JOURNAL OF ETHNOPHARMACOLOGY
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2026
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IF 6.8
Yating Zhang,Jiayi Chen,Shaoying He,Qiuping Tan,Weihong Chi,Leqian Wang,Lexin Ling,Lingyang Fan,Hui Fan
Ethnopharmacological relevance Bupleurum chinense DC. ( Radix Bupleuri , Chaihu) has traditionally been applied to “soothe the liver and relieve depression.” Contemporary pharmacological evidence indicates that Radix Bupleuri (RB) and its active components exhibit anti-inflammatory, antitumor, and antidepressant effects. Nevertheless, the mechanisms underlying its antidepressant activity remain unclear. Aim of the study To evaluate the antidepressant-like effects of RB in mouse models and to determine whether modulation of peripheral inflammatory status is associated with changes in the brain monoamine neurotransmitter system. Materials and Methods A metabolic inflammation mouse model was established to investigate the regulatory effects of RB on hepatic lipopolysaccharide-binding protein (LBP) expression and the transcription of genes involved in the nuclear factor κB (NF-κB) signaling pathway. Subsequently, an inflammatory model was established in human hepatocellular carcinoma cells (HepG2) to examine the effects of saikosaponin and other herbal monomers on LBP expression at the transcriptional level. Finally, the chronic unpredictable mild stress (CUMS) mouse model was used to assess whether RB improves depressive-like behaviors by regulating hepatic LBP and modulating the NF-κB signaling pathway, thereby preserving the catalytic activity of monoamine-synthesizing enzymes, including tyrosine hydroxylase, tryptophan hydroxylase 2, DOPA decarboxylase, and dopamine β-hydroxylase. Results RB alleviated lipid metabolic disorders and hepatic inflammatory infiltration in the metabolic inflammation model, downregulated hepatic LBP expression, and suppressed NF-κB pathway activation at the transcriptional level. In vitro, saikosaponin A markedly reduced LBP mRNA expression compared with 15 other herbal monomers. Similarly, RB ameliorated depression-like behaviors in the CUMS model by downregulating hepatic LBP protein and mRNA expression, suppressing NF-κB pathway activation, and mitigating peripheral inflammatory signaling that interferes with the central nervous system. These effects subsequently enhanced monoamine biosynthesis, leading to elevated levels of 5-hydroxytryptamine, norepinephrine, and dopamine. Conclusion RB alleviates depression by regulating hepatic LBP through the liver–brain axis to restore brain monoamine balance, consistent with the traditional Chinese medicine concept of “soothing the liver and relieving depression.”
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PubMed
高影响因子
JOURNAL OF POWER SOURCES
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2026
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IF 8.4
Yiqian Wu,Lingping Pu,Yu Kuang,Jianhua Ding,Xiang Ke,Rengui Xiao,Lin Fu
Aluminum (Al) foil is a generally used cathode current collector in lithium-ion batteries (LIBs). During operation, insufficient interfacial compatibility between the current collector and the active material can lead to the delamination of the active material. Additionally, the surface of the Al foil is susceptible to corrosion by the electrolyte, which further compromises the structural integrity of the current collector. Addressing the challenges of existing modification techniques, which often rely on complex processes and struggle to simultaneously achieve interfacial modification and corrosion protection, this study employs a simple electrochemical polymerization strategy. It constructs a polyaniline (PANI) layer with a 3D array structure on the Al foil surface, integrating the dual functions of enhanced interfacial adhesion and electrolyte protection. The LFP battery assembled with the modified current collector (LFP-PANI/Al) has exhibited 6.2% increase in discharge-specific capacity at 1 C rate compared to the LFP battery assembled with bare Al foil current collector (LFP-Bare Al). Meanwhile, after 1000 cycles at 2 C rate, the discharge-specific capacity has reached 63.9 mAh g −1 , while the LFP-Bare Al group has achieved only 32.6 mAh g −1 . This work offers new insights for future modifications of current collectors to improve the long-term cycling stability of LIBs.
