INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2022
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IF 7.139
Lan Wang,Ning Gong,Zhou Zhou,Wenchao Peng,Yang Li,Fengbao Zhang,Xiaobin Fan
Developing highly efficient, durable and noble-metal-free electrocatalysts for hydrogen evolution reaction (HER) in a wide pH range is the key to achieve sustainable energy cycle. Modulating the electronic characteristics of catalysts is of great important to enhance their electrocatalytic performance. Herein, we successfully design a self-supported multi-element transition metal phosphide (V-CoP/Ni 2 P/NF) electrocatalyst by V-doping and interface engineering. According to DFT calculations, V dopants and the synergistic effect between CoP and Ni 2 P can bring optimal hydrogen/water adsorption free energies . Meanwhile, the 3D cross-linked network structure could expose abundant active sites and facilitate ions diffusion/electron transfer. As a result, the V-CoP/Ni 2 P/NF catalysts exhibit superior electrocatalytic activities with extremely low overpotentials of 20, 58 and 79 mV to deliver a current density of 10 mA cm −2 for HER in alkaline, neutral and acidic electrolytes, respectively. Moreover, they also display outstanding long-term stability. This electronic modulation strategy provides a promising pathway for energy-related catalysis processes.
研究领域:
材料科学
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电化学
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能源催化
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2023
·Vol. 24
·期 4
·3859
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IF 5.6
Jingyi Zhu,Xiangning Li,Wenling Gao,Jian Jing
Malignant melanoma, an increasingly common form of skin cancer, is a major threat to public health, especially when the disease progresses past skin lesions to the stage of advanced metastasis. Targeted drug development is an effective strategy for the treatment of malignant melanoma. In this work, a new antimelanoma tumor peptide, the lebestatin–annexin V (designated LbtA5) fusion protein, was developed and synthesized by recombinant DNA techniques. As a control, annexin V (designated ANV) was also synthesized by the same method. The fusion protein combines annexin V, which specifically recognizes and binds phosphatidylserine, with the disintegrin lebestatin (lbt), a polypeptide that specifically recognizes and binds integrin α1β1. LbtA5 was successfully prepared with good stability and high purity while retaining the dual biological activity of ANV and lbt. MTT assays demonstrated that both ANV and LbtA5 could reduce the viability of melanoma B16F10 cells, but the activity of the fusion protein LbtA5 was superior to that of ANV. The tumor volume growth was slowed in a mouse xenograft model treated with ANV and LbtA5, and the inhibitory effect of high concentrations of LbtA5 was significantly better than that of the same dose of ANV and was comparable to that of DTIC, a drug used clinically for melanoma treatment. The hematoxylin and eosin (H&E) staining test showed that ANV and LbtA5 had antitumor effects, but LbtA5 showed a stronger ability to induce melanoma necrosis in mice. Immunohistochemical experiments further showed that ANV and LbtA5 may inhibit tumor growth by inhibiting angiogenesis in tumor tissue. Fluorescence labeling experiments showed that the fusion of ANV with lbt enhanced the targeting of LbtA5 to mouse melanoma tumor tissue, and the amount of target protein in tumor tissue was significantly increased. In conclusion, effective coupling of the integrin α1β1-specific recognition molecule lbt confers stronger biological antimelanoma effects of ANV, which may be achieved by the dual effects of effective inhibition of B16F10 melanoma cell viability and inhibition of tumor tissue angiogenesis. The present study describes a new potential strategy for the application of the promising recombinant fusion protein LbtA5 in the treatment of various cancers, including malignant melanoma.Keywords:malignant melanoma;annexin V;lebestatin;antitumor
研究领域:
肿瘤学
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药理学
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分子生物学
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癌症研究
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DOI
PubMed
高影响因子
Environment & Health
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2024
·
IF 0
Juan Liu,Yangyang Liu,Yunyun Zhang,Xuejun Ruan,Hanyun Cheng,Qiuyue Ge,Liwu Zhang
Bioaerosols pose a great threat to human life and health, and developing highly efficient and accurate identification and analysis methodologies for bioaerosols provides prerequisite knowledge to evaluate their toxicity on human health. In this paper, a rapid and economical method is proposed for the detection of bioaerosols based on surface-enhanced Raman scattering (SERS). The SERS substrate was prepared using an anodic aluminum oxide (AAO) template with an inverted conical (V-shaped) nanopore array structure that was subsequently deposited with Ag nanoparticles (AgNPs) through magnetron sputtering. This tailored nanostructure essentially enables the differentiated and efficient detection of Escherichia coli and Staphylococcus epidermidis health risks within 10 min, along with corresponding detection limits of 103 cells/mL and 104 cells/mL, respectively. Notably, by comparing the Raman spectrum of the two bacteria obtained from the plain plane deposited with the same AgNPs, the V-shaped nanopore array structure provides a more robust enhancement effect in the Raman signal relative to the ordinary plane. More importantly, the applicability of developed AgNPs@V-shaped AAO SERS substrate was validated using ambient bioaerosols, thus emphasizing the great potential of the application of SERS-based technique for a cost-effective, rapid label-free and culture-free bioaerosol analysis without experiencing conventional time-consuming and laborious incubation processes.
