Biomaterials Science
·
2019
·Vol. 8
·期 2
·720-738
·
IF 5.251
Siming Yu,Guanning Huang,Riming Yuan,Tianfeng Chen
In the present work, an iridium (Ir) complex loaded theranostic nanoplatform was designed for high-efficiency triple-negative breast cancer (TNBC) therapy. For this purpose, the Ir complex was firstly loaded on a photothermal agent of gold nanostars (GNS) by simply mixing followed by functionalization using a urokinase-type plasminogen activator receptor (uPAR) targeted polyetherimide-AE105 peptide conjugate (P-AE105) with the formation of GNS@Ir@P-AE105. It was demonstrated that the resultant GNS@Ir@P-AE105 was a multifunctional nanoplatform with advantages of (1) NIR laser controlled release of the Ir complex; (2) precise delivery of the Ir complex to TNBC cells; (3) excellent photothermal (PT)/photoacoustic (PA)/X-ray computed tomography (CT) tri-modal imaging ability; and (4) a synergistic photothermal-chemotherapeutic effect. An in-depth investigation of the mechanism revealed that binding forces of the Ir complex–GNS and P-AE105–GNS were significantly diminished upon NIR laser irradiation, which conferred an NIR laser-responsive Ir complex release property to the nanoplatform. Moreover, the nanoplatform exerted high efficiency anti-TNBC effects via a ROS-induced p53 apoptotic pathway. Specifically, combinational photothermal-chemotherapeutic treatments stimulated intracellular ROS generation, which significantly up-regulated apoptotic-relative p53 gene expression either by causing severe DNA damage or inducing an arrest effect on the sub-G1 phase of the cell cycle. Taken together, our work provides a novel theranostic nanoplatform for efficient and simultaneous diagnosis and therapy of TNBC.
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MICROCHIMICA ACTA
·
2017
·Vol. 184
·期 9
·3469-3475
·
IF 4.58
Tang Yiwei,Li Min,Gao Xue,Liu Xiuying,Gao Jinwen,Ma Tao,Li Jianrong
The paper describes the preparation of a fluorescent probe based on the use of up-conversion particles (UCPs) of the type NaYF 4 : Er, Yb and shelled with a molecularly imprinted polymer (MIP) that is specific for the antibiotic enrofloxacin. The upconverted green luminescence emitted by the UCPs upon photoexcitation at 980 nm was used to locally generate a thin MIP shell around the UCPs via photopolymerization. Enrofloxacin is used as the template, and ethylene glycol dimethacrylate (EGDMA) as the cross-linking agent. It is found that enrofloxacin is well captured by the MIP and then quenches the fluorescence of the UCPs. Fluorescence decreases linearly in the 63 ng·L −1 to 60 μg·L −1 enrofloxacin concentration range, with a 8 ng·L −1 limit of detection. The method was applied to the determination of enrofloxacin in spiked fish samples. Recoveries ranged from 83.7 to 87.7%, with relative standard deviations between 2.0 and 5.5% (for n = 3).
Schematic of an NIR-responsive up-conversion nanoparticle probe of the NaYF 4 :Er,Yb type and coated with a MIP for fluorometric determination of enrofloxacin. The upconverted luminescence emitted by the UCPs was used to locally generate a thin MIP shell around the UCPs via photopolymerization.