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Journal of Environmental Chemical Engineering
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2026
·Vol. 14
·期 5
·124645
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IF 7.5
Xingwang Xu,Jiayi Liu,Bin Lin,Tianyi Sui,Jinming Li,Bingrui Lv,Pengcheng Zhao,Hetian Hou,Cong Chen,Hualong Zhang,Yuhao Zhang,Jinhua Wei,Haoji Wang,Mingqiang Tang
Photocatalysis assisted chemical mechanical polishing is considered an effective method for achieving atomic-scale flatness on reaction-sintered silicon carbide (RS-SiC) surfaces. However, the recombination of photogenerated carriers severely limits its further development. Meanwhile, photoelectric and other multi-energy field catalysis assisted chemical mechanical polishing can solve the above problems, but it will significantly increase energy consumption and pollution, but it will significantly increase energy consumption and pollution. In this study, t-BaTiO 3 was regarded as catalyst, and a piezoelectric-photocatalysis assisted chemical mechanical cost-effective and efficient polishing technology was proposed. Polishing pressure and shear force induce a built-in electric field in t-BaTiO 3 , thereby inhibiting the recombination of photogenerated carriers. The experimental results showed that, compared with photocatalysis oxidation, pressure-induced piezoelectric-photocatalysis treatment increased the oxygen content of the RS-SiC surface by 11.77%, reduced the surface hardness by 10.45 GPa, and yielded a polished surface roughness as low as 0.18 nm. More importantly, compared with the other methods, this approach reduced both cost and energy consumption by 50%. These findings confirm that the proposed method is an efficient and environmentally friendly polishing technology with substantial potential to advance chemical mechanical polishing.
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CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
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2026
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IF 3.8
Jia Qiao,Rao Fu,Yue-e Li,Xin Wan,Qiang Guo,Ming-xuan Li,Yang-yang Zheng,Ying-ying Zhang,Yu-jia Xu,Zhao Fu,Chun-qin Mao,De Ji,Jing Mao,Tu-lin Lu
The quality of traditional Chinese medicines is strongly influenced by geographical origin; however, existing methods for origin traceability and quality evaluation still struggle to balance analytical efficiency, operational convenience, and information completeness. In this study, 120 samples of Salvia miltiorrhiza (SM) were collected from five representative production regions in China. Computer vision (CV) was used to extract appearance features, including color, texture, and contour characteristics, while high-performance liquid chromatography (HPLC) was employed to determine the contents of active components. By integrating machine learning with multivariate statistical analysis, origin classification models were developed using single-modality data as well as data-level, feature-level, and decision-level fusion strategies, followed by prediction of chemical component contents based on CV features. Results from 50 repeated stratified random splits showed that the Categorical Boosting (CatBoost) model under the decision-level fusion strategy achieved an accuracy of 99.17% ± 1.29% for origin identification, demonstrating strong classification performance and stability. Shapley Additive Explanations (SHAP) analysis under the feature-level fusion strategy indicated that appearance traits and chemical constituents made synergistic contributions to origin discrimination. The CatBoost model was further optimized using five multi-objective optimization algorithms, which improved the overall predictive performance for active component contents, with NSGA-II exhibiting a comparatively balanced overall advantage. The multimodal data fusion and multi-objective optimization framework developed in this study provides a new technical pathway for the origin traceability and quality evaluation of SM and offers a methodological reference for the intelligent analysis of multisource information in Chinese medicinal materials.