研究领域:
生物医学工程
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分析化学
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纳米技术
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环境健康
✓ 已验证
DOI
CHEMICAL ENGINEERING JOURNAL
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2014
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IF 4.058
Ting Zhang,Yaobin Ding,Heqing Tang
An efficient singlet oxygen generation system was first developed by using Bi(V)/Bi(III) composites for degrading organic pollutants . The composites were prepared by hydrolyzing NaBiO 3 in HCl solutions. As monitored by various techniques, it was found that the morphology and composition of the composites were able to be tuned by changing the molar ratio of HCl to NaBiO 3 in the preparation process, which was optimized at 2.0. Due to the efficient generation of singlet oxygen, the use of the composite (0.75 g L −1 ) resulted in almost complete degradation of bisphenol A (0.2 mmol L −1 ) in 20 min, with a pseudo-first-order kinetic constant of 0.14 min −1 . The dominant reactive species in the degradation system were confirmed to be singlet oxygen, which was generated from the release of the lattice oxygen in the composite. The good performances of the concerned singlet oxygen generation system are general for degrading different organic pollutants.
研究领域:
环境科学
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化学
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产品关联
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
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2023
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IF 9.8
Linfeng Peng,Hui Li,Wangjun Lin,Tangfu Xiao,Jianqiao Wang,Jinfeng Tang,Nana Wang
Antimony (Sb) pollution in water has attracted extensive attention due to the biotoxicity of Sb. Secondary iron minerals readily sorb heavy metal(loid)s and critically affect their cycling in terrestrial environments. However, compared with synthetic pure iron mineral phases, little is known about the Sb sorption behavior and mechanism on natural secondary iron minerals (nSIMs) composed of various mineral phases. In this study, sorption experiments were conducted to investigate the Sb(V) sorption properties of nSIMs from an acid mine drainage zone and corresponding single-component synthetic secondary mineral phases and to compare their sorption behaviors and mechanisms. Spectroscopic analyses indicated that the nSIMs structurally resembled a hybrid of schwertmannite , jarosite and goethite . Sb(V) sorption on nSIMs, schwertmannite, goethite and jarosite was controlled by chemisorption , with maximum Sb(V) sorption capacities of 217.39, 233.65, 32.17 and 35.61 mg/g, respectively. nSIMs demonstrated an excellent Sb(V) sorption capacity equivalent to or greater than that of the single-component phases. XRD, FTIR and Raman analyses indicated that Sb(V) was immobilized on nSIMs mainly through ion exchange with structural SO 4 2− and complexation interactions with surface Fe O and Fe OH; then, an Fe O Sb surface phase formed during the dissolution and further transformation of schwertmannite and jarosite into goethite. SEM revealed that nSIMs had an advantage in surface microstructure over the single components. These results suggested that despite the similarities in Sb(V) binding mechanism between nSIMs and schwertmannite, nSIMs might be more reactive for Sb(V) sorption since the nSIM components could mutually influence each other and facilitate Sb(V) sorption. This research suggests that nSIMs have potential for Sb(V) removal and helps elucidate the environmental behavior of Sb(V) associated with nSIMs.
研究领域:
环境科学
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地球化学
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产品关联
DOI
高影响因子
DALTON TRANSACTIONS
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2023
·Vol. 52
·期 22
·7447-7456
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IF 4
Qian Chen,Jianfeng Huang,Ting Xiao,Liyun Cao,Dinghan Liu,Xiaoyi Li,Mengfan Niu,Guoting Xu,Koji Kajiyoshi,Liangliang Feng
Exploring low-cost and highly active photocatalysts with noble metal-free cocatalysts is of great significance for photocatalytic hydrogen evolution under simulated sunlight irradiation. In this work, a novel V-doped Ni2P nanoparticle loaded g-C3N4 nanosheet is reported as a highly efficient photocatalyst for H2 evolution under visible light irradiation. The results demonstrate that the optimized 7.8 wt% V-Ni2P/g-C3N4 photocatalyst exhibits a high hydrogen evolution rate of 271.5 μmol g−1 h−1, which is comparable to that of the 1 wt% Pt/g-C3N4 photocatalyst (279 μmol g−1 h−1), and shows favorable hydrogen evolution stability for five successive runs within 20 h. The remarkable photocatalytic hydrogen evolution performance of V-Ni2P/g-C3N4 is mainly due to the enhanced visible light absorption ability, the facilitated separation of photo-generated electron–hole pairs, the prolonged lifetime of photo-generated carriers and the fast transmission ability of electrons.