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JOURNAL OF MOLECULAR STRUCTURE
·
2024
·
IF 4
Qifeng Chen,Yu Yao,Shuo Zheng,Qianhong Shen,Libei Jiang,Qinhua Fang,Hui Yang
A novel Yb 3+ /Er 3+ co-doped BiOBr photocatalyst with 3D flowerlike hierarchical architectures were successfully fabricated through self-assembled process without any templates under hydrothermal conditions, and the structure and properties of the photocatalysts were characterized. The results indicate that Yb 3+ ions and Er 3+ ions are successfully doped into the lattice of BiOBr, and the as-obtained photocatalyst can respond the NIR light and emit red and green light due to the up-conversion effect of the rare-earth ions. Meanwhile, with co-doped Yb 3+ /Er 3+ ions content increasing, oxygen vacancy concentration in the photocatalyst rises. The oxygen vacancy will form the intermediate energy band, which can decrease the photon energy required for electronical transition, and thus help to utilize the luminous energy generated by up-conversion luminescence. Moreover, the appropriate introduction of defects (oxygen vacancy defect and impurity atom) can further promote the transfer and separation efficiency of photo-generated carriers. Hence, Yb 3+ /Er 3+ co-doped BiOBr photocatalyst exhibits enhanced photocatalytic properties under broad spectrum (UV/vis/NIR) excitation, which is about 4 times as high as that of pure BiOBr.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Kunpeng Lin,Shaochen Wang,Shuling Yu,Wen Si,Miaojie Yang,Ningning Xu,Yu Liu,Yan Zheng,Shuang Zhao,Jiahua Shi,Jintao Yuan
Porphyrins are popular photosensitizers for photodynamic therapy of diseases. However, the poor water solution and short absorption wavelengths of porphyrins limit their clinical application. In this work, a novel worm-like porphyrin covalent organic framework (Por-COF) with excellent dispersibility and near-infrared absorption was prepared via a facile method. First, a pH-responsive macromolecule was prepared using Schiff base bonds between porphyrin and terephthalaldehyde, and the spatial arrangement of macromolecules was controlled to prepare Por-COF. Second, the hypoxia-responsive drug tirapazamine (TPZ) and tumor-targeted hyaluronic acid (HA) were loaded to Por-COF through the electrostatic effect to prepare a multifunction nanomedicine (Por-COF@TPZ/HA) that could simultaneously produce abundant reactive oxygen species and high temperature via808 nm laser irradiation. TPZ was cascaded for the synergistic therapy of cancers. In vitro cytotoxicity showed that the inhibition rate of cell activity in the Por-COF@TPZ/HA + Laser group was 1.2 times higher than that in the Por-COF/HA + Laser group. In vivo experiments also demonstrated that the aggravated tumor hypoxia caused by photodynamic therapy could activate TPZ to achieve high-efficiency chemotherapy. Combined photodynamic–photothermal therapy and chemotherapy had an outstanding synergistic effect. This work provides a promising method for Por-COF preparation and a feasible strategy for the synergistic therapy of cancers.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2020
·
IF 4.845
Shundong Cai,Jianhua Yan,Hongjie Xiong,Qing Wu,Hang Xing,Yanfei Liu,Song Liu,Zhenbao Liu
Molybdenum disulfide (MoS 2 ), one representative 2D nanomaterial, has recently emerged as a unique platform in the biomedical field. However, its application in drug delivery systems should be further exploited. Here, we report a novel tumor cell targeting and lysosomal acidic environment/NIR laser dual responsive drug delivery system for synergetic chemo-photothermal treatment of cancer cells. The MoS 2 nanosheets were loaded with chemotherapy drug doxorubicin (DOX) and coated with polydopamine (PDA) layer. Then, thiolated aptamer AS1411 and polyethylene glycol (PEG) were modified onto MoS 2 nanosheets through Michael addition reaction to construct [email protected] 2 nanosheets. The aptamer modification endowed the nanoplatform with targeting ability to breast cancer MCF-7 cells. MoS 2 and PDA converted 808 nm NIR laser into heat and played the role of photothermal therapy (PTT). Tumor lysosomal acidic environment and NIR laser irradiation accelerated the release of DOX from the nanosheets. The nanocarrier Apt-PEG-PDA-MoS 2 showed good biocompatibility, and [email protected] 2 showed synergetic chemo-photothermal therapy effects with significantly enhanced anti-tumor efficacy, suggesting that this MoS 2 -based drug delivery platform is promising for targeted and synergetic treatment of cancer.