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DENTAL MATERIALS
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2026
·
IF 6.3
Tianjia Huang,Huan Chen,Shuwei Qiao,Boyu Sun,Shuyao Zheng,Haiya Liao,Zuosen Shi,Song Zhu
A multifunctional Myr@ZIF-8 nanoplatform was developed for dentin bonding. • Myr@ZIF-8 exhibited pH-responsive release of myricetin and Zn²⁺. • Myr@ZIF-8 enhanced antibiofilm activity against Streptococcus mutans . • Myr@ZIF-8 stabilized dentin collagen and suppressed MMP activity. • The modified adhesive significantly improved dentin bonding durability. Objectives This study aimed to develop a myricetin-loaded ZIF-8 (Myr@ZIF-8)-modified universal adhesive with antibacterial, collagen-stabilizing, and matrix metalloproteinase (MMP)-inhibitory properties to improve bonding durability. Methods Myr@ZIF-8 nanoparticles were synthesized and characterized. Myr loading efficiency, drug loading, and pH-responsive release were evaluated. Myr@ZIF-8 was incorporated into a universal adhesive at 2.5–10 wt%, and the optimal concentration was selected according to degree of conversion, dentin wettability, and antibiofilm activity. Dentin collagen stability, MMP-mediated gelatinolytic activity, microtensile bond strength (μTBS), interfacial nanoleakage, interfacial mechanical properties, and in vitro cytocompatibility were evaluated. Short-term systemic toxicity was preliminarily assessed by oral gavage of cured adhesive extracts. Molecular docking was performed to investigate potential interactions between myricetin and collagen, MMP-2, and MMP-9. Results Myr@ZIF-8 exhibited a Myr loading efficiency of 50.72%, drug loading of 50.36%, and pH-responsive release. The adhesive containing 5 wt% Myr@ZIF-8 showed the best overall performance, including enhanced antibiofilm activity, improved collagen stability, and reduced MMP-mediated gelatinolytic activity. Incorporation of 5 wt% Myr@ZIF-8 increased immediate μTBS from 22.79 MPa to 32.07 MPa and aged μTBS after 10,000 thermocycles from 13.91 MPa to 27.99 MPa. Molecular docking predicted potential interactions between myricetin and collagen, MMP-2, and MMP-9. The modified adhesive showed acceptable in vitro cytocompatibility, with no obvious short-term systemic toxicity after oral gavage of cured adhesive extracts. Significance These findings demonstrate that Myr@ZIF-8 functions as a multifunctional bioactive nanoplatform and represents a promising strategy for improving bonding durability. Download: Download high-res image (189KB) Download: Download full-size image Schematic diagram of the experimental process.
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Frontiers in Veterinary Science
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2026
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IF 3.1
Jiajia Wang,Xiaolei He,Lijiao Yang,Lanting Yang,Xiubo Li,Fei Xu
Bovine endometritis is a major reproductive disorder in cattle that reduces fertility, prolongs calving intervals, and decreases productivity in the livestock industry. However, limitations in current therapeutic approaches underscore the need for novel and more effective therapeutic formulations. This study aimed to develop an enrofloxacin suspension-based thermosensitive hydrogel intrauterine infusion (Enro-TSH). We utilized 16% Poloxamer 407 and 0.5% Poloxamer 188 as the gel matrix and Carbopol 941 as the suspending agent. We screened formulations with Carbopol 941 contents of 0.00%−0.14% by characterizing their rheological properties, sedimentation volume ratio, in vitro release profiles and microstructures, and identified 0.08% as the optimal Carbopol concentration. The optimally screened formulation Enro-TSH-Car8 showed viscosities (η) of 6.04 ± 0.59 Pa·s at 4°C, 7.22 ± 0.31 Pa·s at 25°C, and 785 ± 42.46 Pa·s at 38.5°C, with a gelation temperature of 35.60 ± 0.75°C and gelation time of 123 ± 8 s. We then conducted in vitro release studies using 0.9% sodium chloride solution as the medium, and obtained cumulative release rates of 48.73 ± 2.61% at 12 h and 94.1 ± 3.89% at 24 h. Specifically, the cumulative release profile from 1 to 24 h closely fitted a zero-order kinetic equation (R2 = 0.991). Drug release from 1 to 6 h adhered to the Ritger-Peppas model (R2 = 0.992, n > 0.89), indicating a matrix erosion mechanism, whereas release from 6 to 24 h complied with the Higuchi model (R2 = 0.999), suggesting a diffusion-driven mechanism. In addition, we characterized the freeze-dried formulation via scanning electron microscopy (SEM), and neither enrofloxacin nor Carbopol significantly affected the gel microstructure. Overall, this study successfully developed a thermosensitive intrauterine infusion loaded with suspended enrofloxacin particles for bovine endometritis. This novel integrated system unites thermo-responsive hydrogel and suspension formulation, adopting the lowest reported Poloxamer 407 content (16%) and an optimized Carbopol concentration to balance suspension stability and rheological properties. Meanwhile, the enrofloxacin-loaded formulation exhibits a mild pH value (7.0 ± 0.2), providing a promising strategy for the treatment of bovine endometritis.