研究领域:
材料科学
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能源化学
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产品关联
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2018
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IF 3.141
Lijin Huang,Jiayu Cai,Man He,Beibei Chen,Bin Hu
Magnetic metal–organic framework composites (MFCs) were prepared in water at room temperature through a simple, low-cost and green strategy only by employing organic salts as anionic linker sources. Amino-functionalized MFCs (MFC-N) with different amino group contents were successfully prepared by varying the ratio of disodium of 2-aminoterephthalic (NH2-Na2BDC)/terephthalic acid (Na2BDC). The prepared nanoscale MFC-N-X (X represents the percentage of NH2-Na2BDC, i.e., X = 0, 50, and 100) showed high surface area, large pore volume, excellent magnetic response, and good water and thermal stability. Among these prepared MFC-N-X, MFC-N-100 exhibited the highest adsorption capacity of 358 mg g–1 for methylene blue (MB) and 71 mg g–1 for As(V) due to its porous structure and abundant amino groups. The prepared MFC-N-100 was successfully applied to remove MB and As(V) from different water samples (tap water, lake water, and domestic sewage) with a high removal efficiency and a rapid separation of the sorbent from solution, demonstrating the great application potential of the prepared MFC-N-100 as a fascinating adsorbent for removal of dyes or metal ions from different water samples.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Husnain Raza,Siqian Li,Qian Zhou,Jiayi He,Ka Wing Cheng,Shuhong Dai,Mingfu Wang
V-type starch-polyphenol complexes, known for their improved physicochemical properties compared to native starch, are challenging to form efficiently. In this study, the effects of tannic acid (TA) interaction with native rice starch (NS) on digestion and physicochemical properties were investigated using non-thermal ultrasound treatment (UT). Results showed the highest complexing index for NSTA-UT3 (∼ 0.882) compared to NSTA-PM (∼0.618). NSTA-UT complexes reflected the V6I-type complex having six anhydrous glucose per unit per turn with peaks at 2θ = 7°, 13°, and 20°. The maxima of the absorption for iodine binding were suppressed by the formation of V-type complexes depending on the concentration of TA in the complex. Furthermore, rheology and particle size distributions were also affected by TA introduction under ultrasound, as revealed by SEM. XRD, FT-IR, and TGA analyses confirmed V-type complex formation for NSTA-UT samples, with improved thermal stability and increased short-range ordered structure. Ultrasound-induced addition of TA also decreased the hydrolysis rate and increased resistant starch (RS) concentration. Overall, ultrasound processing promoted the formation of V-type NSTA complexes, suggesting that tannic acid could be utilized for the production of anti-digestion starchy foods in the future.
研究领域:
食品科学
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生物化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2024
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IF 5.8
Chenxi Wu,Huajun Lai,Feng Wang,Dianhui Wang,Weijiang Gan,Yulai She,Zhongmin Wang
V-based alloy membranes have huge potential for hydrogen separation and purification due to their higher hydrogen permeability , but suffer from hydrogen embrittlement . To address this matter, Pd and Fe have been chosen as alloying additions in V-based membranes to inhibit hydrogen embrittlement and maintain high hydrogen permeation performance based on the lattice-matching strategy. The phase structure, composition, microstructure and hydrogen permeation properties of V-Pd-Fe ternary alloy are investigated systematically, and the V-Fe and V-Pd binary alloys are presented for comparison. The results show that the prepared V-Pd-Fe ternary can match almost perfectly with pure V in lattice constants . Attributing to the lattice-matching strategy, the V-Pd-Fe ternary alloy exhibits more excellent hydrogen permeable properties than that of V-Fe and V-Pd binary alloys . The reduction of hydrogen embrittlement is ascribed to the lower hydrogen solubility that induced by the lattice distortion and electronegativity of Fe and Pd. Meanwhile, the manipulated lattice constant that parallel to pure V maintains high hydrogen permeation performance. Additionally, the designed ternary V 87.8 Pd 8 Fe 4.2 alloy exhibits exceptional long-term hydrogen permeation stability at 573 and 623 K, and hydrogen flux gradually decreases at 673 and 723 K is observed due to the interdiffusion between Pd film and V 87.8 Pd 8 Fe 4.2 substrate and defects in the Pd coating. This study offers new scenario and method for optimized hydrogen permeable properties and restrains hydrogen embrittlement in the alloy membrane.
