employed for confined in-situ synthesis of silver nanoparticles (Ag@HNTs), which were then incorporated into a chitosan matrix by solution mixing and freeze-drying to produce porous Ag@HNTs-CS sponges. The lumen-confined synthesis generated uniformly distributed Ag nanoparticles in the HNT lumens, which reduced aggregation and direct cell contact, thereby lowering toxicity and enabling sustained Ag + release. The composite exhibited triple antibacterial functionality, combining bactericidal effects mediated by chitosan, Ag + sustained release, and enhanced photothermal activity under 808 nm irradiation, strongly inhibiting E. coli and S. aureus . In a diabetic rat model with infected full-thickness skin defects, these sponges significantly promoted wound healing. Mechanistically, the sponges reduced TNF- α , increased IL-10 and VEGF, mitigating inflammation while enhancing neovascularization and collagen deposition. The confined-synthesis of metal nanoparticles within the HNT lumens and incorporation into a biopolymer matrix ensures sustained metal ion release, high photothermal performance and bioactivity, which offer a promising strategy for infected wound management.
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RSC Advances
·
2026
·Vol. 16
·期 8
·6844-6855
·
IF 6.1
Xinqin He,Mengjie Yang,Xia Zhang,Bin Qiu,Hong Jiang
Early detection of endometrial cancer remains challenging because of the lack of sensitive and specific diagnostic methods. This study develops a near-infrared (NIR)-activatable sensing platform with an AND logic gate to simultaneously detect miR-21 and miR-155, two promising endometrial cancer biomarkers. The sensing platform integrates acid-sensitive zeolitic imidazolate framework-8 (ZIF-8)-coated upconversion nanoparticles (UCNP@ZIF-8) with ternary DNA strands, consisting of a BHQ2-modified long strand (S2), a Cy5-labelled short strand (S3), and a photocleavable switch-bearing strand (S1). In a weakly acidic environment, the ZIF-8 shell decomposes to release UCNPs and DNA strands. Under 808 nm excitation, the UCNPs convert NIR light to ultraviolet or visible emission, cleaving the photocleavable linkers on S1 and exposing the toehold domain. The target miRNAs subsequently initiate a toehold-mediated strand displacement reaction, simultaneously displacing S1 and S3, thereby restoring Cy5 fluorescence. The biosensor demonstrated excellent sensitivity, with detection limits of 0.28 nM for miR-21 and 0.35 nM for miR-155. Validation in serum samples revealed recovery rates of 92–103.08%, confirming its potential for clinical application in complex biological environments.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.7
Wanying Zhang,Kaihuai Zhuo,Jie Chen,Tongtong Wang,Xuanyang He,Mengjie Li,Weilin Gao,Yiran Zhao,Xue Yang,Zhuoyin Peng,Xiaoyu Zhang,Yingwei Wang,Keqiang Chen,Guogang Li
Surface ligands are crucial for perovskite quantum dot (PQD) optoelectronics. However, long alkyl chains limit charge transport, while short chains destabilize their soft lattice, presenting a stability–mobility dilemma. Moreover, surface-bound protonated primary amines are susceptible to deprotonation, accelerating performance decay and structural collapse. In this work, we introduced tetrabutylphosphonium bromide (TBPB) as a surface passivation ligand to overcome these limitations. TBPB combines minimal molecular polarity—enabling a short chain for superior charge transport—with a fully coordinated phosphonium center that resists deprotonation and passivates halogen vacancies. This yields quantum dots with near-unity PLQY and robust stability, leading to LEDs achieving a maximum external quantum efficiency (EQE) of 24.28% and luminance of 122,786 cd m −2 , far surpassing control devices. Further shortening the ligand chain increases EQE to 27.89% but at the cost of severe luminance loss, underscoring the delicate balance in ligand engineering.
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Advanced Optical Materials
·
2026
·
IF 7.2
Jialong Xu,Yubiao Yue,Zhishan Chen,Hongqiang Zhu,Shaoan Zhang,Yiqing Chen,Huiwang Lian,Yuzhen Wang,Jia Xu,Linhai Li,Yang Li
Rapid, instrument-free detection of mercury ions (Hg 2+ ) is critical for addressing environmental emergencies, yet current methods face limitations in poor portability and sensitivity. Herein, a deep learning-optimized paper-based kit that incorporates controllable turn-off fluorescence of metal halide perovskite for instrument-free time-critical Hg 2+ detection by the dynamic quenching mechanism and ensures visual discernment at 2 ppb, achieving a 1000-fold sensitivity improvement over commercial strips is presented. Furthermore, a smartphone app powered by the deep learning model (MobileViT) further optimizes sensitivity, achieving ultrasensitive quantification (0.11 ppb limit of detection) across a 0.2–200 ppb linear range (R 2 = 0.987) with 98% overall accuracy, and the whole detection is completed only within 5 min. This approach of instrument-free time-critical Hg 2+ detection anticipates a new paradigm for rapid and on-site Hg 2+ monitoring in environmental and industrial settings.
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Solar RRL
·
2026
·Vol. 10
·期 1
·e202500927
·
IF 4.7
Yu Li,Guo Lu,Jieyu Zheng,Jie Chen,Shuaibing Wang,Mengmeng Ma,Zhijie Wang,Aiwei Tang
Ensuring broad-spectrum visible-light absorption and efficient electron extraction is essential for enhancing the efficiency of photocatalytic hydrogen production. To achieve this, manipulating carrier dynamics through cocatalyst heterojunction engineering has attracted considerable concern. However, conventional narrow-bandgap Cu–In–Zn–S (CIZS) nanocrystals (NCs) typically exhibit limited photocatalytic activity due to severe exciton annihilation. Herein, two-dimensional (2D) CIZS nanobelts (NBs) were coupled with Ni 9 S 8 cocatalyst to construct a library of CIZS/Ni 9 S 8 Schottky heterojunctions synthesized via a combined colloidal one-pot and hot-injection strategy. As anticipated, the CIZS/2.0%Ni 9 S 8 heterojunction displayed the optimal photocatalytic hydrogen evolution activity of 2.75 mmol g −1 h −1 , ≈3.31 times higher than that of pristine CIZS NBs (0.83 mmol g −1 h −1 ). Experimental results uncovered that the enhanced photocatalytic performance originated from the formation of the CIZS/2.0%Ni 9 S 8 Schottky heterojunction, which facilitated efficient charge transfer from CIZS NBs to Ni 9 S 8 and hindered the return of electrons. Moreover, Ni 9 S 8 serves as active catalytic sites, significantly accelerating surface proton reduction reactions. This study provides valuable insights into the rational design and precise synthesis of colloidal multinary Cu-based chalcogenide heterojunctions for efficient photocatalytic energy conversion.
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