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Advanced Science
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2026
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IF 14.1
Zhengdong Zhang,Pan Liu,Jie Lei,Shuchang Peng,Qiu Chen,Wei Guan,Yizhou Zhu,Gang Liu,Xiaobo Feng,Cao Yang,Lei Tan
The sterility and controllable biological functionalities of implantable medical devices determine their lifespan, safety, and therapeutic efficacy. Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, we have developed an electronic chip-mimetic sonothermal platform through constructing metal-semiconductor heterogeneous interface. Through magnetron sputtering on the surface of the sandblasted/acid-etched pretreated titanium (pTi), we find that semiconductor coatings (TiO 2 , Si, ZnO, and Te) endow pTi with different in situ sonothermal effects (ΔT > 18°C, 15 min) under ultrasound (US) irradiation, whereas conductor coatings do not. The sonothermal mechanism of pTi-semiconductor is associated with US-activated electron and phonon transport within the heterogeneous interface of implants, which is determined by the electrical and phonon characteristics of pTi-semiconductor, including their matching degree, thermal conductivity, defected structure, and type of semiconductor. Clinical titanium screws were introduced with defected structure in oxygen layer (TiO 2-x ) and bone-derived whitlockite, which shows great sonothermal/sonodynamic effects for efficient elimination of biofilm infection and improved osseointegration. In addition, the prepared NiTi-TiO 2-x guidewire enables rapid thrombolysis (30 min) in the deep vein thrombosis of beagles after 10 min of sonothermal/urokinase treatment. The electronic chip-mimetic sonothermal platform provides a promising and widespread clinical application prospect.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Bohan Zhang,Jinying Lin,Wenzheng Wu,Zhenglong Chen,Ruiyun You,Yudong Lu,Tao Zhang,Yong Fan
A hydrogel SERS platform requiring no pretreatment has been developed. • The LOD for DOX and MTO were as low as 3.4 × 10 −8 M and 3.6 × 10 −9 M. • Machine learning achieved a 100% identification for DOX and MTO plasma samples. Rapid quantitative detection and classification of trace drugs directly in complex biological fluids are crucial in modern analytical chemistry. This paper proposes a label-free, interference-resistant smart surface-enhanced Raman scattering (SERS) sensing strategy. A machine learning-assisted Au@Ag/C-CNF/PEGDA hydrogel SERS sensor is developed for monitoring and identifying anthracycline anticancer drugs in plasma. Addressing the susceptibility to contamination and oxidation inherent in conventional SERS sensors, this sensor leverages the pore-trapping effect and nanoparticle encapsulation properties of hydrogel. This approach not only eliminates macromolecular interference but also maintains a high signal output of 71.05% for the internal Au@Ag SERS probe after 50 days. Leveraging the electrostatic interactions of carboxylated cellulose (C-CNF), the sensor exhibits excellent signal reproducibility with detection limits as low as 3.4 × 10 −8 M for doxorubicin (DOX) and 3.6 × 10 −9 M for mitoxantrone (MTO). Furthermore, this study employed machine learning models for high-dimensional feature extraction of SERS data, achieving up to 100% classification accuracy for DOX and MTO in spiked plasma samples. This approach holds promise as a robust solution for clinical drug concentration monitoring and species identification, potentially advancing precision treatment strategies in clinical practice. Download: Download high-res image (183KB) Download: Download full-size image
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高影响因子
MATERIALS RESEARCH BULLETIN
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2026
·
IF 5.8
Huabo Li,Dong Bai,Lu Zhou