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Ning Ding,Bo Zhang,Imran Mahmood Khan,Mingwei Qin,Shuo Qi,Xiaoze Dong,Zhouping Wang,Junsong Yang
The prevalence of pathogenic bacterial infections with high morbidity and mortality poses a widespread challenge to the healthcare system. Therefore, it is imperative to develop nanoformulations capable of adaptively releasing antimicrobial factors and demonstrating multimodal synergistic antimicrobial activity. Herein, an NIR-activated multifunctional synergistic antimicrobial nanospray MXene/ZIF-90@ICG was prepared by incorporating ZIF-90@ICG nanoparticles onto MXene-NH2 nanosheets. MXene/ZIF-90@ICG can on-demand release the antimicrobial factors MXenes, ICG, and Zn2+ in response to variations in pH and ATP levels within the bacterial infection microenvironment. Under NIR radiation, the combination of MXenes, Zn2+, and ICG generated a significant amount of ROS and elevated heat, thereby enhancing the antimicrobial efficacy of PDT and PTT. Meanwhile, NIR excitation could accelerate the further release of ICG and Zn2+, realizing the multimodal synergistic antibacterial effect of PDT/PTT/Zn2+. Notably, introducing MXenes improved the dispersion of the synthesized antimicrobial nanoparticles in aqueous solution, rendering MXene/ZIF-90@ICG a candidate for application as a nanospray. Importantly, MXene/ZIF-90@ICG demonstrated antimicrobial activity and accelerated wound healing in the constructed in vivo subcutaneous Staphylococcus aureus infection model with NIR activation, maintaining a favorable biosafety level. Therefore, MXene/ZIF-90@ICG holds promise as an innovative nanospray for adaptive multimodal synergistic and efficient antibacterial applications with NIR activation.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Luogen Lai,Wanqing Zou,Yan Zhang,Yuanbiao Tu,Simeng Li,Tongxuan Xin,Tianyue Zhou,Shan Xu,Pengwu Zheng,Qingshan Pan,Wufu Zhu
Bacterial infections and antibiotic resistance have become a global healthcare crisis. There is an urgent need to develop visualized therapeutic platforms that allow accurate imaging of the bacterial infections, successful eradication of bacteria and real-time monitoring of treatment progress. In this work, we report a novel NIR imaging and synergistic antibacterial nano-system ( [email protected] ) for resistance bacterial infection therapy. The multifunctional nano-system is fabricated by a MIL-101 core, which is covalently connected with Vancomycin and modified with targeted antimicrobial peptides LL-37 on the surface. The ability of monitoring the progress of infection treatment and effective promoting wound healing of bacterial infection are proved by in vivo MRSA -infected mice models. Under the environment of endogenous H 2 O 2 overexpression and slightly acid bacterial infection, the excellent Fenton-like reaction activity of [email protected] could effectively catalyze the decomposition of H 2 O 2 to produce hydroxyl radicals (•OH), which trigger highly efficient chemo-dynamic therapy (CDT) and tissue protection effect. By combining CDT with antibacterial peptides and antibiotics therapy, special targeting and synergistic killing of MRSA are successfully achieved in in vitro and in vivo antibacterial assays with excellent biocompatibility. Due to this, this study proposes a novel, high-efficient, multifunctional imaging and therapy system, which will open a new avenue for the design of synergistic antibacterial and diagnostic platforms in the future.