研究领域:
材料科学
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氢能与储能
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金属膜分离技术
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固态氢传输
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合金设计
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物理冶金学
✓ 已验证
DOI
高影响因子
INORGANIC CHEMISTRY
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2024
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IF 4.3
Juan Cui,Jun Li,Zhengyu Zhang,Tongtong Xu,Zegeng Chen,Zeyang Zhang,Qingxin Meng,Zhongxiang Zhou
Electromagnetic wave absorption performance is strictly dependent on attenuation and impedance matching, which are directly influenced by the ratio of MXene/MAX in the multilayer structured MXene/MAX composites. However, there is still a challenge to achieve collaborative optimization of dielectric loss and impedance matching by precisely regulating the proportional relationship of MXene/MAX. Herein, V-based MXene/MAX heterostructure composites with different V2C/V2AlC ratios were successfully synthesized by rationally controlling the temperature and time of the hydrothermal reaction. Experimental results indicated that V2C-100 °C-1 harvested the balance between reduced impedance matching and enhanced dielectric losses, which was attributed to the mildly enhanced conduction loss and polarization loss. The first principles indicated that abundant electrons migrate from the V atoms of the MXene to the C atoms of the MAX phase. The charge redistributed and accumulated at the interface, exciting the increase in the dielectric loss of V2C-100 °C-1. As a result, the V2C-100 °C-1 heterostructure composite had an excellent electromagnetic absorption effect with a minimum reflection loss of −50.06 dB and a wide effective absorption bandwidth of 4.0 GHz (12.72–16.72 GHz). This work provides a valuable experience for the development of efficient MXene-based microwave absorbing materials.
研究领域:
材料科学
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电磁学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2018
·
IF 2.441
Guisheng Zhou,Yulong Zhang,Yang Li,Mengyue Wang,Xiaobo Li
Mogroside V, a natural compound isolated from the fruits of Siraitia grosvenorii (Swingle), is a promising candidate for anti-diabetic activity. The present study aims to develop a simple and practical strategy for comparing the in vivo metabolite profiling of mogroside V in healthy and type 2 diabetic (T2D) model rats. In this paper, a highly sensitive and rapid ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) with MetaboLynx™ software combined with mass defect filtering (MDF) method was established and successfully applied to detect and identify the metabolites in plasma, urine, bile and feces samples of healthy and model rats administrated with mogroside V. The distribution of metabolites in plasma, bile, urine and feces of healthy and model rats had obvious differences. A total of 23 metabolites were observed in healthy rats while 26 metabolites were detected in model rats. The results indicated that dehydrogenation , deoxidation , oxidation and isomerization were the major metabolic transformations of mogroside V. Additionally, it was noticed that the peak areas of metabolites in T2D rat plasma samples were much larger than those of metabolites in healthy rat plasma sample, whereas in T2D rat urine samples they were remarkably smaller compared with healthy rat urine sample. These high blood concentrations of metabolites might be beneficial for the treatment of T2D. The results of this study are valuable and important in understanding the metabolic process and therapeutic mechanism of mogroside V.
研究领域:
药理学
·
代谢组学
·
糖尿病研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Bioscience
·
2024
·
IF 4.8
Jinzhe Li,QiuWan Jiang,Ruyi Zhang,Shiyi Guo,Zhanmei Jiang,Juncai Hou
Due to uneven distribution amino acid residues of α-lactalbumin (αLA) at oil-water interface, some measurement should be adopted to improve its interfacial behavior and emulsion stability. Therefore, this study focused on the mechanism of synergy of ultrasound and high pressure homogenization on the emulsion stability and interfacial behaviors of α-lactalbumin with mogroside V (MGV). Four treatments were adopted: ultrasound (US), high pressure homogenization (HPH) and combined treatment (US-HPH and HPH-US). Primarily, emulsion stability of αLA/MGV was analyzed. US-HPH or HPH-US exhibited better emulsion stability than US or HPH. Especially, HPH-US-αLA/MGV emulsion was not stratified at the given time (45 d), which was the most stable emulsion. Moreover, the micromorphology of emulsion showed that MGV and UH/HPH treatment suppressed the aggregation of αLA emulsion droplet. In addition, interfacial adsorption mass and viscoelasticity of physical treated αLA was improved with MGV in the order of HPH-US > US-HPH > US > HPH, specifically, frequency shift (ΔF) and dissipation shift (ΔD) of HPH-US-αLA/MGV was 42.2% and 32.5% higher than that without MGV. This finding may provide a potential approach for obtaining natural and high-efficient protein-based emulsifier in food industry.
研究领域:
食品科学
·
界面化学
·
蛋白质工程
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）