Eight post-synthesis acid treatments were systematically compared under identical polyol-derived Pt/C preparation conditions. • Citric acid treatment at pH 2 achieved 99% Pt loading efficiency and an ECSA of 106.2 m 2 gPt −1 . • The citric acid-treated catalyst delivered an ORR mass activity of 0.279 A mgPt −1 , exceeding that of commercial Pt/C. • After 30,000 potential cycles, the citric acid-treated catalyst showed a lower ECSA loss than commercial Pt/C (25.3% vs. 42.3%). Proton exchange membrane fuel cells (PEMFCs) are promising electrochemical energy-conversion devices, but their performance is limited by the sluggish kinetics of the oxygen reduction reaction (ORR). In this study, the effects of post-synthesis acid treatment on polyol-derived Pt/C catalysts supported on Vulcan XC-72 were systematically investigated. Eight chemically distinct acids, including citric, sulfuric, phosphoric, tartaric, oxalic, nitric, acetic, and hydrochloric acids, were compared under otherwise identical preparation conditions, followed by a separate citric-acid dosage series corresponding to final pH values of 2–5. The influences of acid chemistry and post-treatment pH on Pt retention, nanoparticle size and dispersion, Pt surface oxidation state, electrochemically active surface area (ECSA), ORR activity, and durability were evaluated. Thermogravimetric analysis showed that the citric-acid-treated catalyst exhibited a residual Pt fraction of 29.68 wt%, corresponding to approximately 99% of the nominal Pt loading. XRD and TEM analyses revealed Pt crystallite and particle sizes in the range of approximately 2.2–3.8 nm, with the citric-acid-treated catalyst showing relatively small and uniformly dispersed Pt nanoparticles. At pH 2, the citric-acid-treated catalyst achieved the highest ECSA of 106.2 m 2 gPt −1 and an ORR mass activity of 0.279 A mgPt −1 at 0.9 V vs. RHE, exceeding the values measured for commercial Johnson Matthey HiSPEC™ 3000 Pt/C (91.1 m 2 gPt −1 and 0.216 A mgPt −1 , respectively). XPS further showed that the citric-acid-treated catalyst retained a relatively high fraction of metallic Pt, consistent with its favorable electrochemical accessibility and surface state. After 30,000 potential cycles, the citric-acid-treated catalyst exhibited a lower ECSA loss than the commercial reference (25.3% vs. 42.3%) and less XRD-detectable crystallite coarsening. Single-cell measurements under matched cathode Pt loading also showed higher cell voltages for the citric-acid-treated catalyst over the investigated current-density range. These results indicate that post-synthesis citric acid treatment can improve Pt retention, nanoparticle dispersion, electrochemical accessibility, ORR activity, and structural durability through acid-dependent surface and Pt–carbon interfacial effects. The present protocol was demonstrated at a laboratory scale, yielding approximately 80 mg of catalyst per batch. Download: Download high-res image (152KB) Download: Download full-size image A comparative analysis was conducted on the oxygen reduction activity of Pt/C catalysts obtained under various chelating agents and their dosages. The optimal chelating agent and its corresponding amount were identified, and an in-depth investigation was carried out to understand the factors contributing to their superior performance.
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高影响因子
Journal of Water Process Engineering
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2026
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IF 6.6
Guangyu Duan,Xiaoya Li,Shuai Wang,Ru Zheng
The PNVP-GO composite was fabricated for efficient heavy metal removal. • The composite exhibited a high adsorption capacity of 86.96 mg·g −1 for Pb 2+ . • Topological analyses unveiled a synergistic dual-site specific adsorption mechanism. • Flexible PNVP chains overcome Pb 2+ lone pair hindrance via V-shaped cavity formation. A poly( N -vinylpyrrolidone)-graphene oxide (PNVP-GO) composite synthesized via optimized suspension polymerization demonstrated exceptional performance in removing Cu 2+ , Ni 2+ , and Pb 2+ . Adsorption of Cu 2+ and Ni 2+ followed the Langmuir isotherm, Pb 2+ recognition exhibited pronounced surface energetic heterogeneity accurately described by the three-parameter Sips and Toth models. Mechanistically, all uptake processes were rate-governed by spontaneous, endothermic chemisorption, consistent with the pseudo-second-order (PSO) kinetics, achieving maximum capacities of 73.96, 77.76, and 86.96 mg·g −1 for Cu 2+ , Ni 2+ , and Pb 2+ , respectively. X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR) confirmed chemisorption, while density functional theory (DFT) coupled with wavefunction topological analyses (ELF and IGMH) unveiled distinct dual-site specific adsorption mechanisms. Rigid GO carboxyl domains efficiently coordinate Cu 2+ and Ni 2+ but experience steric repulsion against the stereochemically active 6s 2 lone