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Materials Today
·
2025
·
IF 22
Haiping Luo,Shenglan Zhou,Wenjie Deng,Jiahao Liu,Jiaqing Peng,Bo Li,Zhihua Xiong,Wei Wang,Xinyu Ye
Fe 3+ is a promising near-infrared (NIR) activator ion due to its tunable emission and non-toxicity, which has attracted growing interest. However, developing high-performance broadband NIR-emitting phosphors based on Fe 3+ remains a significant challenge. In this work, we present Fe 3+ -activated A 2 LuSbO 6 (A = Ba/Sr/Ca) double perovskite phosphors, which exhibit unusually long-wavelength NIR emission (>850 nm). By adopting a cation substitution strategy at the A-site, we designed the gradual replacement of large-radius ions with small-radius ions, achieving controllable tuning of emission from 847 nm to 937 nm. This substitution process simultaneously reduces structural symmetry and induces octahedral distortion, which breaks the spin-forbidden transition of Fe 3+ and enhances luminescence performance. However, the continuous emission redshift leads to a large Stokes shift, which suppresses Fe 3+ luminescence. The combined effect of these two factors results in optimal luminescence efficiency in Sr 2 LuSbO 6 :1.0 %Fe 3+ (SLSO) sample, with internal/external quantum efficiencies (IQE/EQE) of 94.8 %/54.5 %. To further enhance luminescence performance, we introduced the rare-earth Yb 3+ , establishing an efficient Fe 3+ →Yb 3+ energy transfer (ET) channel that reduces non-radiative transition losses. Compared with the Yb 3+ -free sample, the SLSO:1.0 %Fe 3+ , 3.0 %Yb 3+ sample exhibits a broadened FWHM from 115 nm to 180 nm, enhanced IQE and EQE of 98.1 % and 56.4 %, respectively, and 13 % improved thermal stability. Finally, a pc-LED device based on the SLSO:1.0 %Fe 3+ , 3.0 %Yb 3+ phosphor demonstrates potential for applications in NIR spectroscopy analysis, night vision, biomedical imaging, and other fields. This work lays a foundation for further research on strategies to regulation the optical properties of Fe 3+ -activated NIR phosphors.
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APPLIED SURFACE SCIENCE
·
2020
·
IF 6.182
Ning Li,Xueyun Gao,Haikuan Fan,Yangqin Gao,Lei Ge
Effective and suitable utilization of solar energy was achieved using a full-spectrum-response photocatalyst AgBr/Cs x WO 3 , applied in the photocatalytic and photochromic field. Benefitting from near-infrared (NIR) absorption ability of Cs x WO 3 , AgBr/Cs x WO 3 exhibits enhanced visible-near-infrared (Vis-NIR) driven photocatalytic activity. Based on X-ray photoelectron spectroscopy (XPS), photoluminescence spectra (PL), and the photoelectrochemical analysis, AgBr and Cs x WO 3 formed a Z-scheme system at the interface to efficiently separate and transfer photo-induced electrons at a fast rate. The quenching experiment and the electron spin resonance (ESR) tests indicated that the photocatalytic reaction is activated by the production of superoxide radicals. Furthermore, the photochromic analysis to different light exhibits the AgBr/Cs x WO 3 heterostructure is stable under visible light with negligible photodeposition of AgBr, and has excellent double photochromic activity with visible-shielding effect of AgBr to Ag 0 and infrared-blocking effect of Cs x WO 3 under ultraviolet light. This research provides new insights into the manufacture of energy-efficient and environmentally friendly materials that provide excellent performance in both thermal insulation and decontamination.