pair of Pb 2+ . Crucially, flexible PNVP chains overcome this barrier via conformational torsion (forming a V-shaped cavity) to accommodate the massive lone pair. A life cycle assessment (LCA) evaluated environmental sustainability and identified grid electricity for vacuum freeze-drying as the primary driver of Global Warming Potential (GWP, 75%). In comparison, ethanol washing was identified as the major contributor to Marine Eutrophication Potential (MEP, 29%). This study provides a universal theoretical paradigm for designing heavy metal adsorbents and highlights eco-design pathways to mitigate their life-cycle environmental footprints. Download: Download high-res image (288KB) Download: Download full-size image
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高影响因子
EUROPEAN POLYMER JOURNAL
·
2026
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IF 6.8
Yunhang Zhu,Yang Ke,Feiyan Lu,Hongna Jiang,Qingting Liu,Xudong Fu,Rong Zhang,Shengfei Hu,Gang Xiao,Feng Zhao,Xiao Li,Jun Yang
High-temperature proton exchange membranes (HT-PEMs) suffer from an unavoidable trade-off between proton conductivity and mechanical strength under wide-temperature and anhydrous environments. Herein, copolymerized DA-PBI/SPEEK composite membranes are fabricated via hydrogen-bond-driven interphase engineering. The sulfonic acid groups of SPEEK form intense acid-base pairs with imidazole and amino sites on DA-PBI, the synergistic effects of flexible chain segments and intermolecular hydrogen bonding significantly enhance polymer miscibility and construct a robust acid-base interaction network. Quantum chemical calculations and charge density difference (CDD) analysis confirm that the nitrogen active sites of DA-PBI anchor phosphoric acid via electronic rearrangement, which remarkably lowers the energy barrier for proton migration. The optimal membrane achieves a tensile strength of 130 MPa (3.25 times that of pristine SPEEK) and a peak power density of 0.536 W cm −2 (1.85 times that of pristine SPEEK) at 160 °C. This multi-scale strategy combining molecular chain tailoring, interfacial modulation, and electronic structure optimization resolves the conductivity-mechanical property dilemma of PBI-based membranes, offering a promising route to advanced anhydrous HT-PEMs.
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JOURNAL OF HAZARDOUS MATERIALS
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2026
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IF 10.6
Chang Liu,Yujing Huang,Yiyi Ma,Shuang Song,Tao Chen,Feng Jiang,Chenghan Wang,Feilong Dong,Tuqiao Zhang
During long-term operation, drinking water distribution pipelines develop complex inner-wall deposits composed of corrosion scale, sediments, and biofilm, which can serve as reservoirs and secondary sources of organic micropollutants and heavy metals. Conventional pipe cleaning technologies mainly rely on physical scouring to remove deposits, but offer limited capacity to control micropollutant release during cleaning. Here, a peroxymonosulfate/citric acid (PMS/CA) modified ice slurry was developed to integrate physical cleaning with in situ organic contaminant degradation and heavy metal removal. Results showed that CA complexed with iron species to maintain soluble Fe(II) in the reaction system and accelerate Fe(III)/Fe(II) redox cycling, thereby enabling continuous PMS activation and sustained reactive oxygen species generation. Under optimized conditions, the modified ice slurry achieved 90.88% degradation of carbamazepine within 10 min, accompanied by an overall reduction in predicted product toxicity. Meanwhile, CA enhanced the removal of Cr(VI) and Cd(II) from pipe scale matrices by promoting solubilization, which also lowered the risk of rerelease during subsequent stagnation. Validation under near realistic operating conditions further demonstrated the practical applicability of the modified ice slurry for pipeline cleaning. Life cycle assessment indicated that PMS/CA modified ice slurry imposed the lowest environmental impacts across most categories at an equivalent pollutant removal level among the compared oxidation and cleaning technologies. This study provides an effective and environmentally pipe cleaning strategy for coordinated deposit removal and micropollutant control in drinking water distribution systems.
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危险品化学品经营许可证（带存储）