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JOURNAL OF LUMINESCENCE
·
2026
·
IF 3.8
Viswadevarayalu Annavaram,Weicheng Xiang,Zihang Chai,Kangwei Zhu,Zaifa Pan
Enhanced quantum-cutting (QC) materials are highly desirable for promising applications such as solar cells. In this work, a series of Ce 3+ , Gd 3+ , and Yb 3+ tri-doped phosphors using Y 2 SiO 5 as the host were synthesized via a solid-state reaction. X-ray diffraction confirms that the dopants do not alter the monoclinic phase of Y 2 SiO 5 . Photoluminescence spectroscopy reveals that, the optimized tri-doped phosphor exhibits intense near-infrared (NIR) emission centered at 976 nm under UV excitation. Mechanism investigation reveals that Gd 3+ preferentially occupies the 7-coordinate Y2 site (associated with the Ce 3+ 392-nm emission), displacing Ce 3+ ions toward the 6-coordinate Y1 site (associated with the 425-nm emission). The Y1-site Ce 3+ emission at ∼425 nm (≈23,500 cm −1 ) is energetically closer to twice the Yb 3+ absorption energy (≈20,000 cm −1 ) than the Y2-site emission at ∼392 nm (≈25,500 cm −1 ), making the Y1 site more favorable for cooperative energy transfer to Yb 3+ pairs. This site-selective occupation effect significantly enhances the quantum-cutting efficiency. Furthermore, the synthesized tri-doped phosphor demonstrates superior performance in NIR phosphor-converted LEDs (pc-LEDs), achieving an electrical-to-optical conversion efficiency 1.55 times that of the co-doped counterpart. The output power of the tri-doped NIR LED is enhanced to 206.4% of that of the co-doped device. For solar cell applications, the short-circuit current density (J SC ) of the tri-doped device reaches 2.47 mA/cm 2 , with a power conversion efficiency (η) of 10.58%. The tri-doped phosphor solar cell exhibits an extra 0.1% enhancement in conversion efficiency compared to the co-doped counterpart. These results highlight the potential of Y 2 SiO 5 :Ce 3+ ,Gd 3+ ,Yb 3+ as an efficient spectral converter for boosting the energy yield of silicon photovoltaics.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Xiaodong Lin,Bergoi Ibarlucea,Tao Peng,Ren Shen,Peiyue Li,Pan Zhang
Susceptibility point-of-care testing (POCT) and bacterial inactivation are crucial for food safety and clinical diagnosis since bacteria pose a severe hazard to public health and healthcare. To enable photothermal determination and hyperthermal inactivation of bacteria, vancomycin-modified near-infrared (NIR)-responsive copper selenide nanoparticles (Cu 2−X [email protected] NPs) with excellent photothermal conversion are synthesized here. Cu 2−X [email protected] NPs can be trapped on the surface of Gram-positive bacteria such as Staphylococcus aureus ( S. aureus ), forming a Cu 2−X [email protected] NPs/ S. aureus complex. Suspension (Cu 2−X [email protected] NPs) and sediment (Cu 2−X [email protected] NPs/ S. aureus ) can convert the NIR laser energy into a thermal signal that can be detected by the thermal camera at concentrations as low as 6.0 CUF mL −1 . Meanwhile, S. aureus can be effectively inactivated by localized temperature rises during temperature-based signal detection. The antibacterial efficiency can reach as high as 99.53%. The proposed strategy not only provides a sensitive POCT strategy for bacterial determination but also implements efficient inactivation of bacteria simultaneously.
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ACS Sensors
·
2022
·
IF 9.618
Zhidong Qiu,Chaobang Zhang,Liangliang Zhang,Shulong Wang,Shengqiang Hu,Shulin Zhao
The interaction between light and biological tissues in the second near-infrared (NIR-II) window is weak, which can effectively reduce the scattering and absorption of incoming light by biological tissues and enhance the resolution and sensing ability of in vivo photoacoustic (PA) imaging. In particular, tissues that carry blood and water produce the lowest PA background in the wavelength range of 1050 to 1150 nm. However, the development of the NIR-II PA probe for the above window faces great challenges. To tackle this challenge, the reduction–reoxidation of an organic dye was used to develop a PA imaging probe (Hydro-1048) as the first NIR-II PA probe of a hydroxy radical (·OH) for molecular imaging in deep tissue. The ·OH oxidized the C–N single bond in Hydro-1048 to double bonds, which formed Et-1065. This conversion extended the conjugate system of the molecule and shifted the absorption peak from 520 to 1065 nm, which resulted in a strong PA signal after irradiation with a 1065 nm laser. At a detection limit of 0.6 nM, a good linear relationship within the range of 5–1000 nM was obtained for the PA signal intensity versus the concentration of ·OH. The developed NIR-II PA probe can be used for the noninvasive high-resolution imaging of ·OH in deep tissue, and the PA imaging of ·OH can also be used to visually monitor in situ pathological processes related to hepatitis.
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